PLoS ONE, 2014 Overexpression of Hedgehog family proteins contributes to the aetiology of many cancers. To be highly active, Hedgehog proteins must be palmitoylated at their N-terminus by the MBOAT family multispanning membrane enzyme Hedgehog acyltransferase (Hhat ...
Antonios D Konitsiotis +8 more
doaj +1 more source
Simultaneous measurement of smoothened entry into and exit from the primary cilium. [PDF]
PLoS ONE, 2014 Ciliary accumulation of signaling proteins must result from a rate of ciliary entry that exceeds ciliary exit, but approaches for distinguishing ciliary entry vs. exit are lacking.
Jynho Kim +5 more
doaj +1 more source
Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning [PDF]
, 2007 Sonic hedgehog (Shh) acts as a morphogen to mediate the specification of distinct cell identities in the ventral neural tube through a Gli-mediated (Gli1-3) transcriptional network.
Davidson, Eric H. +9 more
core +2 more sources
Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling [PDF]
Development, 2002 Hedgehog (Hh) signaling plays a major role in multiple aspects of embryonic development, which involves both short- and long-range signaling from localized Hh sources. One unusual aspect of Hh signaling is the autoproteolytic processing of Hh followed by lipid modification.
Takatoshi, Kawakami +5 more
openaire +2 more sources
Canonical Sonic Hedgehog Signaling in Early Lung Development
Journal of Developmental Biology, 2017 The canonical hedgehog (HH) signaling pathway is of major importance during embryonic development. HH is a key regulatory morphogen of numerous cellular processes, namely, cell growth and survival, differentiation, migration, and tissue polarity. Overall,
Hugo Fernandes-Silva +2 more
doaj +1 more source
Crystal Structure of a Hedgehog Autoprocessing Domain: Homology between Hedgehog and Self-Splicing Proteins [PDF]
Cell, 1997 The approximately 25 kDa carboxy-terminal domain of Drosophila Hedgehog protein (Hh-C) possesses an autoprocessing activity that results in an intramolecular cleavage of full-length Hedgehog protein and covalent attachment of a cholesterol moiety to the newly generated amino-terminal fragment.
Hall, Traci M.Tanaka +5 more
openaire +2 more sources
Loss of Pin1 Suppresses Hedgehog-Driven Medulloblastoma Tumorigenesis
Neoplasia: An International Journal for Oncology Research, 2017 Medulloblastoma is the most common malignant brain tumor in children. Therapeutic approaches to medulloblastoma (combination of surgery, radiotherapy, and chemotherapy) have led to significant improvements, but these are achieved at a high cost to ...
Tao Xu +14 more
doaj +1 more source
Atrioventricular canal defect and genetic syndromes: the unifying role of sonic hedgehog [PDF]
, 2019 The atrioventricular canal defect (AVCD) is a congenital heart defect (CHD) frequently associated with extracardiac anomalies (75%). Previous observations from a personal series of patients with AVCD and "polydactyly syndromes" showed that the distinct ...
Baban, A +9 more
core +1 more source
A Hedgehog-Induced BTB Protein Modulates Hedgehog Signaling by Degrading Ci/Gli Transcription Factor [PDF]
Developmental Cell, 2006 The Ci/Gli family of transcription factors mediates Hedgehog (Hh) signaling in many key developmental processes. Here we identify a Hh-induced MATH and BTB domain containing protein (HIB) as a negative regulator of the Hh pathway. Overexpressing HIB down regulates Ci and blocks Hh signaling, whereas inactivating HIB results in Ci accumulation and ...
Zhang, Qing +5 more
openaire +2 more sources
A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened. [PDF]
PLoS Genetics, 2011 Many signaling proteins including G protein-coupled receptors localize to primary cilia, regulating cellular processes including differentiation, proliferation, organogenesis, and tumorigenesis.
Seongjin Seo +6 more
doaj +1 more source