Results 81 to 90 of about 100,157 (319)
Journal of Experimental & Clinical Cancer Research, 2020 Background The mechanism underlying sorafenib resistance in hepatocellular carcinoma (HCC) remains unclear. Accumulating evidence suggests that tumor-initiating cells (TICs) are a pivotal driving force. Both CD44 and Hedgehog signaling play crucial roles
Siqi Wang +8 more
doaj +1 more source
Proteome Science, 2023 Objective We investigated differentially expressed proteins (DEPs) in human glioblastoma U87 cells after treatment with hederagenin as a therapeutic screening mechanism and provided a theoretical basis for hederagenin in treating glioblastoma.
Yesen Zhang +4 more
doaj +1 more source
Post‐Translational Modifications in Cilia and Ciliopathies
Advanced Science, EarlyView.This review synthesizes current understanding of post‐translational modifications (PTMs) in ciliary proteins and emphasizes their roles in ciliary formation, homeostasis, and signaling. This review also discusses the implication of PTM dysregulation in ciliopathies and explores therapeutic strategies targeting PTM‐modifying enzymes.
Jie Ran, Jun Zhou
wiley +1 more source
PLoS ONE, 2007 BackgroundHedgehog signalling, interpreted in receiving cells by Gli transcription factors, plays a central role in the development of vertebrate and Drosophila embryos. Many aspects of the signalling pathway are conserved between these lineages, however
Sebastian M Shimeld +3 more
doaj +1 more source
Advanced Science, EarlyView.CCN1 modulates the tumor microenvironment in pancreatic cancer by promoting collagen‐dependent chemokine production, thereby facilitating immune evasion. Deletion of CCN1 not only suppresses tumor growth but also enhances immune cell infiltration and increases tumor sensitivity to both chemotherapy and immunotherapy.
Hongjie Fan +9 more
wiley +1 more source
Regulator of G-protein signaling - 5 (RGS5) is a novel repressor of hedgehog signaling. [PDF]
PLoS ONE, 2013 Hedgehog (Hh) signaling plays fundamental roles in morphogenesis, tissue repair, and human disease. Initiation of Hh signaling is controlled by the interaction of two multipass membrane proteins, patched (Ptc) and smoothened (Smo).
William M Mahoney +4 more
doaj +1 more source
Complete Conjugacy Invariants of Nonlinearizable Holomorphic Dynamics [PDF]
arXiv, 2009 Perez-Marco proved the existence of non-trivial totally invariant connected compacts called hedgehogs near the fixed point of a nonlinearizable germ of holomorphic diffeomorphism. We show that if two nonlinearisable holomorphic germs with a common indifferent fixed point have a common hedgehog then they must commute.
arxiv
Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis [PDF]
, 2018 Suppressor of Fused (SuFu), a tumour suppressor mutated in medulloblastoma, is a central player of Hh signalling, a pathway crucial for development and deregulated in cancer.
Alfonsi, Romina +22 more
core +5 more sources
Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine
Advanced Science, EarlyView.Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang +4 more
wiley +1 more source
Hedgehogs of Hausdorff dimension one [PDF]
arXiv, 2009 We present a construction of hedgehogs for holomorphic maps with an indifferent fixed point. We construct, for a family of commuting non-linearisable maps, a common hedgehog of Hausdorff dimension 1, the minimum possible.
arxiv