Results 211 to 220 of about 107,152 (254)

Sonic Hedgehog signaling in spinal cord injury: mechanisms and therapeutic implications. [PDF]

Front Mol Neurosci
Du M, Ji X, Chen W.
europepmc   +1 more source

Metformin as a Multifaceted Therapeutic Agent for Gastrointestinal Diseases: Mechanisms, Clinical Efficacy, and Future Directions

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT The high prevalence of gastrointestinal (GI) diseases and their significant impact on the quality of life require new therapeutic strategies. The development of novel therapeutic strategies should prioritize targeting the fundamental pathophysiological mechanisms underlying these diseases, including inflammation, cellular proliferation, and ...
Sayedeh Azimeh Hosseini, Hassan Valadbeigi, Seyedeh Mahdieh Khoshnazar, Saeed Khoshnood, Shahab Falahi, Delsuz Rezaee, Ali Hematian, Mohammad Hossein Haddadi   +7 more
wiley   +1 more source

New Insights into the Molecular Actions of Grosheimin, Costunolide, and α- and β-Cyclocostunolide on Primary Cilia Structure and Hedgehog Signaling. [PDF]

Int J Mol Sci
Murillo-Pineda M, Martínez-Miralles J, Medina-Calzada Z, Varela RM, Macías FA, Chinchilla N, Juárez-Soto Á, Santpere G, Reales E.   +8 more
europepmc   +1 more source

Single‐Cell Sequencing Reveals That CCL2+ Adipose‐Derived Stem Cells Promote Diabetic Wound Healing Through the CCL2‐ACKR1 Signaling Axis

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
scRNA‐seq of human adipose and diabetic wounds revealed a CCL2+ ADSC subpopulation with high stemness and ECM‐enriched pathways. These cells serve as a signaling hub via TGFB1‐TGFBR1, IL34‐CSF1R, and CCL2‐ACKR1. Their exosomes (CCL2‐Exos), carrying CCL2, TGFB1, and IL34, accelerate diabetic wound healing in mice by promoting angiogenesis, collagen ...
Songyun Zhao, Wanying Chen, Kaibo Liu, Jiaheng Xie, Yanming Chen, Hao Dai, Zhongqiu Lu, Longwang Chen, Yucang He, Hua Yu, Liqun Li   +10 more
wiley   +1 more source

MYB Activates the Hedgehog Signaling Pathway to Repress Natural Killer Cytotoxicity in Cervical Cancer. [PDF]

Kaohsiung J Med Sci
Wang Y, Li C.
europepmc   +1 more source

CNC–PNIPAM Drug Delivery System Improves Endometrial Receptivity via Natural Killer Cell Immune Tolerance in Endometriosis

Advanced NanoBiomed Research, EarlyView.
An injectable CNC–PNIPAM hydrogel is developed for intrauterine co‐delivery of levonorgestrel and botropase. This platform reprograms uterine natural killer cells toward an immune–tolerant phenotype and enhances endometrial receptivity marker expression. The results demonstrate a promising strategy to counteract endometriosis–associated infertility and
Zhou Liang, Yingjie Wang, Chenyu Bai, Pengfei Li, Xin He, Meng Ma, Xiaoying Luo, Yi Song, Yao Li, Yun Wang   +9 more
wiley   +1 more source

EVC protein regulates Sonic hedgehog signaling during human intervertebral disc development and degeneration. [PDF]

iScience
Wu Z, Shaw L, Dube CT, Ionescu AM, Qiu T, Tierney AL, Baird P, Patel S, Zeef LAH, Birchall LJ, Jennings RE, Hanley NA, Unwin RD, Hoyland JA, Richardson SM.   +14 more
europepmc   +1 more source

Garcinone C Suppresses Cancer Stem Cells and Induces Apoptosis in Triple‐Negative Breast Cancer Through Canonical Wnt Signaling

Food Frontiers, Volume 7, Issue 3, May 2026.
Garcinone C (Gar. C), a xanthone derived from mangosteen (Garcinia mangostana), suppresses triple‐negative breast cancer growth and stemness by inducing mitochondrial‐mediated apoptosis and inhibiting the Wnt/β‐catenin pathway, highlighting its potential as a natural compound for the prevention and treatment TNBC.
Danhong Zheng, Jiazi Chen, Yong Wang, Da Ma, Jing Chen   +4 more
wiley   +1 more source

The Role of Hedgehog Signaling in Non-small Cell Lung Cancer: Targeting Tumor Invasion, Therapy Resistance and Novel Therapeutic Strategies. [PDF]

Int J Biol Sci
Kang Y, Zheng H, Wen Q, Fan S.
europepmc   +1 more source

Targeted Therapy and Immunotherapies in Hepatocellular Carcinoma: Mechanisms and Clinical Studies

MedComm, Volume 7, Issue 5, May 2026.
The mechanism of multiple signaling pathways and their related targeted inhibitors in HCC. (A) The mechanism of Ras/Raf/MEK/ERK signaling pathway and its related targeted inhibitors; (B) the mechanism of PI3K/AKT/mTOR signaling pathway and its crosstalk with other pathways and its related targeted inhibitors; (C) the mechanism of JAK/STAT signaling ...
Penghui He, Sinan Xie, Kunlin Xie, Fengwei Gao, Yunshi Cai, Yan Huang, Chang Liu, Hong Wu, Yinghao Lyu, Tian Lan   +9 more
wiley   +1 more source