Results 201 to 210 of about 58,953 (264)

A living biobank of sarcoma patient‐derived cell cultures reveals multi‐omic and functional insights that capture disease heterogeneity

Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.
Preclinical models for sarcoma that preserve tumour biology are urgently needed to advance mechanistic understanding and functional precision oncology. 29 early‐passage patient‐derived sarcoma cell (PDC) cultures from 19 patients, representing 11 sarcoma subtypes were established and extensively characterized.
Stefanie Gijsels, Suzanne Fischer, David Creytens, Sándor Dedeyne, Felix De Vuyst, Cláudio Pinheiro, Fleur Cordier, Sarah‐Lee Bekaert, Nadine Van Roy, Kaat Durinck, Jarne Pauwels, Kris Gevaert, Pieter Mestdagh, Jo Vandesompele, Pekka Rappu, Jyrki Heino, An Hendrix, Gabrielle H. van Ramshorst, Gwen Sys, Olivier De Wever   +19 more
wiley   +1 more source

Ashwagandha (Withania somnifera) targets liver cancer stem cells via inhibiting Hedgehog signaling pathway in hepatocellular carcinoma. [PDF]

Med Oncol
Ismail SE, Youssef AI, Fawzy EE, Khalifa EA, Kazem AH, Kholief MA, Saleh ZA.   +6 more
europepmc   +1 more source

Regulators of Wnt Signaling Dkk‐1 and Notum Are Elevated in Pediatric ADHD

Developmental Neurobiology, Volume 86, Issue 3, July 2026.
ABSTRACT Wnt signaling has increasingly drawn attention in discussions of ADHD, yet the peripheral status of its upstream regulators remains largely uncharted. In this study, we examined circulating levels of four key modulators of this pathway—Dkk‐1, PORCN, Notum, and Tiki‐1—in a sample of children and adolescents with an ADHD diagnosis.
Fatma Coşkun, Ayşegül Metin Emre, İbrahim Kılınç, Ahmet Osman Kılıç   +3 more
wiley   +1 more source

The Prognostic Value of the Hedgehog Signaling Pathway in Ovarian Cancer. [PDF]

Int J Mol Sci
Salman ND, Hanker LC, Győrffy B, Bartha Á, Proppe L, Götte M.   +5 more
europepmc   +1 more source

R17 Drives Heparan Sulfate Clearance via Endolysosomal Trafficking

Israel Journal of Chemistry, Volume 66, Issue 4, July 2026.
R17 is a viral protein that binds heparan sulfate glycosaminoglycans and traffics them to the lysosome, leading to their degradation in a manner that does not require the presence of the cation‐independent mannose‐6‐phosphatre receptor. In BxPC3 pancreatic cancer cells, this loss in heparan sulfate results in the reduction of cell migration.
Pranali Bedekar, Alexander Lin, Abigail E. Reeves, Meg Critcher, Gil‐Suk Yang, Sean Hui, Daved H. Fremont, Mia L. Huang   +7 more
wiley   +1 more source

NFKBIE as a prognostic biomarker and therapeutic target for GBM: role in Hedgehog signaling activation. [PDF]

BMC Cancer
Mo F, Li Y, Dong C, Yang L, Ma X, Pan B, Fan Z.   +6 more
europepmc   +1 more source

Copepod community structure and physiological rates shape the biological pump during early North Atlantic spring bloom

Limnology and Oceanography, Volume 71, Issue 7, July 2026.
Abstract Zooplankton plays an important role in the biological carbon pump, and zooplankton biomass and community structure can have a large influence on the sedimentation/remineralization balance of the water column. We investigated the potential effects of zooplankton community structure and eco‐physiology on the export and attenuation of vertical ...
Marja Koski, Lene Mausson Pankoke
wiley   +1 more source

Transdifferentiation of endothelial progenitor cells into rhabdomyosarcoma defined by hedgehog signaling competence. [PDF]

Cell Rep
Gadek KE, Drummond CJ, Jin H, Garcia MR, Mathew ED, Adkins GE, Langdon CG, Evans M, Searcy MB, Schreiner P, Maguire M, Rehg JE, Ogden SK, Hatley ME.   +13 more
europepmc   +1 more source

Endoplasmic reticulum stress and the unfolded protein response in lung diseases: molecular pathways and therapeutic interventions

The Journal of Pathology, Volume 269, Issue 3, Page 268-283, July 2026.
Abstract Endoplasmic reticulum stress (ERS) occurs when the protein‐folding capacity of the endoplasmic reticulum (ER) is overwhelmed, triggering the unfolded protein response (UPR) to restore homeostasis. However, severe or persistent ERS can shift the UPR toward pro‐inflammatory, apoptotic, and fibrotic signaling, thereby exacerbating tissue injury ...
Lanlan Song, Yichen Liu, Chen Xu, Yaochen Zhang, Kaiming Xu, Dan Yao, Xiaoying Huang   +6 more
wiley   +1 more source

Lysosomal glucocerebrosidase is needed for ciliary Hedgehog signaling: A convergent pathway contributing to Parkinson's disease. [PDF]

Proc Natl Acad Sci U S A
Nair SV, Jaimon E, Adhikari A, Nikoloff J, Pfeffer SR.   +4 more
europepmc   +1 more source