Results 221 to 230 of about 58,953 (264)
New Insights into the Molecular Actions of Grosheimin, Costunolide, and α- and β-Cyclocostunolide on Primary Cilia Structure and Hedgehog Signaling. [PDF]
Int J Mol SciMurillo-Pineda M +8 more
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Network-based single-cell analysis identifies a proliferative GZMB<sup>+</sup> plasma cell subset linked to Hedgehog signaling and prognostic risk in lung squamous cell carcinoma. [PDF]
J Transl MedMa W +6 more
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The Role of Hedgehog Signaling in Non-small Cell Lung Cancer: Targeting Tumor Invasion, Therapy Resistance and Novel Therapeutic Strategies. [PDF]
Int J Biol SciKang Y, Zheng H, Wen Q, Fan S.
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Hedgehog Signaling in the Prostate
Journal of Urology, 2007Recent discoveries highlight the importance of the hedgehog signaling pathway in prostate growth regulation. We reviewed the role of hedgehog signaling in prostate development, adult prostate homeostasis and prostate cancer.A comprehensive review of all relevant literature was done.Epithelial expression of hedgehog ligand during prostate development ...
Aubie, Shaw, Wade, Bushman
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On the range of Hedgehog signaling
Current Opinion in Genetics & Development, 2000Hedgehog (Hh) is a secreted signaling protein that regulates the development of many organ systems. It can travel from its site of synthesis, a process that involves covalent attachment of cholesterol to its carboxyl terminus, proteins with putative sterol sensing domains in both sending and receiving cells, and glycosaminoglycans.
P T, Chuang, T B, Kornberg
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Science's STKE, 2007
The Hedgehog (Hh) signaling pathway is essential for development and tissue homeostasis in metazoans. Probably as a result of its potent influence on cell-fate outcomes, the Hh pathway when corrupted results in malformations and diseases such as cancer. Many of the pathway components that contribute to Hh-mediated signal transduction are presented.
Leni, Jacob, Lawrence, Lum
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The Hedgehog (Hh) signaling pathway is essential for development and tissue homeostasis in metazoans. Probably as a result of its potent influence on cell-fate outcomes, the Hh pathway when corrupted results in malformations and diseases such as cancer. Many of the pathway components that contribute to Hh-mediated signal transduction are presented.
Leni, Jacob, Lawrence, Lum
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The hedgehog signaling network
American Journal of Medical Genetics Part A, 2003AbstractIn the hedgehog signaling network, mutations result in various phenotypes, including, among others, holoprosencephaly, nevoid basal cell carcinoma syndrome, Pallister‐Hall syndrome, Greig cephalopolysyndactyly, Rubinstein‐Taybi syndrome, isolated basal cell carcinoma, and medulloblastoma. Active Hedgehog ligand is double lipid modified with a C‐
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Hedgehog signaling and congenital malformations
Clinical Genetics, 2004The Hedgehog (Hh)‐signaling pathway is essential for numerous developmental processes inDrosophilaand vertebrate embryos. Hh signal transduction encompasses a complex series of regulatory events, including the generation of the mature Hh ligand, propagation of the ligand from source of production as well as the reception and interpretation of the ...
E, Nieuwenhuis, C-c, Hui
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Cellular and Molecular Life Sciences, 2000
Hedgehog signalling is a key regulator of embryonic development controlling proliferation and/or cell fate determination. With identification of the Hedgehog receptor PTCH1 as a tumour suppressor gene that underlies the human nevoid basal cell carcinoma syndrome (NBCCS), the Hedgehog signalling pathway was firmly linked to cancer.
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Hedgehog signalling is a key regulator of embryonic development controlling proliferation and/or cell fate determination. With identification of the Hedgehog receptor PTCH1 as a tumour suppressor gene that underlies the human nevoid basal cell carcinoma syndrome (NBCCS), the Hedgehog signalling pathway was firmly linked to cancer.
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Mechanisms of Hedgehog signalling in cancer
Growth Factors, 2011The Hedgehog (Hh) pathway is a conserved signalling system essential for embryonic development and for the maintenance of self-renewal pathways in progenitor cells. Mutations that deregulate Hh signalling are directly implicated in basal cell carcinoma and medulloblastoma. The mechanisms of Hh pathway activation in cancers in which no pathway mutations
Kieren D, Marini +3 more
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