Results 161 to 170 of about 100,157 (319)
Small Science, EarlyView.Both native and engineered extracellular vesicles (EVs) are served as promising therapeutic agents for treating acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). To circumvent the limitations of native EVs, various engineering strategies are adopted.
Zhengyan Gu +12 more
wiley +1 more source
Molecular mechanisms of Eda‐mediated adaptation to freshwater in threespine stickleback
Molecular Ecology, EarlyView., 2023 Abstract A main goal of evolutionary biology is to understand the genetic basis of adaptive evolution. Although the genes that underlie some adaptive phenotypes are now known, the molecular pathways and regulatory mechanisms mediating the phenotypic effects of those genes often remain a black box.
Carlos E. Rodríguez‐Ramírez +5 more
wiley +1 more source
Small Methods, EarlyView.Harnessing synthetic key receptor modulators, this study presents a breakthrough in Wnt/β‐catenin regulation. The FZD agonist RRP‐pbFn bypasses LRP5/6 to drive organoid expansion and tissue regeneration, while the LRP antagonist RRP‐Dkk1c eradicates tumors. These tools enable precise pathway control, advancing regenerative and cancer therapies.
Quanhui Dai +9 more
wiley +1 more source
Small Structures, EarlyView.Micro/nanorobots have been developed and deployed, revealing their state‐of‐the‐art applications in pollution detection and remediation. Innovative research progress includes collective behaviors, advanced propulsion mechanisms, and functionalization strategies that enhance their efficiency in diverse and complex aquatic environments, pointing toward ...
Yingyi Gan, Bin Wang, Yuan Lu
wiley +1 more source
Hedgehog Signaling Regulation of Homeodomain Protein Islet Duodenum Homeobox-1 Expression in Pancreatic -Cells [PDF]
, 2001 Melissa K. Thomas
openalex +1 more source
FASEB BioAdvances, EarlyView.NPC1L1 Inhibits Osteogenesis via the C/EBPα/Cyp27a1/27‐OHC Axis in Osteoporosis Mechanism: ○NPC1L1 expression decreases during osteogenic differentiation. ○NPC1L1 knockdown enhances osteoblast differentiation, proliferation, and migration. ○NPC1L1 promotes cholesterol metabolism (independent of transport function), elevating Cyp27a1‐dependent 27 ...
Bohao Li +9 more
wiley +1 more source
Expression and localization of Indian hedgehog (Ihh) and parathyroid hormone related protein (PTHrP) in the human growth plate during pubertal development [PDF]
, 2002 Jenny M. Kindblom +4 more
openalex +1 more source
THE COSMOPOLITICS OF CATS AND WILDLIFE ON CAPE TOWN'S URBAN EDGE
International Journal of Urban and Regional Research, EarlyView.Abstract Free‐ranging cats are widely tolerated in cities, and animal welfare organizations increasingly allow for ‘trap, neuter and release’ (TNR) of unowned cats. We show, using the example of a university campus adjacent to a national park in a large metropole, that this has implications for cosmopolitics over biodiversity on the urban edge.
Nicoli Nattrass +3 more
wiley +1 more source
Expression of a sonic hedgehog signal transducer, hedgehog-interacting protein, by human basal cell carcinoma [PDF]
, 2002 Michiko Tojo +3 more
openalex +1 more source