Results 21 to 30 of about 113,623 (349)
Cooperative Hedgehog-EGFR signaling [PDF]
Frontiers in Bioscience, 2012 It has been known for many years that cooperative interactions between oncogenes (e.g. RAS, MYC, BCL2) can fuel cancer growth (1-5), but the restricted druggability of many of those interacting cancer genes has hampered translation of combined targeting to medical cancer therapy.
Doris, Mangelberger +4 more
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Lipid metabolism fattens up hedgehog signaling
BMC Biology, 2017 Signaling pathways direct organogenesis, often through concentration-dependent effects on cells. The hedgehog pathway enables cells to sense and respond to hedgehog ligands, of which the best studied is sonic hedgehog. Hedgehog signaling is essential for
Robert Blassberg, John Jacob
doaj +1 more source
Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression. [PDF]
, 2016 Gastrointestinal stromal tumors (GIST) arise within the interstitial cell of Cajal (ICC) lineage due to activating KIT/PDGFRA mutations. Both ICC and GIST possess primary cilia (PC), which coordinate PDGFRA and Hedgehog signaling, regulators of ...
Bardsley, Michael R +18 more
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Patched receptors sense, interpret and establish an epidermal Hedgehog signalling gradient [PDF]
, 2016 By using the sensitivity of single-molecule fluorescent in situ hybridization, we have precisely quantified the levels and defined the temporal and spatial distribution of Hedgehog signaling activity during embryonic skin development and discovered that ...
Adolphe, Christelle +4 more
core +2 more sources
Research progress on the mechanism of the Hedgehog signaling pathway during mandibular development [PDF]
口腔疾病防治The source and process of mandible development are significantly different from those of other bones in the body, and abnormal development can lead to various bone-related diseases, seriously affecting the quality of life of patients.
XU Yao, LI Wenjin
doaj +1 more source
Sonic Hedgehog Is a Member of the Hh/DD-Peptidase Family That Spans the Eukaryotic and Bacterial Domains of Life. [PDF]
, 2018 Sonic Hedgehog (Shh) coordinates Zn2+ in a manner that resembles that of peptidases. The ability of Shh to undergo autoproteolytic processing is impaired in mutants that affect the Zn2+ coordination, while mutating residues essential for catalytic ...
Roelink, Henk
core +3 more sources
Hedgehog Signaling in Hematopoiesis [PDF]
Critical Reviews™ in Eukaryotic Gene Expression, 2010 The Hedgehog signaling pathway is highly conserved and plays an essential role in the embryonic development of a wide variety of organs. In adult tissues, such as the central nervous system, it may also be required for homeostasis and repair following injury. The role of Hedgehog signaling in regulating hematopoiesis is not entirely clear. Evidence has
Yiting, Lim, William, Matsui
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The emerging roles of phosphatases in Hedgehog pathway
Cell Communication and Signaling, 2017 Hedgehog signaling is evolutionarily conserved and plays a pivotal role in cell fate determination, embryonic development, and tissue renewal. As aberrant Hedgehog signaling is tightly associated with a broad range of human diseases, its activities must ...
Long Zhao +4 more
doaj +1 more source
Hedgehog signaling in cholangiocytes [PDF]
Current Opinion in Gastroenterology, 2011 Cells lining the biliary tree are targets of injury, but also orchestrate liver repair. The latter involves autocrine/paracrine signaling that enhances the viability and growth of residual ductular cells and promotes accumulation of inflammatory and myofibroblastic cells.
Alessia, Omenetti, Anna Mae, Diehl
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Cell Reports, 2017 Summary: Colon cancer is a heterogeneous tumor driven by a subpopulation of cancer stem cells (CSCs). To study CSCs in colon cancer, we used limiting dilution spheroid and serial xenotransplantation assays to functionally define the frequency of CSCs in ...
Joseph L. Regan +13 more
doaj +1 more source