Results 191 to 200 of about 100,157 (319)

The Zebrafish-Secreted Matrix Protein You/Scube2 Is Implicated in Long-Range Regulation of Hedgehog Signaling [PDF]

, 2005
Atsushi Kawakami, Yasuhiro Nojima, Atsushi Toyoda, Mikako Takahoko, Miki Satoh, Hideomi Tanaka, Hironori Wada, Ichiro Masai, Harumi Terasaki, Yoshiyuki Sakaki, Hiroyuki Takeda, Hitoshi Okamoto   +11 more
openalex   +1 more source

G protein‐coupled receptor‐mediated autophagy in health and disease

British Journal of Pharmacology, EarlyView.
G protein‐coupled receptors (GPCRs) constitute the largest and most diverse superfamily of mammalian transmembrane proteins. These receptors are involved in a wide range of physiological functions and are targets for more than a third of available drugs in the market. Autophagy is a cellular process involved in degrading damaged proteins and organelles
Devrim Öz‐Arslan, Zeynep Aslıhan Durer, Beki Kan   +2 more
wiley   +1 more source

An unusual choanoflagellate protein released by Hedgehog autocatalytic processing [PDF]

, 2005
Elizabeth A. Snell, Nina M. Brooke, William R. Taylor, Didier Casañe, Hervé Philippe, Peter W. H. Holland   +5 more
openalex   +1 more source

Identification of new small molecules for selective inhibition of SERCA 1 in patient‐derived metastatic papillary thyroid cancer

British Journal of Pharmacology, Volume 182, Issue 11, Page 2392-2408, June 2025.
Abstract Background and Purpose Papillary thyroid cancer (PTC) is a general thyroid cancer subtype; however, PTC is associated with metastasis or recurrence via anti‐cancer drug resistance, rendering it practically incurable. Therefore, effective and reliable clinical approaches are urgently required.
Seok‐Mo Kim, Keunwan Park, Hyeok Jun Yun, Jung Min Kim, Kyung Hwa Choi, Ki Cheong Park   +5 more
wiley   +1 more source

Introduction: Preface to the Hedgehog family of proteins review volume

, 2000
Philip W. Ingham, Marysia Placzek
openalex   +2 more sources

The Cell Surface Membrane Proteins Cdo and Boc Are Components and Targets of the Hedgehog Signaling Pathway and Feedback Network in Mice [PDF]

, 2006
Toyoaki Tenzen, Benjamin L. Allen, Francesca Cole, Jong-Sun Kang, Robert S. Krauss, Andrew P. McMahon   +5 more
openalex   +1 more source

System level network data and models attack cancer drug resistance

British Journal of Pharmacology, EarlyView.
Drug resistance is responsible for >90% of cancer related deaths. Cancer drug resistance is a system level network phenomenon covering the entire cell. Small‐scale interactomes and signalling network models of drug resistance guide directed drug development.
Márk Kerestély, Dávid Keresztes, Levente Szarka, Borbála M. Kovács, Klára Schulc, Dániel V. Veres, Peter Csermely   +6 more
wiley   +1 more source

Mefloquine Suppresses Metastasis in Renal Cell Carcinoma Through Targeting SPC25

Cancer Science, Volume 116, Issue 5, Page 1239-1254, May 2025.
We addressed the clinical issue of renal cell carcinoma metastasis by identifying SPC25 protein as a research target through bioinformatics techniques and validation with clinical samples. We comprehensively validated the function of SPC25 protein and determined its impact on renal cancer.
Yongbo Wang, He Wang, Yipeng Xu, Jiawei Ling, Chuhong Zong, Yan Zhang, Xiaoxuan Guo, Guanan Zhao, Yuan Zhou, Jiahui Zhao, Pengrong Lou, Xigao Liu, Tengfei Xu, Qi Ma   +13 more
wiley   +1 more source

Anti-pancreatic cancer activity of Z-ajoene from garlic: An inhibitor of the Hedgehog/Gli/FoxM1 axis

Journal of Functional Foods, 2019
Overexpression of glioma-associated oncogene (Gli), a transcription factor at the final step of Hedgehog (Hh) pathway, is involved in pancreatic cancer development.
Hwa Jin Lee, Ji Hye Jeong, Jae-Ha Ryu
doaj  

Assessing the palatability of different meats consumed in a biodiversity hotspot to inform alternative protein interventions

Conservation Biology, EarlyView.
Abstract Alternative protein interventions are common in conservation. They aim to reduce the hunting or consumption of wildlife by promoting substitutes. However, selecting suitable meat substitutes is challenging because many factors drive wild meat consumption. Palatability, one such factor, drives consumer food preference and is potentially crucial
Charles A. Emogor, Isa B. Ebri, Benedict A. Atsu, Dominic S. Ogu, Omini B. Iferi, Andrew Balmford   +5 more
wiley   +1 more source