Results 191 to 200 of about 113,623 (349)

A subpopulation of astrocyte progenitors defined by Sonic hedgehog signaling [PDF]

, 2022
Ellen C. Gingrich, Kendra Case, A. Denise R. Garcia   +2 more
openalex   +1 more source

Targeting SPP1‐CD44‐Hedgehog Axis Elicits Therapeutic Effects in Hepatocellular Carcinoma by Suppressing Intratumoral Fibrosis

Cancer Science, EarlyView.
SPP1 was identified as a key driver of intratumoral fibrosis and hepatocellular carcinoma (HCC) progression through transcriptomic, histological, and functional analyses. Mechanistically, SPP1 promotes HSC activation and fibrosis via the SPP1–CD44–GLI1 axis, and pharmacologic inhibition of Hedgehog signaling effectively reduces tumor growth and ...
Atsushi Nara, Shu Shimada, Yoshimitsu Akiyama, Megumi Hatano, Yusuke Chino, Suguru Miyazawa, Hanako Tamura, Daisuke Asano, Yoshiya Ishikawa, Hiroki Ueda, Shuichi Watanabe, Eriko Katsuta, Keiichi Akahoshi, Kenichi Ohashi, Minoru Tanabe, Daisuke Ban, Shinji Tanaka   +16 more
wiley   +1 more source

Molecular Landscape in Limb Anomalies: Diagnostic Yield and New Candidate Genes

Clinical Genetics, EarlyView.
In 132 individuals with limb anomalies, diagnostic yield was 36% (47/132), including 25 novel variants, three cases with new phenotypes, and two candidate loci, HOXA11 and a small 2q31.1 deletion. Mouse data and exome‐wide analysis, key in identifying the candidate loci, represent an important opportunity for gene discovery.
Akram Mokhtari, Jade Charbonneau, Valancy Miranda, Khadijé Jizi, Marie‐Ange Delrue, Patricia Egerszegi, Isabelle Thiffault, Philippe M. Campeau   +7 more
wiley   +1 more source

Hedgehog signaling in humans: the HH_Signal pathway_db knowledge base. [PDF]

Vavilovskii Zhurnal Genet Selektsii
Bukharina TA, Bondarenko AM, Furman DP.
europepmc   +1 more source

Suppressing Wnt Signaling by the Hedgehog Pathway through sFRP-1

, 2006
Jing He, Tao Sheng, Arwen A. Stelter, Chengxin Li, Xiaoli Zhang, Mala Sinha, Bruce A. Luxon, Jingwu Xie   +7 more
openalex   +1 more source

Progressive tooth pattern changes in Cilk1-deficient mice depending on Hedgehog signaling. [PDF]

Int J Oral Sci
Kyeong M, Jeong JK, Adasooriya D, Kan S, Kim J, Song J, Park S, Je S, Moon SJ, Park YB, Ko HW, Cho ES, Cho SW.   +12 more
europepmc   +1 more source

Endocrine Resistance Score Based on Three Key Genes Predicts Prognosis and Reveals Potential Therapeutic Targets for ER+HER2− Breast Cancer

Cell Proliferation, EarlyView.
We generated endocrine‐resistant BC cell lines and identified CLEC3A, PCDH10, and ST3GAL1 as key endocrine‐resistant genes. More importantly, we validated their role in mediating resistance through PI3K‐AKT signalling and developed a predictive ERS with strong clinical relevance.
Liqin Ping, Lewei Zhu, Nian Chen, Xikun Liu, Jirui Zhong, Xiaoqing Sun, Hailin Tang, Kaiming Zhang   +7 more
wiley   +1 more source

Paracrine Hedgehog Signaling in Cancer [PDF]

, 2009
Jan-Willem Theunissen, Frédéric J. de Sauvage   +1 more
openalex   +1 more source

SnapShot: Hedgehog Signaling Pathway

Cell, 2007
Chen, Miao-Hsueh, Wilson, Christopher W., Chuang, Pao-Tien   +2 more
openaire   +2 more sources

Epigenetic regulation of TIPE3 in nasopharyngeal carcinoma and its impact on the hedgehog signaling pathway. [PDF]

Cell Mol Life Sci
Cheng Z, Fang Z, Yue K, Guo Y, Huang L, Zhang Y.   +5 more
europepmc   +1 more source