Results 21 to 30 of about 58,670 (165)
The emerging roles of phosphatases in Hedgehog pathway
Cell Communication and Signaling, 2017 Hedgehog signaling is evolutionarily conserved and plays a pivotal role in cell fate determination, embryonic development, and tissue renewal. As aberrant Hedgehog signaling is tightly associated with a broad range of human diseases, its activities must ...
Long Zhao +4 more
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Cell Reports, 2017 Summary: Colon cancer is a heterogeneous tumor driven by a subpopulation of cancer stem cells (CSCs). To study CSCs in colon cancer, we used limiting dilution spheroid and serial xenotransplantation assays to functionally define the frequency of CSCs in ...
Joseph L. Regan +13 more
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Transducing the Hedgehog Signal [PDF]
Cell, 2000 Regardless of the status of Smo/Ptc associations, we now have to consider which, if any, of the newly found responses of Smo to Hh actually determine Smo signaling activity. As there really are no definitive data to guide us here, I will take the opportunity to discuss some possibilities.
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The presynaptic glycine transporter GlyT2 is regulated by the Hedgehog pathway in vitro and in vivo
Communications Biology, 2021 By modulating the activation state of the Hedgehog pathway, de la Rocha-Muñoz et al demonstrate that Hedgehog signaling controls the expression and transport activity of the neuronal glycine transporter GlyT2.
Andrés de la Rocha-Muñoz +8 more
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Journal of Experimental & Clinical Cancer Research, 2020 Background The mechanism underlying sorafenib resistance in hepatocellular carcinoma (HCC) remains unclear. Accumulating evidence suggests that tumor-initiating cells (TICs) are a pivotal driving force. Both CD44 and Hedgehog signaling play crucial roles
Siqi Wang +8 more
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Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling [PDF]
Nature Chemical Biology, 2013 Inhibition of Sonic hedgehog (Shh) signaling is of great clinical interest. Here we exploit Hedgehog acyltransferase (Hhat)-mediated Shh palmitoylation, a modification critical for Shh signaling, as a new target for Shh pathway inhibition. A target-oriented high-throughput screen was used to identify small-molecule inhibitors of Hhat.
Petrova, Elissaveta +4 more
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Hedgehog signaling in skin cancers [PDF]
Cellular Signalling, 2011 An increasing progress on the role of Hedgehog (Hh) signaling for carcinogenesis has been achieved since the link of Hh pathway to human cancer was firstly established. In particular, the critical role of Hh signaling in the development of Basal cell carcinoma (BCC) has been convincingly demonstrated by genetic mutation analyses, mouse models of BCCs ...
Chengxin, Li, Sumin, Chi, Jingwu, Xie
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Hedgehog inhibition promotes a switch from Type II to Type I cell death receptor signaling in cancer cells. [PDF]
PLoS ONE, 2011 TRAIL is a promising therapeutic agent for human malignancies. TRAIL often requires mitochondrial dysfunction, referred to as the Type II death receptor pathway, to promote cytotoxicity.
Satoshi Kurita +8 more
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Hedgehog signaling pathway as a potential target in the treatment of advanced gastric cancer
Tumor Biology, 2017 The sonic hedgehog signaling pathway is critical for cell proliferation, cell differentiation, and organ development during embryogenesis. Aberrant activation of the sonic hedgehog pathway has been associated with a variety of human cancers.
Dae-Hee Lee +2 more
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Hedgehog Signaling: An Achilles’ Heel in Cancer
Translational Oncology, 2019 Hedgehog signaling pathway originally identified in the fruit fly Drosophila is an evolutionarily conserved signaling mechanism with crucial roles in embryogenesis, growth and patterning. It exerts its biological effect through a signaling mechanism that
Madiha Niyaz +2 more
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