Results 201 to 210 of about 100,157 (319)

The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila [PDF]

, 2007
Cristina Molnar, Helena Holguín, Federico Mayor, Ana Ruiz‐Gómez, José F. de Celis   +4 more
openalex   +1 more source

Conditional Overexpression of Net1 Enhances the Trans‐Differentiation of Lgr5+ Progenitors into Hair Cells in the Neonatal Mouse Cochlea

Cell Proliferation, Volume 58, Issue 4, April 2025.
This work investigated the in vivo role of Net1 in cochlear hair cell (HC) regeneration. Conditional overexpression of Net1 in Lgr5+ progenitors of neonatal mouse cochlea enhance HC regeneration by inducing direct trans‐differentiation of Lgr5+ progenitors into HCs probably via activation of Atoh1, Gfi1, and Pou4f3 transcription factors.
Yanqin Lin, Qiuyue Zhang, Wei Tong, Yintao Wang, Leilei Wu, Hairong Xiao, Xujun Tang, Mingchen Dai, Zixuan Ye, Renjie Chai, Shasha Zhang   +10 more
wiley   +1 more source

Protein Kinase A, not Epac, Suppresses Hedgehog Activity and Regulates Glucocorticoid Sensitivity in Acute Lymphoblastic Leukemia Cells [PDF]

, 2007
Zhenyu Ji, Fang Mei, Betty H. Johnson, E. Brad Thompson, Xiaodong Cheng   +4 more
openalex   +1 more source

Implication of GPRASP2 in the Proliferation and Hair Cell‐Forming of Cochlear Supporting Cells

Cell Proliferation, EarlyView.
Schematic diagram of GPRASP2‐mediated SCs proliferation and HCs formation. GPRASP2 deficiency results in increased lysosomal degradation of SMO. GPRASP2‐mediated SMO/GLI1 signalling promotes SC proliferation, which contributes to HC formation. GPRASP2‐mediated SMO/β‐catenin signalling is implicated in HCs fate specification and differentiation ...
Jing Cai, Kun Huang, Wenrui Li, Tianming Wang, Shen Yue, Zhibin Chen, Guangqian Xing, Qinjun Wei, Jun Yao, Xin Cao   +9 more
wiley   +1 more source

Signalling pathways in a nutshell: from pathogenesis to therapeutical implications in prostate cancer. [PDF]

Ann Med
Goncharov AP, Dicusari Elissaiou C, Ben Aharon Farzalla E, Akhvlediani G, Vashakidze N, Kharaishvili G.   +5 more
europepmc   +1 more source

Evolution of hedgehog and hedgehog-related genes, their origin from Hog proteins in ancestral eukaryotes and discovery of a novel Hint motif [PDF]

, 2008
Thomas R. Bürglin
openalex   +1 more source

Rapid and Effective Neuronal Conversion of Human Glioblastoma In Vitro and In Vivo Using Potent Small Molecules

Cell Proliferation, EarlyView.
A potent combination of small molecules YFSS (Y27632, Forskolin, SB431542, SP600125) that were screened through a neuronal‐specific promoter–reporter system TUBB3::mCherry effectively induces neuronal‐GBM conversion in vitro and in vivo, unveiling molecular mechanisms that offer a theoretical basis and a potential therapeutic strategy for treating GBM.
Ya'nan Hu, Jinming Liu, Jian Tu, Min Yang, Qisheng He, Fei Li, Xiaojing Xu, Zhongqing Ji, Jianwei Xu, Wentao Zhong, Mengwen Yan, Ying Yang, Huanxiang Zhang   +12 more
wiley   +1 more source

Gene proteins, growth factors/their receptors in the wall of chronic calculous cholecystitis-affected gallbladder children. [PDF]

BMC Pediatr
Derbeneva D, Pilmane M, Petersons A.
europepmc   +1 more source

Engineering Intervertebral Disc Regeneration: Biomaterials, Cell Sources and Animal Models

Cell Proliferation, EarlyView.
This review highlights the current tissue engineering approaches utilising biomaterials, animal models and cell sources for intervertebral disc regeneration and discusses future opportunities. ABSTRACT Intervertebral disc (IVD) degeneration is an age‐related problem triggering chronic spinal issues, such as low back pain and IVD herniation.
Sidong Yang, Farhad Soheilmoghaddam, Peter Pivonka, Joan Li, Samuel Rudd, Trifanny Yeo, Ji Tu, Yibo Zhu, Justin J. Cooper‐White   +8 more
wiley   +1 more source

Evaluation of Benzo[cd]indol-2(1H)-ones as Downstream Hedgehog Pathway Inhibitors. [PDF]

ChemistryOpen
Tsakoumagkos IA, Pasquer QTL, Guillod CL, Rossion C, Bagka M, Torche S, Sakata-Kato T, Chen JK, Hoogendoorn S.   +8 more
europepmc   +1 more source