Results 51 to 60 of about 58,670 (165)

Research progress on the role of Hedgehog signaling pathway in renal interstitial fibrosis

Linchuang shenzangbing zazhi, 2020
Renal interstitial fibrosis is the common progressive pathway for many chronic kidney diseases.The activation of Hedgehog signaling pathway seems to play an important role in progression of chronic kidney diseases as much as in embryonic renal ...
ZHOU Lan-qi, ZHOU Jian-hua
doaj  

Hedgehog Signaling Promotes the Proliferation and Subsequent Hair Cell Formation of Progenitor Cells in the Neonatal Mouse Cochlea

Frontiers in Molecular Neuroscience, 2017
Hair cell (HC) loss is the major cause of permanent sensorineural hearing loss in mammals. Unlike lower vertebrates, mammalian cochlear HCs cannot regenerate spontaneously after damage, although the vestibular system does maintain limited HC regeneration
Yan Chen, Yan Chen, Xiaoling Lu, Xiaoling Lu, Luo Guo, Luo Guo, Wenli Ni, Wenli Ni, Yanping Zhang, Yanping Zhang, Liping Zhao, Liping Zhao, Lingjie Wu, Lingjie Wu, Shan Sun, Shan Sun, Shasha Zhang, Mingliang Tang, Wenyan Li, Wenyan Li, Renjie Chai, Renjie Chai, Renjie Chai, Huawei Li, Huawei Li, Huawei Li, Huawei Li, Huawei Li   +27 more
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Morphogenetic Signalling: Responses to Hedgehog [PDF]

Current Biology, 1995
Protein kinase A activity is required for signalling by the extracellular molecule Hedgehog in developing Drosophila imaginal discs, but does the kinase actually respond to the Hedgehog signal?
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A Polyamine Twist on Hedgehog Signaling [PDF]

Developmental Cell, 2015
The Hedgehog pathway plays important roles in embryonic development and oncogenesis, but how it affects metabolism is less clear. D'Amico et al. (2015) now demonstrate that the Hedgehog pathway regulates translation of ornithine decarboxylase, thereby enhancing polyamine biosynthesis and cell proliferation in neural precursor cells and in brain tumors.
Zhao, Xuesong, Segal, Rosalind A.
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Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover.

PLoS Biology, 2013
Hedgehog signaling plays conserved roles in controlling embryonic development; its dysregulation has been implicated in many human diseases including cancers.
Shoujun Huang, Zhao Zhang, Chunxia Zhang, Xiangdong Lv, Xiudeng Zheng, Zhenping Chen, Liwei Sun, Hailong Wang, Yuanxiang Zhu, Jing Zhang, Shuyan Yang, Yi Lu, Qinmiao Sun, Yi Tao, Feng Liu, Yun Zhao, Dahua Chen   +16 more
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Autocrine Sonic hedgehog attenuates inflammation in cerulein-induced acute pancreatitis in mice via upregulation of IL-10. [PDF]

PLoS ONE, 2012
Hedgehog signaling plays critical roles in pancreatic oncogenesis and chronic pancreatitis, but its roles in acute pancreatitis (AP) are largely ambiguous.
Xiangyu Zhou, Zhiqiang Liu, Feng Jang, Chuannan Xiang, Yuan Li, Yanzheng He   +5 more
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Cooperative Hedgehog-EGFR signaling [PDF]

Frontiers in Bioscience, 2012
It has been known for many years that cooperative interactions between oncogenes (e.g. RAS, MYC, BCL2) can fuel cancer growth (1-5), but the restricted druggability of many of those interacting cancer genes has hampered translation of combined targeting to medical cancer therapy.
Doris, Mangelberger, Daniela, Kern, Andrea, Loipetzberger, Markus, Eberl, Fritz, Aberger   +4 more
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Cholesterol accessibility at the ciliary membrane controls hedgehog signaling

eLife, 2019
Previously we proposed that transmission of the hedgehog signal across the plasma membrane by Smoothened is triggered by its interaction with cholesterol (Luchetti et al., 2016).
Maia Kinnebrew, Ellen J Iverson, Bhaven B Patel, Ganesh V Pusapati, Jennifer H Kong, Kristen A Johnson, Giovanni Luchetti, Kaitlyn M Eckert, Jeffrey G McDonald, Douglas F Covey, Christian Siebold, Arun Radhakrishnan, Rajat Rohatgi   +12 more
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Gli2, hedgehog and TCR signalling

Oncotarget, 2015
A structurally and functionally diverse T-cell repertoire is essential for each of the key roles of the adaptive immune system: elimination of foreign pathogens, provision of immunological memory and the maintenance of tolerance to self. T-cells develop in the thymus and then migrate to the periphery where they undergo activation and functional ...
Furmanski, Anna L., Crompton, Tessa
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Hedgehog Signaling in Endochondral Ossification [PDF]

Journal of Developmental Biology, 2016
Hedgehog (Hh) signaling plays crucial roles in the patterning and morphogenesis of various organs within the bodies of vertebrates and insects. Endochondral ossification is one of the notable developmental events in which Hh signaling acts as a master regulator.
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