Results 21 to 30 of about 956,727 (289)

Hedgehog Signaling in Cortical Development [PDF]

, 2023
The Hedgehog (Hh) pathway plays a crucial role in embryonic development, acting both as a morphogenic signal that organizes tissue formation and a potent mitogenic signal driving cell proliferation.
Xuecai Ge, Cai, Eva, Ge, Xuecai, Maximiliano Gonzalez Barba, Barba, Maximiliano Gonzalez, Eva Cai   +5 more
core   +1 more source

Hedgehog signaling in cholangiocytes [PDF]

Current Opinion in Gastroenterology, 2011
Cells lining the biliary tree are targets of injury, but also orchestrate liver repair. The latter involves autocrine/paracrine signaling that enhances the viability and growth of residual ductular cells and promotes accumulation of inflammatory and myofibroblastic cells.
Alessia, Omenetti, Anna Mae, Diehl
openaire   +2 more sources

Effect of sonic hedgehog/β-TCP composites on bone healing within the critical-sized rat femoral defect [PDF]

, 2013
The creation of entirely synthetically derived bone substitute materials which are as effective as autologous bone grafts is desirable. Osteogenesis involves the concerted action of several proteins within a signaling cascade.
Henrich, Dirk, Marzi, Ingo, Seebach, Caroline, Flinspach, Armin Niklas, Wenger, Florian, Warzecha, Jörg   +5 more
core   +1 more source

Hedgehog Signaling and Steroidogenesis [PDF]

Annual Review of Physiology, 2015
Since its discovery nearly 30 years ago, the Hedgehog (Hh) signaling pathway has been shown to be pivotal in many developmental and pathophysiological processes in several steroidogenic tissues, including the testis, ovary, adrenal cortex, and placenta.
Isabella, Finco, Christopher R, LaPensee, Kenneth T, Krill, Gary D, Hammer   +3 more
openaire   +2 more sources

A novel protein encoded by circular SMO RNA is essential for Hedgehog signaling activation and glioblastoma tumorigenicity

Genome Biology, 2021
Background Aberrant activation of the Hedgehog pathway drives tumorigenesis of many cancers, including glioblastoma. However, the sensitization mechanism of the G protein-coupled-like receptor smoothened (SMO), a key component of Hedgehog signaling ...
Xujia Wu, Songhua Xiao, Maolei Zhang, Lixuan Yang, Jian Zhong, Bo Li, Fanying Li, Xin Xia, Xixi Li, Huangkai Zhou, Dawei Liu, Nunu Huang, Xuesong Yang, Feizhe Xiao, Nu Zhang   +14 more
doaj   +1 more source

Sonic hedgehog signaling: Alternative splicing and pathogenic role in medulloblastoma

Genes and Diseases, 2023
Alternative splicing (AS) produces the different mRNA splicing bodies, which are then translated into multiple protein isoforms and participate in various biological functions.
Meiyu Qu, Qiangqiang He, Jiahao Luo, Tingyu Shen, Ruibo Gao, Yana Xu, Chengyun Xu, Muhammad Qasim Barkat, Ling-Hui Zeng, Ximei Wu   +9 more
doaj   +1 more source

Gli1 mediates lung cancer cell proliferation and sonic hedgehog-dependent mesenchymal cell activation. [PDF]

, 2013
Non-Small-Cell-Lung-Cancer (NSCLC) represents approximately 85% of all lung cancers and remains poorly understood. While signaling pathways operative during organ development, including Sonic Hedgehog (Shh) and associated Gli transcription factors (Gli1 ...
Hennen, Elisabeth, Olga Bermudez, Oliver Eickelberg, Olga Bermudez (410727), Ina Koch (7903), Oliver Eickelberg (153848), Eickelberg, O., Bermudez, O., Koch, I., Lindner, Michael, Elisabeth Hennen, Hennen, E., Koch, Ina, Elisabeth Hennen (410728), Bermudez, Olga, Michael Lindner, Ina Koch, Michael Lindner (383308), Lindner, M., Eickelberg, Oliver, Koch Ina, Eickelberg Oliver, Bermudez Olga, Lindner Michael, Hennen Elisabeth   +24 more
core   +2 more sources

Noncanonical Hedgehog Signaling [PDF]

, 2012
The notion of noncanonical hedgehog (Hh) signaling in mammals has started to receive support from numerous observations. By noncanonical, we refer to all those cellular and tissue responses to any of the Hh isoforms that are independent of transcriptional changes mediated by the Gli family of transcription factors.
Donna, Brennan, Xiaole, Chen, Lan, Cheng, My, Mahoney, Natalia A, Riobo   +4 more
openaire   +2 more sources

The emerging roles of phosphatases in Hedgehog pathway

Cell Communication and Signaling, 2017
Hedgehog signaling is evolutionarily conserved and plays a pivotal role in cell fate determination, embryonic development, and tissue renewal. As aberrant Hedgehog signaling is tightly associated with a broad range of human diseases, its activities must ...
Long Zhao, Liguo Wang, Chunli Chi, Wenwen Lan, Ying Su   +4 more
doaj   +1 more source

Research progress on the mechanism of the Hedgehog signaling pathway during mandibular development [PDF]

口腔疾病防治
The source and process of mandible development are significantly different from those of other bones in the body, and abnormal development can lead to various bone-related diseases, seriously affecting the quality of life of patients.
XU Yao, LI Wenjin
doaj   +1 more source