Regulation of Hedgehog Signaling by miRNAs and Nanoformulations: A Possible Therapeutic Solution for Colorectal Cancer [PDF]
, 2021 Zeeshan Javed +10 more
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American Journal of Medical Genetics Part A, EarlyView.ABSTRACT TSPEAR (chr. 21q22.3) encodes a protein involved in tooth development and is predominantly expressed in the enamel knot. Biallelic loss of function variants in TSPEAR cause ectodermal dysplasia, tooth agenesis and sensorineural hearing loss. However, the role of TSPEAR in auditory processes is unclear.
Debora Vergani +17 more
wiley +1 more source
Indian Hedgehog Suppresses a Stromal Cell–Driven Intestinal Immune Response
Cellular and Molecular Gastroenterology and Hepatology, 2018 Upon intestinal epithelial damage a complex wound healing response is initiated to restore epithelial integrity and defend against pathogenic invasion. Epithelium-derived Indian Hedgehog (Ihh) functions as a critical sensor in this process.
B. Florien Westendorp +16 more
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Genetic Activation of Hedgehog Signaling Unbalances the Rate of Neural Stem Cell Renewal by Increasing Symmetric Divisions [PDF]
, 2014 Julien Ferent +6 more
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The Anatomical Record, EarlyView.Abstract This study evaluated the morphogenesis of the temporomandibular joint (TMJ) in human fetuses during the third month of gestation through the analysis of immunohistochemistry for the proteins Indian Hedgehog (IHH), Patched‐1 (PTCH1), and Smoothened (SMO).
Filipe Santos da Silva +5 more
wiley +1 more source
Ontogeny of murine bony semicircular canal form
The Anatomical Record, EarlyView.Abstract The labyrinthine geometry and functional anatomy of the semicircular canals have intrigued scientists for decades, and there has been considerable interest in understanding how these complex structures grow and develop with evidence emerging from human studies that size maturation occurs exceptionally early by comparison with other systems ...
Marcela Cárdenas‐Serna +1 more
wiley +1 more source
Towards Modular Engineering of Cell Signalling: Topographically-Textured Microparticles Induce Osteogenesis via Activation of Canonical Hedgehog Signalling [PDF]
, 2023 Fatmah I. Ghuloum +4 more
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Gonadal development in scorpion mud‐turtles, Kinosternon scorpioides, in a controlled environment
The Anatomical Record, EarlyView.Stage 20 was identified as the critical point for gonadal differentiation in Kinosternon scorpioides, providing key insights into sex determination. These findings enhance conservation strategies by supporting reproductive management and population viability in both in situ and ex situ programs. Abstract Research on gonadal development including sexual
Brenda Braga +4 more
wiley +1 more source
Recent Advances in the Clinical Targeting of Hedgehog/GLI Signaling in Cancer
Cells, 2019 The Hedgehog/GLI signaling pathway plays an important role in normal embryonic tissue development and has been implicated in the pathogenesis of various human cancers.
Hao Xie +3 more
doaj +1 more source
Hedgehog Signaling Induces Cardiomyogenesis in P19 Cells [PDF]
, 2005 Peter J. Gianakopoulos +1 more
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