Results 231 to 240 of about 58,953 (264)
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American Journal of Medical Genetics Part A, 2010
AbstractIn vertebrate hedgehog signaling, hedgehog ligands are processed to become bilipidated and then multimerize, which allows them to leave the signaling cell via Dispatched 1 and become transported via glypicans and megalin to the responding cells.
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AbstractIn vertebrate hedgehog signaling, hedgehog ligands are processed to become bilipidated and then multimerize, which allows them to leave the signaling cell via Dispatched 1 and become transported via glypicans and megalin to the responding cells.
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Modulators of the hedgehog signaling pathway
Bioorganic & Medicinal Chemistry, 2010Since its discovery by C. Nüsslein-Volhard and E. F. Wieschaus, hedgehog (hh) signaling has come a long way. Today it is regarded as a key regulator in embryogenesis where it governs processes like cell proliferation, differentiation, and tissue patterning. Furthermore, in adults it is involved in the maintenance of stem cells, and in tissue repair and
Philipp, Heretsch +2 more
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Hedgehog: an unusual signal transducer
BioEssays, 2004AbstractHedgehog proteins are of pivotal importance for development and maintenance of tissue patterns in adult organisms. Despite the role of Hedgehogs in differentiation and tumorigenesis, signal transduction of Hedgehog remains a relatively uncharted area of signalling biochemistry.
Maarten F, Bijlsma +2 more
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Metabolites in vertebrate Hedgehog signaling
Biochemical and Biophysical Research Communications, 2014The Hedgehog (HH) signaling pathway is critical in embryonic development, stem cell biology, tissue homeostasis, chemoattraction and synapse formation. Irregular HH signaling is associated with a number of disease conditions including congenital disorders and cancer.
Hanne, Roberg-Larsen +3 more
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Patching the gaps in Hedgehog signalling
Nature Cell Biology, 2007The Hedgehog (Hh) pathway plays central roles in animal development and stem-cell function. Defects in Hh signalling lead to birth defects and cancer in humans. The first and often genetically damaged step in this pathway is the interaction between two membrane proteins - Patched (Ptc), encoded by a tumour suppressor gene, and Smoothened (Smo), encoded
Rajat, Rohatgi, Matthew P, Scott
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Running Interference for Hedgehog Signaling
Science Signaling, 2003The new technology of RNA interference (RNAi) is allowing high-throughput screening of cells to examine many biological processes. Michelson discusses one such system in which the Drosophila Hedgehog (Hh) pathway was analyzed by systematic genome-wide RNAi analysis. The results not only suggest unexpected overlap in
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Hedgehog signalling in vascular development
Angiogenesis, 2008The Hedgehog family of proteins are powerful morphogens mediating embryonic development as well as adult morphogenesis and carcinogenesis. For example, excess hedgehog activity has been implicated in basal cell carcinoma, medulloblastoma and rhabdomyosarcoma. More recently, hedgehog signalling has been implicated in angiogenesis.
Takashi, Nagase +3 more
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2012
Der Hedgehog Signaltransduktionsweg ist konserviert von der Fliege bis zum Menschen und spielt eine wichtige Rolle in vielen Entwicklungsprozessen. Anomale Aktivierung im Erwachsenen wurde mit vielen Krebsformen in Verbindung gebracht. Unser Labor demonstrierte vor Kurzem, dass die Aktivierung von Hedgehog in weißen Adipozyten der Maus zur ...
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Der Hedgehog Signaltransduktionsweg ist konserviert von der Fliege bis zum Menschen und spielt eine wichtige Rolle in vielen Entwicklungsprozessen. Anomale Aktivierung im Erwachsenen wurde mit vielen Krebsformen in Verbindung gebracht. Unser Labor demonstrierte vor Kurzem, dass die Aktivierung von Hedgehog in weißen Adipozyten der Maus zur ...
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The mechanism of hedgehog signal transduction
Biochemical Society Transactions, 2005Hedgehog (Hh) proteins are one of a small number of families of secreted signalling proteins that are responsible for cell interactions during development in many animals. As such, Hh signals produce many different responses at different times and in different cells.
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Phosphorylation Regulation of Hedgehog Signaling
2012The study of posttranslational regulation of proteins has occupied biochemists for well over a half century. Understanding balanced phosphorylation and dephosphorylation of the proteins may be the key to meeting some of the most pressing scientific challenges. A detailed examination of the phosphorylation of many components in the Hedgehog (Hh) pathway
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