Results 41 to 50 of about 58,964 (166)

Activation of the hedgehog pathway in advanced prostate cancer

Molecular Cancer, 2004
Background The hedgehog pathway plays a critical role in the development of prostate. However, the role of the hedgehog pathway in prostate cancer is not clear. Prostate cancer is the second most prevalent cause of cancer death in American men. Therefore,
McCormick Frank, Chen Kai, He Nonggao, Chi Sumin, Zhang Xiaoli, Li Chengxin, Sheng Tao, Gatalica Zoran, Xie Jingwu   +8 more
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Loss of Sonic hedgehog leads to alterations in intestinal secretory cell maturation and autophagy. [PDF]

PLoS ONE, 2014
Intestinal epithelial cells express the Sonic and Indian hedgehog ligands. Despite the strong interest in gut hedgehog signaling in GI diseases, no studies have specifically addressed the singular role of intestinal epithelial cell Sonic hedgehog ...
Jessica Gagné-Sansfaçon, Joannie M Allaire, Christine Jones, François Boudreau, Nathalie Perreault   +4 more
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mTORC1 hampers Hedgehog signaling in Tsc2 deficient cells

Life Science Alliance
This is the first demonstration that mTORC1 inhibits Hedgehog signaling. mTORC1 prevents cilia accumulation of Smo and activation of GlI2. Also, evidence is provided for a 2-step activation process of GLI2.
Lasse Jonsgaard Larsen, Elsebet Østergaard, Lisbeth Birk Møller   +2 more
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Sox17 Promotes Oligodendrocyte Regeneration by Dual Modulation of Hedgehog and Wnt Signaling

iScience, 2020
Summary: Signaling pathways that promote oligodendrocyte development improve oligodendrocyte regeneration and myelin recovery from demyelinating pathologies.
Xiaotian Ming, Jeffrey L. Dupree, Vittorio Gallo, Li-Jin Chew   +3 more
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The role of Hedgehog and Notch signaling pathway in cancer

Molecular Biomedicine, 2022
Notch and Hedgehog signaling are involved in cancer biology and pathology, including the maintenance of tumor cell proliferation, cancer stem-like cells, and the tumor microenvironment.
Ruolan Xia, Maosen Xu, Jing Yang, Xuelei Ma   +3 more
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Role of GSK-3β in the osteogenic differentiation of palatal mesenchyme.

PLoS ONE, 2011
IntroductionThe function of Glycogen Synthase Kinases 3β (GSK-3β) has previously been shown to be necessary for normal secondary palate development. Using GSK-3ß null mouse embryos, we examine the potential coordinate roles of Wnt and Hedgehog signaling ...
Emily R Nelson, Benjamin Levi, Michael Sorkin, Aaron W James, Karen J Liu, Natalina Quarto, Michael T Longaker   +6 more
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Ethanol Effects on Early Developmental Stages Studied Using the Zebrafish

Biomedicines, 2022
Fetal alcohol spectrum disorder (FASD) results from prenatal ethanol exposure. The zebrafish (Danio rerio) is an outstanding in vivo FASD model. Early development produced the three germ layers and embryonic axes patterning.
Priyadharshini Manikandan, Swapnalee Sarmah, James A. Marrs   +2 more
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Hedgehog Signaling and Embryonic Craniofacial Disorders

Journal of Developmental Biology, 2019
Since its initial discovery in a Drosophila mutagenesis screen, the Hedgehog pathway has been revealed to be instrumental in the proper development of the vertebrate face. Vertebrates possess three hedgehog paralogs: Sonic hedgehog (Shh), Indian hedgehog
John Abramyan
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Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover.

PLoS Biology, 2013
Hedgehog signaling plays conserved roles in controlling embryonic development; its dysregulation has been implicated in many human diseases including cancers.
Shoujun Huang, Zhao Zhang, Chunxia Zhang, Xiangdong Lv, Xiudeng Zheng, Zhenping Chen, Liwei Sun, Hailong Wang, Yuanxiang Zhu, Jing Zhang, Shuyan Yang, Yi Lu, Qinmiao Sun, Yi Tao, Feng Liu, Yun Zhao, Dahua Chen   +16 more
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Research progress on the role of Hedgehog signaling pathway in renal interstitial fibrosis

Linchuang shenzangbing zazhi, 2020
Renal interstitial fibrosis is the common progressive pathway for many chronic kidney diseases.The activation of Hedgehog signaling pathway seems to play an important role in progression of chronic kidney diseases as much as in embryonic renal ...
ZHOU Lan-qi, ZHOU Jian-hua
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