Results 201 to 210 of about 107,152 (254)

Human‐derived cardiac‐neural microtissues reveal catecholaminergic polymorphic ventricular tachycardia is also a disease of the sympathetic neuron

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic diagram illustrating the proposed pathway in which regulatory defects might occur in sympathetic neurons derived from hiPSC in catecholaminergic polymorphic ventricular tachycardia (CPVT). Specifically, enhanced calcium transients appeared to derive from three sources: enhanced membrane excitability (due to loss of ...
Ni Li, Chenchen Zhang, Mengying Xu, YoonYoung Choi, Davi Sidarta‐Oliveira, Ruirui Dong, Xinyu Hu, Enrique M. Toledo, Cesar A. Prada‐Medina, Finbar Argus, Kun Liu, Mingyu Li, Linna Zhou, Hagan Bayley, Corey Smith, Chris Denning, Ana I. Domingos, Guoliang Hao, Dan Li, David J. Paterson   +19 more
wiley   +1 more source

The Prognostic Value of the Hedgehog Signaling Pathway in Ovarian Cancer. [PDF]

Int J Mol Sci
Salman ND, Hanker LC, Győrffy B, Bartha Á, Proppe L, Götte M.   +5 more
europepmc   +1 more source

Transdifferentiation of endothelial progenitor cells into rhabdomyosarcoma defined by hedgehog signaling competence. [PDF]

Cell Rep
Gadek KE, Drummond CJ, Jin H, Garcia MR, Mathew ED, Adkins GE, Langdon CG, Evans M, Searcy MB, Schreiner P, Maguire M, Rehg JE, Ogden SK, Hatley ME.   +13 more
europepmc   +1 more source

Whole Genome Sequence Analysis of Weight Loss in 16 972 Participants With COPD Reveals Novel Risk Loci in DRAIC and RFX3

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Background Chronic obstructive pulmonary disease (COPD) is associated with musculoskeletal comorbidities, including cachexia. Weight loss (WL) is the major criterion for cachexia and increases risk for mortality in COPD. Risk factors for WL in COPD are incompletely understood.
Joe W. Chiles III, Alison Rocco, Vinodh Srinivasasainagendra, Harry B. Rossiter, Richard Casaburi, Anna Thalacker‐Mercer, J. Michael Wells, Emily S. Wan, Edwin K. Silverman, Michael H. Cho, Craig P. Hersh, Bruce M. Psaty, Sina A. Gharib, Yan Gao, George T. O'Connor, Leslie A. Lange, Stephen S. Rich, Ani W. Manichaikul, R. Graham Barr, Victor E. Ortega, Deborah A. Meyers, Albert V. Smith, Hemant K. Tiwari, Merry‐Lynn N. McDonald   +23 more
wiley   +1 more source

SLC25A39 regulates Hedgehog signaling to promote tumor progression and sorafenib resistance in hepatocellular carcinoma. [PDF]

Sci Rep
Qiu Q, Yin H, Zhang L, Xu W, Zhu S, Zhang Q, Zhao M, Qian Y, Ruan Y, Zhang H, Wu Z, Liu J, Ke J, Dai Y, Wang W, Sun W, Gao Y, Xu H.   +17 more
europepmc   +1 more source

Deletion of a Pax1 Sex‐Associated Genomic Region Associated With Adolescent Idiopathic Scoliosis Leads to Disc Degeneration, Instability, and Vertebral Rotation in Mice

JOR SPINE, Volume 9, Issue 2, June 2026.
Overview of the effects of Pax1‐SAR deletion on gene expression, IVD degeneration, and resultant scoliotic‐like curvature between sexes. Proposed mechanism of sex‐dependent changes in gene expression in females (right) and males (left), resulting in sex‐dependent disc degeneration and scoliotic phenotypes.
Edward C. Moody, Emma M. Wade, Shuji Mizumoto, Jeremy McCallum‐Loudeac, Megan J. Wilson   +4 more
wiley   +1 more source

Lysosomal glucocerebrosidase is needed for ciliary Hedgehog signaling: A convergent pathway contributing to Parkinson's disease. [PDF]

Proc Natl Acad Sci U S A
Nair SV, Jaimon E, Adhikari A, Nikoloff J, Pfeffer SR.   +4 more
europepmc   +1 more source

Redox Regulation and Oxidative Stress in Health and Disease: Mechanisms and Therapeutic Targeting

MedComm – Future Medicine, Volume 5, Issue 2, June 2026.
Reactive species serve crucial roles which are tightly regulated in both physiological as well as disease states. At physiological levels, these species are integral to redox signaling, while uncontrolled redox promotes disease pathology. This review examines the dysregulation of these processes.
Mohammad Hossein Azadi, Azadeh Niknejad, Elaheh Amini   +2 more
wiley   +1 more source

Hydrogen sulfide promotes proliferation and regeneration of human cerebral microvascular endothelial cells via the sonic hedgehog signaling pathway. [PDF]

Open Life Sci
Chen HY, Huang JM, Zheng P, Yang GX, Qin BB, Zang MX, Wang J, Li XB.   +7 more
europepmc   +1 more source

Colorectal Precancerous Lesions: Molecular Mechanisms, Research Tools, and Natural Product‐Based Clinical Translation

MedComm – Oncology, Volume 5, Issue 2, June 2026.
This article systematically elucidates the molecular mechanisms of colorectal precancerous lesions, introduces cutting‐edge research tools like multi‐omics and organoids, and highlights the potential and prospects of natural products such as berberine, resveratrol, and curcumin in preventing and intervening in colorectal carcinogenesis by modulating ...
Shunji Liu, Chujuan Cui, Lingdong Kong, Qiang Xu, Haibo Cheng, Lisha Zhou, Yang Sun   +6 more
wiley   +1 more source