Results 51 to 60 of about 58,964 (166)
SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts
Nature Communications, 2021 Hedgehog signaling is essential for bone formation. Here, the authors show that the transmembrane protein SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts, suggesting it may be a potential therapeutic target to enhance bone formation.
Jun Sun +17 more
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Hedgehog Signaling: An Arrestin Connection? [PDF]
Current Biology, 2005 Arrestins are best known for terminating signaling by G protein coupled receptors. New binding, localization and genetic studies suggest that Arrestins may also participate in the transduction of Hedgehog signals by the seven transmembrane domain protein, Smoothened.
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Frontiers in Molecular Neuroscience, 2017 Hair cell (HC) loss is the major cause of permanent sensorineural hearing loss in mammals. Unlike lower vertebrates, mammalian cochlear HCs cannot regenerate spontaneously after damage, although the vestibular system does maintain limited HC regeneration
Yan Chen +27 more
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Autocrine Sonic hedgehog attenuates inflammation in cerulein-induced acute pancreatitis in mice via upregulation of IL-10. [PDF]
PLoS ONE, 2012 Hedgehog signaling plays critical roles in pancreatic oncogenesis and chronic pancreatitis, but its roles in acute pancreatitis (AP) are largely ambiguous.
Xiangyu Zhou +5 more
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Morphogenetic Signalling: Responses to Hedgehog [PDF]
Current Biology, 1995 Protein kinase A activity is required for signalling by the extracellular molecule Hedgehog in developing Drosophila imaginal discs, but does the kinase actually respond to the Hedgehog signal?
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Paracrine Hedgehog Signaling in Cancer [PDF]
Cancer Research, 2009 Abstract Ligand-dependent and ligand-independent activation of the Hedgehog (Hh) signaling pathway is involved in tumorigenesis. The importance of mutations in Hh pathway components leading to constitutive signaling has been well established in basal cell carcinoma and medulloblastoma.
Jan-Willem, Theunissen +1 more
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A Polyamine Twist on Hedgehog Signaling [PDF]
Developmental Cell, 2015 The Hedgehog pathway plays important roles in embryonic development and oncogenesis, but how it affects metabolism is less clear. D'Amico et al. (2015) now demonstrate that the Hedgehog pathway regulates translation of ornithine decarboxylase, thereby enhancing polyamine biosynthesis and cell proliferation in neural precursor cells and in brain tumors.
Zhao, Xuesong, Segal, Rosalind A.
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Cholesterol accessibility at the ciliary membrane controls hedgehog signaling
eLife, 2019 Previously we proposed that transmission of the hedgehog signal across the plasma membrane by Smoothened is triggered by its interaction with cholesterol (Luchetti et al., 2016).
Maia Kinnebrew +12 more
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Gli2, hedgehog and TCR signalling
Oncotarget, 2015 A structurally and functionally diverse T-cell repertoire is essential for each of the key roles of the adaptive immune system: elimination of foreign pathogens, provision of immunological memory and the maintenance of tolerance to self. T-cells develop in the thymus and then migrate to the periphery where they undergo activation and functional ...
Furmanski, Anna L., Crompton, Tessa
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Neural Regeneration ResearchRecent studies have shown that fibrotic scar formation following cerebral ischemic injury has varying effects depending on the microenvironment. However, little is known about how fibrosis is induced and regulated after cerebral ischemic injury.
Jun Wen +16 more
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