Results 31 to 40 of about 58,670 (165)

Promotion of Cancer Cell Proliferation by Cleaved and Secreted Luminal Domains of ER Stress Transducer BBF2H7. [PDF]

PLoS ONE, 2015
BBF2H7 is an endoplasmic reticulum (ER)-resident transmembrane basic leucine zipper (bZIP) transcription factor that is cleaved at the transmembrane domain by regulated intramembrane proteolysis in response to ER stress.
Hideo Iwamoto, Koji Matsuhisa, Atsushi Saito, Soshi Kanemoto, Rie Asada, Kenta Hino, Tomoko Takai, Min Cui, Xiang Cui, Masayuki Kaneko, Koji Arihiro, Kazuhiko Sugiyama, Kaoru Kurisu, Akio Matsubara, Kazunori Imaizumi   +14 more
doaj   +1 more source

Hedgehog Morphogens Act as Growth Factors Critical to Pre- and Postnatal Cardiac Development and Maturation: How Primary Cilia Mediate Their Signal Transduction

Cells, 2022
Primary cilia are crucial for normal cardiac organogenesis via the formation of cyto-architectural, anatomical, and physiological boundaries in the developing heart and outflow tract.
Lindsey A. Fitzsimons, Victoria L. Brewer, Kerry L. Tucker   +2 more
doaj   +1 more source

Hedgehog signaling in the liver

Journal of Hepatology, 2011
Reactivation of Hedgehog (Hh), a morphogenic signaling pathway that controls progenitor cell fate and tissue construction during embryogenesis occurs during many types of liver injury in adult. The net effects of activating the Hedgehog pathway include expansion of liver progenitor populations to promote liver regeneration, but also hepatic ...
Omenetti, Alessia, Choi, Steve, Michelotti, Gregory, Diehl, Anna Mae   +3 more
openaire   +2 more sources

Meningioma cells express primary cilia but do not transduce ciliary Hedgehog signals

Acta Neuropathologica Communications, 2020
Meningiomas are the most common primary intracranial tumors, but treatment options for meningioma patients are limited due to incomplete understanding of tumor biology.
Sarah Findakly, Abrar Choudhury, Vikas Daggubati, Melike Pekmezci, Ursula E. Lang, David R. Raleigh   +5 more
doaj   +1 more source

The Roles of Hedgehog Signaling Pathway in Radioresistance of Cervical Cancer

Dose-Response, 2019
Radiotherapy is an important treatment of cervical cancer, especially for advanced cervical cancer. According to research reports, Hedgehog signaling pathway plays an essential role in the growth, invasion, metastasis, recurrence, drug resistance, and ...
Chang Liu, Rensheng Wang
doaj   +1 more source

Hedgehog signaling in glioblastoma multiforme [PDF]

Cancer Biology & Therapy, 2012
Glioblastoma multiforme (GBM) is the most malignant brain tumor in adults with a median survival of 14.6 mo under the best available treatment. New treatment strategies are therefore urgently required, for which a profound understanding of tumor biology is necessary. Much effort has been devoted to tumor-specific aberrant signaling processes.
Braun, S, Oppermann, H, Mueller, A, Renner, C, Hovhannisyan, A, Baran-Schmidt, R, Gebhardt, R, Hipkiss, A, Thiery, J, Meixensberger, J, Gaunitz, F   +10 more
openaire   +3 more sources

Molecular Characterization of the Hedgehog Signaling Pathway and Its Necessary Function on Larval Myogenesis in the Pacific Oyster Crassostrea gigas

Frontiers in Physiology, 2018
Hedgehog signaling pathway participates in a chain of necessary physiological activities and dysregulation of the hedgehog signaling has been implicated in birth defects and diseases.
Huijuan Li, Qi Li, Qi Li, Hong Yu, Hong Yu   +4 more
doaj   +1 more source

Super-enhancer hijacking drives ectopic expression of hedgehog pathway ligands in meningiomas

Nature Communications, 2023
Hedgehog signaling mediates embryologic development of the central nervous system and other tissues and is frequently hijacked by neoplasia to facilitate uncontrolled cellular proliferation.
Mark W. Youngblood, Zeynep Erson-Omay, Chang Li, Hinda Najem, Süleyman Coșkun, Evgeniya Tyrtova, Julio D. Montejo, Danielle F. Miyagishima, Tanyeri Barak, Sayoko Nishimura, Akdes Serin Harmancı, Victoria E. Clark, Daniel Duran, Anita Huttner, Timuçin Avşar, Yasar Bayri, Johannes Schramm, Julien Boetto, Matthieu Peyre, Maximilien Riche, Roland Goldbrunner, Nduka Amankulor, Angeliki Louvi, Kaya Bilgüvar, M. Necmettin Pamir, Koray Özduman, Türker Kilic, James R. Knight, Matthias Simon, Craig Horbinski, Michel Kalamarides, Marco Timmer, Amy B. Heimberger, Ketu Mishra-Gorur, Jennifer Moliterno, Katsuhito Yasuno, Murat Günel   +36 more
doaj   +1 more source

Hedgehog Signaling as a Therapeutic Target for Airway Remodeling and Inflammation in Allergic Asthma

Cells, 2022
Genome-wide association studies (GWAS) have shown that variants of patched homolog 1 (PTCH1) are associated with lung function abnormalities in the general population.
Anthony Tam, Emmanuel Twumasi Osei, Chung Y. Cheung, Michael Hughes, Chen X. Yang, Kelly M. McNagny, Delbert R. Dorscheid, Gurpreet K. Singhera, Teal S. Hallstrand, Stephanie Warner, James C. Hogg, Tillie L. Hackett, Chinten J. Lim, Don D. Sin   +13 more
doaj   +1 more source

HHIPL2 positively governs Hedgehog signaling to accelerate non-small cell lung cancer progression via enhancing HNRNPC-mediated HNF1A mRNA stabilization

Cell Death and Disease
Sonic Hedgehog signaling is aberrantly activated in non-small cell lung cancer (NSCLC). However, the regulatory molecules of Sonic Hedgehog signaling during NSCLC development are still largely unknown. Here, we demonstrated that HHIP Like 2 (HHIPL2) is a
Ning Mu, Fanrong Liu, Xiangqing Song, Biao Wang, Yilin Zhu, Lingbing Li, Lingxiao Yang, Huacong Sui, Jinfu Wang, Fengyuan Gao, Yongjia Zhou, Yanfeng Lv, Zhongxian Tian, Peichao Li, Xiaogang Zhao   +14 more
doaj   +1 more source