Results 31 to 40 of about 956,727 (289)
Hedgehog Signaling in Myeloid Malignancies [PDF]
Cancers, 2021 Myeloid malignancies arise from normal hematopoiesis and include several individual disorders with a wide range of clinical manifestations, treatment options, and clinical outcomes. The Hedgehog (HH) signaling pathway is aberrantly activated in many of these diseases, and glasdegib, a Smoothened (SMO) antagonist and HH pathway inhibitor, has recently ...
Ajay Abraham, William Matsui
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Cell Reports, 2017 Summary: Colon cancer is a heterogeneous tumor driven by a subpopulation of cancer stem cells (CSCs). To study CSCs in colon cancer, we used limiting dilution spheroid and serial xenotransplantation assays to functionally define the frequency of CSCs in ...
Joseph L. Regan +13 more
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Transducing the Hedgehog Signal [PDF]
Cell, 2000 Regardless of the status of Smo/Ptc associations, we now have to consider which, if any, of the newly found responses of Smo to Hh actually determine Smo signaling activity. As there really are no definitive data to guide us here, I will take the opportunity to discuss some possibilities.
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Journal of Experimental & Clinical Cancer Research, 2020 Background The mechanism underlying sorafenib resistance in hepatocellular carcinoma (HCC) remains unclear. Accumulating evidence suggests that tumor-initiating cells (TICs) are a pivotal driving force. Both CD44 and Hedgehog signaling play crucial roles
Siqi Wang +8 more
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Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling [PDF]
Nature Chemical Biology, 2013 Inhibition of Sonic hedgehog (Shh) signaling is of great clinical interest. Here we exploit Hedgehog acyltransferase (Hhat)-mediated Shh palmitoylation, a modification critical for Shh signaling, as a new target for Shh pathway inhibition. A target-oriented high-throughput screen was used to identify small-molecule inhibitors of Hhat.
Petrova, Elissaveta +4 more
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The presynaptic glycine transporter GlyT2 is regulated by the Hedgehog pathway in vitro and in vivo
Communications Biology, 2021 By modulating the activation state of the Hedgehog pathway, de la Rocha-Muñoz et al demonstrate that Hedgehog signaling controls the expression and transport activity of the neuronal glycine transporter GlyT2.
Andrés de la Rocha-Muñoz +8 more
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Temporal-spatial changes in Sonic Hedgehog expression and signaling reveal different potentials of ventral mesencephalic progenitors to populate distinct ventral midbrain nuclei [PDF]
, 2011 Background: The ventral midbrain contains a diverse array of neurons, including dopaminergic neurons of the ventral tegmental area (VTA) and substantia nigra (SN) and neurons of the red nucleus (RN).
Joyner, Alexandra L. +33 more
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Hedgehog signaling in skin cancers [PDF]
Cellular Signalling, 2011 An increasing progress on the role of Hedgehog (Hh) signaling for carcinogenesis has been achieved since the link of Hh pathway to human cancer was firstly established. In particular, the critical role of Hh signaling in the development of Basal cell carcinoma (BCC) has been convincingly demonstrated by genetic mutation analyses, mouse models of BCCs ...
Chengxin, Li, Sumin, Chi, Jingwu, Xie
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Regulation of Gli proteins by the Hedgehog Signaling Pathway [PDF]
, 2013 Hedgehog signaling is essential during embryogenesis and in the maintenance of ...
Lopez, Lyle Villamater
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Hedgehog Signaling in Organogenesis and Tumor Microenvironment [PDF]
, 2020 The Hedgehog signaling pathway is an evolutionarily conserved pathway that governs complex developmental processes, including stem cell maintenance, proliferation, differentiation, and patterning.
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