Somatic cell reprogramming for Parkinson's disease treatment
Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
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Expression of a sonic hedgehog signal transducer, hedgehog-interacting protein, by human basal cell carcinoma [PDF]
, 2002 Michiko Tojo +3 more
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Mechanisms of enhancer‐driven oncogene activation
International Journal of Cancer, EarlyView.Abstract An aggressive subtype of acute myeloid leukemia (AML) is caused by enhancer hijacking resulting in MECOM overexpression. Several chromosomal rearrangements can lead to this: the most common (inv(3)/t(3;3)) results in a hijacked GATA2 enhancer, and there are several atypical MECOM rearrangements involving enhancers from other hematopoietic ...
Joyce Vriend +2 more
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Effect of Naringenin on Potassium Bromate–Induced Hepatotoxicity In Vivo: A Dose‐Dependent Study
Journal of Applied Toxicology, EarlyView.ABSTRACT Potassium bromate (PB) is a well‐known additive in the food industry and a byproduct of water treatment. Its long‐term exposure to any form of life exerts mild to severe toxic insults in a dose‐dependent fashion and can even trigger carcinogenesis.
Iftekhar Hassan +6 more
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Protein kinase A and hedgehog signaling in drosophila limb development
, 1995 Jin Jiang, Gary Struhl
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Expression and localization of Indian hedgehog (Ihh) and parathyroid hormone related protein (PTHrP) in the human growth plate during pubertal development [PDF]
, 2002 Jenny M. Kindblom +4 more
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A Retinoid Antagonist Attenuates Bone Growth Inhibition Caused by Growth Plate Injury in Mice
Journal of Orthopaedic Research, EarlyView.ABSTRACT Growth plate injury, which may trigger growth plate fusion or arrest, is a common occurrence in pediatric orthopaedics that can lead to angulation of the limb and limb length discrepancy. Growth plate injuries are currently treated palliatively, with surgical intervention when severe limb length discrepancy or angulation is found during follow‐
Masatake Matsuoka +8 more
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Developmental Pathways in Musculoskeletal Neoplasia: Involvement of the Indian Hedgehog-Parathyroid Hormone-Related Protein Pathway [PDF]
, 2003 Tri Dung Tiet, Benjamin A. Alman
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Advances in prognostic biomarkers for biliary atresia: Current insights and future directions
Journal of Pediatric Gastroenterology and Nutrition, EarlyView.Abstract Biliary atresia (BA) is a progressive, fibrosing cholangiopathy of infancy characterized by inflammatory obstruction of the bile ducts, ultimately leading to end‐stage liver disease if untreated. Early diagnosis and timely surgical intervention via hepatoportoenterostomy (HPE) are critical for improving outcomes; however, prognostication ...
Ahmad Anouti +6 more
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