Results 71 to 80 of about 93,686 (252)

Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold [PDF]

, 2018
Aberrant activation of the Hedgehog (Hh) pathway is responsible for the onset and progression of several malignancies. Small molecules able to block the pathway at the upstream receptor Smoothened (Smo) or the downstream effector Gli1 have thus emerged ...
Bruno Botta, Cinzia Ingallina, Elisa De Paolis, Flavia Bernardi, Francesca Ghirga, Isabella Romeo, Lucia Di Marcotullio, Mattia Mori, Miriam Caimano, Paola Infante, Romina Alfonsi, Sara Toscano, Simone Berardozzi   +12 more
core   +2 more sources

Hedgehog signaling promotes sorafenib resistance in hepatocellular carcinoma patient-derived organoids

Journal of Experimental & Clinical Cancer Research, 2020
Background The mechanism underlying sorafenib resistance in hepatocellular carcinoma (HCC) remains unclear. Accumulating evidence suggests that tumor-initiating cells (TICs) are a pivotal driving force. Both CD44 and Hedgehog signaling play crucial roles
Siqi Wang, Yang Wang, Xiaodong Xun, Changkun Zhang, Xiao Xiang, Qian Cheng, Shihua Hu, Zhao Li, Jiye Zhu   +8 more
doaj   +1 more source

Role of the Drosophila non-visual ß-arrestin kurtz in hedgehog signalling. [PDF]

PLoS Genetics, 2011
The non-visual ß-arrestins are cytosolic proteins highly conserved across species that participate in a variety of signalling events, including plasma membrane receptor degradation, recycling, and signalling, and that can also act as scaffolding for ...
Cristina Molnar, Ana Ruiz-Gómez, Mercedes Martín, Susana Rojo-Berciano, Federico Mayor, Jose F de Celis   +5 more
doaj   +1 more source

Sonic hedgehog is basolaterally sorted from the TGN and transcytosed to the apical domain involving Dispatched-1 at Rab11-ARE

Frontiers in Cell and Developmental Biology, 2022
Hedgehog proteins (Hhs) secretion from apical and/or basolateral domains occurs in different epithelial cells impacting development and tissue homeostasis.
Lisette Sandoval, Mariana Labarca, Mariana Labarca, Claudio Retamal, Claudio Retamal, Paula Sánchez, Juan Larraín, Alfonso González, Alfonso González, Alfonso González   +9 more
doaj   +1 more source

Clinical Implication of Targeting of Cancer Stem Cells [PDF]

, 2012
The existence of cancer stem cells (CSCs) is receiving increasing interest particularly due to its potential ability to enter clinical routine. Rapid advances in the CSC field have provided evidence for the development of more reliable anticancer ...
Al-Hajj M, Bao S, Bardsley MR, Barlogie B, Bentzen SM, Bertout JA, Blazek ER, Bruns CJ, Brunsvig PF, C.J. Bruns, Cao X, Chen MS, Clayton S, Collins AT, Cortes J, Costello R, Dalerba P, Diehn M, Dou J, Dylla SJ, Eyler CE, Fischer S, Garvalov BK, Ghiaur G, Gibbs CP, Gilbert CA, H. Niess, Haferlach T, Hochhaus A, Hosen N, Huff CA, Hurwitz H, Jiang X, Jones RJ, Jones RJ, Jones RJ, Ju Z, K.-W. Jauch, Kanamori M, Kiladjian JJ, Klonisch T, Kojima T, Korpal M, L. Zhao, Li C, Liu G, Liu R, Liu S, Lonardo E, Mauro MJ, McDermott SP, Merante S, Mimeault M, Moserle L, O’Brien SG, Park CY, Phillips TM, Platet N, Q. Bao, Rasheed ZA, Reya T, Reya T, Richardson GD, Roeder I, Seidel S, Singh A, Singh SK, Strojnik T, Stupp R, Suh MR, Szotek PP, Tang C, Tang M, Todaro M, Tu LC, Vermeulen L, Wilson BJ, Wright MH, Xu N, Y. Zhao, Yu F, Zhao C, Zhou BB   +82 more
core   +1 more source

Phosphoinositides Regulate Ciliary Protein Trafficking to Modulate Hedgehog Signaling [PDF]

Developmental Cell, 2015
Primary cilia interpret vertebrate Hedgehog (Hh) signals. Why cilia are essential for signaling is unclear. One possibility is that some forms of signaling require a distinct membrane lipid composition, found at cilia. We found that the ciliary membrane contains a particular phosphoinositide, PI(4)P, whereas a different phosphoinositide, PI(4,5)P2, is ...
Garcia-Gonzalo, F. R., Phua, S. C., Roberson, E. C., Garcia III, G., Abedin, M., Schurmans, Stéphane, Inoue, T, Reiter, J. F.   +7 more
openaire   +4 more sources

Hedgehog Acyltransferase Promotes Uptake of Palmitoyl-CoA across the Endoplasmic Reticulum Membrane

Cell Reports, 2019
Summary: Attachment of palmitate to the N terminus of Sonic hedgehog (Shh) is essential for Shh signaling. Shh palmitoylation is catalyzed on the luminal side of the endoplasmic reticulum (ER) by Hedgehog acyltransferase (Hhat), an ER-resident enzyme ...
James J. Asciolla, Marilyn D. Resh
doaj   +1 more source

Biophysical regulation of stem cell behavior within the niche. [PDF]

, 2012
Stem cells reside within most tissues throughout the lifetimes of mammalian organisms. To maintain their capacities for division and differentiation and thereby build, maintain, and regenerate organ structure and function, these cells require extensive ...
Conway, Anthony, Schaffer, David V
core   +1 more source

Dispatched protein releases Hedgehog from cells [PDF]

Genome Biology, 2000
A novel Drosophila segment polarity gene is identified and shown to be required for release of Hedgehog protein from secreting cells.
openaire   +1 more source

An amphioxus Gli gene reveals conservation of midline patterning and the evolution of hedgehog signalling diversity in chordates.

PLoS ONE, 2007
BackgroundHedgehog signalling, interpreted in receiving cells by Gli transcription factors, plays a central role in the development of vertebrate and Drosophila embryos. Many aspects of the signalling pathway are conserved between these lineages, however
Sebastian M Shimeld, Marcel van den Heuvel, Rebecca Dawber, James Briscoe   +3 more
doaj   +1 more source