Results 41 to 50 of about 956,727 (289)

Hedgehog inhibition promotes a switch from Type II to Type I cell death receptor signaling in cancer cells. [PDF]

PLoS ONE, 2011
TRAIL is a promising therapeutic agent for human malignancies. TRAIL often requires mitochondrial dysfunction, referred to as the Type II death receptor pathway, to promote cytotoxicity.
Satoshi Kurita, Justin L Mott, Sophie C Cazanave, Christian D Fingas, Maria E Guicciardi, Steve F Bronk, Lewis R Roberts, Martin E Fernandez-Zapico, Gregory J Gores   +8 more
doaj   +1 more source

Hedgehog signaling pathway as a potential target in the treatment of advanced gastric cancer

Tumor Biology, 2017
The sonic hedgehog signaling pathway is critical for cell proliferation, cell differentiation, and organ development during embryogenesis. Aberrant activation of the sonic hedgehog pathway has been associated with a variety of human cancers.
Dae-Hee Lee, Suk-young Lee, Sang Cheul Oh   +2 more
doaj   +1 more source

Hedgehog Signaling: An Achilles’ Heel in Cancer

Translational Oncology, 2019
Hedgehog signaling pathway originally identified in the fruit fly Drosophila is an evolutionarily conserved signaling mechanism with crucial roles in embryogenesis, growth and patterning. It exerts its biological effect through a signaling mechanism that
Madiha Niyaz, Mosin S Khan, Syed Mudassar   +2 more
doaj   +1 more source

Meningioma cells express primary cilia but do not transduce ciliary Hedgehog signals

Acta Neuropathologica Communications, 2020
Meningiomas are the most common primary intracranial tumors, but treatment options for meningioma patients are limited due to incomplete understanding of tumor biology.
Sarah Findakly, Abrar Choudhury, Vikas Daggubati, Melike Pekmezci, Ursula E. Lang, David R. Raleigh   +5 more
doaj   +1 more source

Promotion of Cancer Cell Proliferation by Cleaved and Secreted Luminal Domains of ER Stress Transducer BBF2H7. [PDF]

PLoS ONE, 2015
BBF2H7 is an endoplasmic reticulum (ER)-resident transmembrane basic leucine zipper (bZIP) transcription factor that is cleaved at the transmembrane domain by regulated intramembrane proteolysis in response to ER stress.
Hideo Iwamoto, Koji Matsuhisa, Atsushi Saito, Soshi Kanemoto, Rie Asada, Kenta Hino, Tomoko Takai, Min Cui, Xiang Cui, Masayuki Kaneko, Koji Arihiro, Kazuhiko Sugiyama, Kaoru Kurisu, Akio Matsubara, Kazunori Imaizumi   +14 more
doaj   +1 more source

Hedgehog Morphogens Act as Growth Factors Critical to Pre- and Postnatal Cardiac Development and Maturation: How Primary Cilia Mediate Their Signal Transduction

Cells, 2022
Primary cilia are crucial for normal cardiac organogenesis via the formation of cyto-architectural, anatomical, and physiological boundaries in the developing heart and outflow tract.
Lindsey A. Fitzsimons, Victoria L. Brewer, Kerry L. Tucker   +2 more
doaj   +1 more source

Hedgehog signaling in the liver

Journal of Hepatology, 2011
Reactivation of Hedgehog (Hh), a morphogenic signaling pathway that controls progenitor cell fate and tissue construction during embryogenesis occurs during many types of liver injury in adult. The net effects of activating the Hedgehog pathway include expansion of liver progenitor populations to promote liver regeneration, but also hepatic ...
Omenetti, Alessia, Choi, Steve, Michelotti, Gregory, Diehl, Anna Mae   +3 more
openaire   +2 more sources

The Roles of Hedgehog Signaling Pathway in Radioresistance of Cervical Cancer

Dose-Response, 2019
Radiotherapy is an important treatment of cervical cancer, especially for advanced cervical cancer. According to research reports, Hedgehog signaling pathway plays an essential role in the growth, invasion, metastasis, recurrence, drug resistance, and ...
Chang Liu, Rensheng Wang
doaj   +1 more source

Cooperative Hedgehog-EGFR signaling [PDF]

Frontiers in Bioscience, 2012
It has been known for many years that cooperative interactions between oncogenes (e.g. RAS, MYC, BCL2) can fuel cancer growth (1-5), but the restricted druggability of many of those interacting cancer genes has hampered translation of combined targeting to medical cancer therapy.
Doris, Mangelberger, Daniela, Kern, Andrea, Loipetzberger, Markus, Eberl, Fritz, Aberger   +4 more
openaire   +2 more sources

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source