Results 41 to 50 of about 100,157 (319)

Stability of the B=2 hedgehog in the Skyrme model [PDF]

Nucl.Phys. A602 (1996) 347-374, 1995
We study the unstable modes of the baryon number two hedgehog of the Skyrme model on a three dimensional spatial lattice. An expansion of the Skyrme Lagrangian around the hedgehog configuration provides the equations of motion for the fluctuation fields solvable numerically via a relaxation method. We find the negative energy modes and, by evolving the
arxiv   +1 more source

Targeting GLI factors to inhibit the Hedgehog pathway [PDF]

, 2015
Hedgehog (Hh) signaling has emerged in recent years as an attractive target for anticancer therapy because its aberrant activation is implicated in several cancers. Major progress has been made in the development of SMOOTHENED (SMO) antagonists, although
Alfonsi, Romina, Botta, Bruno, DI MARCOTULLIO, Lucia, Infante, Paola, Mori, Mattia   +4 more
core   +2 more sources

Mechanism of exosomal miR-155 derived from bone marrow mesenchymal stem cells on stemness maintenance and drug resistance in myeloma cells

Journal of Orthopaedic Surgery and Research, 2021
Objective This study was to explore the effect of exosomal miR-155 derived from bone marrow mesenchymal stem cells (BMSCs) on stemness maintenance and drug resistance in MPC-11 multiple myeloma cells.
Xinyu Gao, Jin Zhou, Jinghua Wang, Xiushuai Dong, Yuying Chang, Yinglan Jin   +5 more
doaj   +1 more source

Could an endoneurial endothelial crosstalk between Wnt/β-catenin and Sonic Hedgehog pathways underlie the early disruption of the infra-orbital blood-nerve barrier following chronic constriction injury? [PDF]

, 2017
BackgroundBlood–nerve barrier disruption is pivotal in the development of neuroinflammation, peripheral sensitization, and neuropathic pain after peripheral nerve injury.
Boucher, Yves, Couraud, Pierre-Olivier, Mauborgne, Annie, Moreau, Nathan, Pohl, Michel, Romero, Ignacio A, Villanueva, Luis, Weksler, Babette B   +7 more
core   +3 more sources

Intein Inhibitors as Novel Antimicrobials: Protein Splicing in Human Pathogens, Screening Methods, and Off-Target Considerations

Frontiers in Molecular Biosciences, 2021
Protein splicing is a post-translational process by which an intervening polypeptide, or intein, catalyzes its own removal from the flanking polypeptides, or exteins, concomitant with extein ligation. Although inteins are highly abundant in the microbial
Diana A. Wall, Seanan P. Tarrant, Chunyu Wang, Chunyu Wang, Kenneth V. Mills, Christopher W. Lennon   +5 more
doaj   +1 more source

On Ramsey numbers of hedgehogs [PDF]

Combinator. Probab. Comp. 29 (2020) 101-112, 2019
The hedgehog $H_t$ is a 3-uniform hypergraph on vertices $1,\dots,t+\binom{t}{2}$ such that, for any pair $(i,j)$ with $1\le it$ such that $\{i,j,k\}$ is an edge. Conlon, Fox, and R\"odl proved that the two-color Ramsey number of the hedgehog grows polynomially in the number of its vertices, while the four ...
arxiv   +1 more source

Cholesterol accessibility at the ciliary membrane controls hedgehog signaling

eLife, 2019
Previously we proposed that transmission of the hedgehog signal across the plasma membrane by Smoothened is triggered by its interaction with cholesterol (Luchetti et al., 2016).
Maia Kinnebrew, Ellen J Iverson, Bhaven B Patel, Ganesh V Pusapati, Jennifer H Kong, Kristen A Johnson, Giovanni Luchetti, Kaitlyn M Eckert, Jeffrey G McDonald, Douglas F Covey, Christian Siebold, Arun Radhakrishnan, Rajat Rohatgi   +12 more
doaj   +1 more source

Cholesterol Chip for the Study of Cholesterol–Protein Interactions Using SPR

Biosensors, 2022
Cholesterol, an important lipid in animal membranes, binds to hydrophobic pockets within many soluble proteins, transport proteins and membrane bound proteins.
Peng He, Shannon Faris, Reddy Sudheer Sagabala, Payel Datta, Zihan Xu, Brian Callahan, Chunyu Wang, Benoit Boivin, Fuming Zhang, Robert J. Linhardt   +9 more
doaj   +1 more source

Response of nucleons to external probes in hedgehog models: I. Electromagnetic polarizabilities [PDF]

Phys.Rev.D47:299-312,1993, 1992
Electromagnetic polarizabilities of the nucleon are analyzed in a hedgehog model with quark and meson degrees of freedom.
arxiv   +1 more source

Changes in synaptic transmission and protein expression in the brains of adult offspring after prenatal inhibition of the kynurenine pathway [PDF]

, 2013
During early brain development, N-methyl-d-aspartate (NMDA) receptors are involved in cell migration, neuritogenesis, axon guidance and synapse formation, but the mechanisms which regulate NMDA receptor density and function remain unclear. The kynurenine
Ahn, Al-Hayani, Alberati-Giani, Alexander, Alexander, Alvarez, Angot, Baez, Banerjee, Beal, Breton, Broadstock, Brown, Brown, C.M. Forrest, Cai, Charytoniuk, Chess, Chess, Chess, Chiarugi, Clark, Colonnese, Copeland, Corbo, Couillard-Despres, Cozzi, Cuppini, D. Jerusalinsky, Dave, Dellovade, Dikranian, Dobbing, Dobelis, Drian, du Bois, Dykens, E. Kornisiuk, English, Erhardt, Ernst, Fagiolini, Fatemi, Fazio, Forrest, Forsythe, Friocourt, Gleeson, Gobaille, Goncalves, Guidetti, Guillemin, Guillemin, Gurdon, Harris, Harvey, Heng, Higgins, Higgins, Hilmas, Hiramatsu, Hoffman, Holtze, Hor, Hornig, Huang, Hynes, Ikonomidou, Iwasato, Jin, K. McNair, Kappeler, Kemp, Kerjan, L.G. Darlington, Larson, Leung, M. Pisar, M. Snitcofsky, Martel, Meyer, Miller, Mok, Munn, Myers, N. Gonzalez, Nacher, Nathan, Neale, Neher, Nilsson, Niswender, O.S. Khalil, Okuda, Otis, Ozaki, O’Kane, Palma, Parish, Pena, Perkins, Pfaffl, Pocivavsek, Potter, Prajerova, Rajan, Ramakers, Ramoa, Rodgers, Rosenmund, Röver, Saito, Saviane, Schwarcz, Schwarcz, Shin, Simon, Sims, Spassky, Stone, Stone, Stone, Stone, Stone, Stringer, T.W. Stone, Taleb, Tang, Traiffort, Traiffort, Traiffort, Traynelis, Udin, Ultanir, Vaillant, Vincent, Waldeck, Walker, Wang, Wang, Wierońska, Wu, Xiong, Zucker, Zuckerman   +144 more
core   +2 more sources