Results 21 to 30 of about 4,665,048 (250)
Development, 2016 The Hedgehog (Hh) signalling pathway is one of the key regulators of metazoan development. Hh proteins have been shown to play roles in many developmental processes and have become paradigms for classical morphogens. Dysfunction of the Hh pathway underlies a number of human developmental abnormalities and diseases, making it an important therapeutic ...
Lee, Raymond Teck Ho +2 more
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Hippo signaling activates hedgehog signaling by Taz-driven Gli3 processing
Cell Regeneration, 2023 The overlapping roles of Hippo and Hedgehog signaling in biological functions and diseases prompt us to investigate their potential interactions. Activation of Hippo signaling enhances the transcriptional output of Hedgehog signaling, and the role of ...
Chao Tang +7 more
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Development, 2021 The mechanisms of vertebrate Hedgehog signaling are linked to the biology of the primary cilium, an antenna-like organelle that projects from the surface of most vertebrate cell types.
Emily K. Ho, T. Stearns
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Frontiers in Endocrinology, 2023 Hedgehog signaling plays pivotal roles in embryonic development, adult homeostasis and tumorigenesis. However, its engagement in the pituitary gland has been long underestimated although Hedgehog signaling and pituitary embryogenic development are ...
Yehan Bian, Heidi Hahn, Anja Uhmann
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Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling
Molecular Cancer, 2021 Hepatocellular carcinoma (HCC) is one of the most intractable tumors in the world due to its high rate of recurrence and heterogeneity. Liver cancer initiating cells also called cancer stem cells (CSCs) play a critical role in resistance against typical ...
Yang Gu +10 more
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Maintenance of Taste Organs Is Strictly Dependent on Epithelial Hedgehog/GLI Signaling. [PDF]
PLoS Genetics, 2016 For homeostasis, lingual taste papilla organs require regulation of epithelial cell survival and renewal, with sustained innervation and stromal interactions.
Alexandre N Ermilov +7 more
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The you gene encodes an EGF-CUB protein essential for Hedgehog signaling in zebrafish. [PDF]
PLoS Biology, 2005 Hedgehog signaling is required for many aspects of development in vertebrates and invertebrates. Misregulation of the Hedgehog pathway causes developmental abnormalities and has been implicated in certain types of cancer.
Ian G Woods, William S Talbot
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Cells, 2022 The Hedgehog signaling pathway regulates many processes during embryogenesis and the homeostasis of adult organs. Recent data suggest that central metabolic processes and signaling cascades in the liver are controlled by the Hedgehog pathway and that ...
Fritzi Ott +12 more
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Hedgehog signaling in the stomach [PDF]
Current Opinion in Pharmacology, 2016 The Hedgehog (Hh) signaling pathway not only plays a key part in controlling embryonic development, but in the adult stomach governs important cellular events such as epithelial cell differentiation, proliferation, gastric disease, and regeneration. In particular, Sonic Hedgehog (Shh) signaling has been well studied for its role in gastric physiology ...
Daniel Konstantinou +2 more
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Activation of hedgehog signaling is not a frequent event in ovarian cancers
Molecular Cancer, 2009 The hedgehog (Hh) signaling pathway regulates many processes of development and tissue homeostasis. Activation of hedgehog signaling has been reported in about 30% of human cancer including ovarian cancer.
Zhang Xiaoli +7 more
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