Results 251 to 260 of about 956,727 (289)
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The hedgehog signaling network
American Journal of Medical Genetics Part A, 2003AbstractIn the hedgehog signaling network, mutations result in various phenotypes, including, among others, holoprosencephaly, nevoid basal cell carcinoma syndrome, Pallister‐Hall syndrome, Greig cephalopolysyndactyly, Rubinstein‐Taybi syndrome, isolated basal cell carcinoma, and medulloblastoma. Active Hedgehog ligand is double lipid modified with a C‐
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Hedgehog signaling and congenital malformations
Clinical Genetics, 2004The Hedgehog (Hh)‐signaling pathway is essential for numerous developmental processes inDrosophilaand vertebrate embryos. Hh signal transduction encompasses a complex series of regulatory events, including the generation of the mature Hh ligand, propagation of the ligand from source of production as well as the reception and interpretation of the ...
E, Nieuwenhuis, C-c, Hui
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Cellular and Molecular Life Sciences, 2000
Hedgehog signalling is a key regulator of embryonic development controlling proliferation and/or cell fate determination. With identification of the Hedgehog receptor PTCH1 as a tumour suppressor gene that underlies the human nevoid basal cell carcinoma syndrome (NBCCS), the Hedgehog signalling pathway was firmly linked to cancer.
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Hedgehog signalling is a key regulator of embryonic development controlling proliferation and/or cell fate determination. With identification of the Hedgehog receptor PTCH1 as a tumour suppressor gene that underlies the human nevoid basal cell carcinoma syndrome (NBCCS), the Hedgehog signalling pathway was firmly linked to cancer.
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Mechanisms of Hedgehog signalling in cancer
Growth Factors, 2011The Hedgehog (Hh) pathway is a conserved signalling system essential for embryonic development and for the maintenance of self-renewal pathways in progenitor cells. Mutations that deregulate Hh signalling are directly implicated in basal cell carcinoma and medulloblastoma. The mechanisms of Hh pathway activation in cancers in which no pathway mutations
Kieren D, Marini +3 more
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American Journal of Medical Genetics Part A, 2010
AbstractIn vertebrate hedgehog signaling, hedgehog ligands are processed to become bilipidated and then multimerize, which allows them to leave the signaling cell via Dispatched 1 and become transported via glypicans and megalin to the responding cells.
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AbstractIn vertebrate hedgehog signaling, hedgehog ligands are processed to become bilipidated and then multimerize, which allows them to leave the signaling cell via Dispatched 1 and become transported via glypicans and megalin to the responding cells.
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Metabolites in vertebrate Hedgehog signaling
Biochemical and Biophysical Research Communications, 2014The Hedgehog (HH) signaling pathway is critical in embryonic development, stem cell biology, tissue homeostasis, chemoattraction and synapse formation. Irregular HH signaling is associated with a number of disease conditions including congenital disorders and cancer.
Hanne, Roberg-Larsen +3 more
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2012
Der Hedgehog Signaltransduktionsweg ist konserviert von der Fliege bis zum Menschen und spielt eine wichtige Rolle in vielen Entwicklungsprozessen. Anomale Aktivierung im Erwachsenen wurde mit vielen Krebsformen in Verbindung gebracht. Unser Labor demonstrierte vor Kurzem, dass die Aktivierung von Hedgehog in weißen Adipozyten der Maus zur ...
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Der Hedgehog Signaltransduktionsweg ist konserviert von der Fliege bis zum Menschen und spielt eine wichtige Rolle in vielen Entwicklungsprozessen. Anomale Aktivierung im Erwachsenen wurde mit vielen Krebsformen in Verbindung gebracht. Unser Labor demonstrierte vor Kurzem, dass die Aktivierung von Hedgehog in weißen Adipozyten der Maus zur ...
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Running Interference for Hedgehog Signaling
Science Signaling, 2003The new technology of RNA interference (RNAi) is allowing high-throughput screening of cells to examine many biological processes. Michelson discusses one such system in which the Drosophila Hedgehog (Hh) pathway was analyzed by systematic genome-wide RNAi analysis. The results not only suggest unexpected overlap in
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The Hedgehog Signaling Pathway in Cancer
2005The Hedgehog (Hh) signaling pathway plays crucial roles during embryonic development, where it controls cell proliferation, differentiation, and tissue patterning in numerous tissues and organs (Ingham and McMahon 2001; Cohen 2003). Mutations in genes encoding key members of the pathway can result in many human developmental disorders, including ...
Janni, Vestergaard +2 more
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Modulators of the hedgehog signaling pathway
Bioorganic & Medicinal Chemistry, 2010Since its discovery by C. Nüsslein-Volhard and E. F. Wieschaus, hedgehog (hh) signaling has come a long way. Today it is regarded as a key regulator in embryogenesis where it governs processes like cell proliferation, differentiation, and tissue patterning. Furthermore, in adults it is involved in the maintenance of stem cells, and in tissue repair and
Philipp, Heretsch +2 more
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