Response of nucleons to external probes in hedgehog models: II. General formalism [PDF]
Phys.Rev. D47 (1993) 313-324, 1992 Linear response theory for SU(2) hedgehog soliton models is developed.
arxiv +1 more source
Maml1 acts cooperatively with Gli proteins to regulate Sonic hedgheog signaling pathway [PDF]
, 2017 Sonic hedgehog (Shh) signaling is essential for proliferation of cerebellar granule cell progenitors (GCPs) and its misregulation is linked to various disorders, including cerebellar cancer medulloblastoma.
BELLAVIA, Diana +13 more
core +1 more source
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Hedgehog Signaling Modulates Glial Proteostasis and Lifespan
Cell Reports, 2020 Summary: The conserved Hedgehog signaling pathway has well-established roles in development. However, its function during adulthood remains largely unknown.
Andrew Rallis +6 more
doaj
RETRACTED: TMEM107 inhibits EMT and invasion of NSCLC through regulating the Hedgehog pathway
Thoracic Cancer, 2021 Background Transmembrane protein 107 (TMEM107) is a key regulator of the cilium composition and Hedgehog signaling. Lower TMEM107 gene copies are correlated with poor prognosis in non‐small cell lung carcinoma (NSCLC). However, TMEM107 protein expression,
Huihui Xu +5 more
doaj +1 more source
Rare coding SNP in DZIP1 gene associated with late-onset sporadic Parkinson's disease [PDF]
, 2011 We present the first application of the hypothesis-rich mathematical theory to genome-wide association data. The Hamza et al. late-onset sporadic Parkinson's disease genome-wide association study dataset was analyzed.
A Lerner +47 more
core +3 more sources
Advanced Biology, EarlyView.The manuscript examines preclinical murine and human models to study polycystic ovary syndrome (PCOS), delving into the cellular and molecular mechanisms underlying altered ovarian follicular dynamics. It explores the cellular interactions involved in normal and PCOS ovaries and outlines the current and novel strategies in the search for preclinical ...
Arturo Bevilacqua +5 more
wiley +1 more source
Overexpression of hedgehog signaling is associated with epidermal tumor formation in vitamin D receptor-null mice. [PDF]
, 2011 The vitamin D receptor (VDR) ligand, 1,25 dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), reduces proliferation and enhances differentiation, and thus has been investigated for a role in preventing or treating cancer.
Bikle, Daniel D +4 more
core +6 more sources
Hedgehogs in Wilson loops and phase transition in SU(2) Yang-Mills theory [PDF]
Nucl.Phys.B748:524-539,2006, 2005 We suggest that the gauge-invariant hedgehoglike structures in the Wilson loops are physically interesting degrees of freedom in the Yang--Mills theory. The trajectories of these ``hedgehog loops'' are closed curves corresponding to center-valued (untraced) Wilson loops and are characterized by the center charge and winding number.
arxiv +1 more source
Primary cilia disassembly down-regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes [PDF]
, 2014 SummaryObjectiveHedgehog signalling is mediated by the primary cilium and promotes cartilage degeneration in osteoarthritis. Primary cilia are influenced by pathological stimuli and cilia length and prevalence are increased in osteoarthritic cartilage ...
Chapple, JP, Knight, MM, Thompson, CL
core +2 more sources