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Hedgehog Signaling in Endochondral Ossification [PDF]
Journal of Developmental Biology, 2016 Hedgehog (Hh) signaling plays crucial roles in the patterning and morphogenesis of various organs within the bodies of vertebrates and insects. Endochondral ossification is one of the notable developmental events in which Hh signaling acts as a master regulator.
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Role of hedgehog signaling in the pathogenesis and therapy of heterotopic ossification
Frontiers in Cell and Developmental BiologyHeterotopic ossification (HO) is a pathological process that generates ectopic bone in soft tissues. Hedgehog signaling (Hh signaling) is a signaling pathway that plays an important role in embryonic development and involves three ligands: sonic hedgehog
Yiran Pei +7 more
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Mechanisms and therapeutic potential of the hedgehog signaling pathway in cancer
Cell Death DiscoveryA sort of major malignant disease, cancer can compromise human health wherever. Some mechanisms of the occurrence and evolution of cancer still seem elusive even now. Consequently, the therapeutic strategies for cancer must continually evolve.
Ge Cong +4 more
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Molecular Pain, 2017 Background Blood–nerve barrier disruption is pivotal in the development of neuroinflammation, peripheral sensitization, and neuropathic pain after peripheral nerve injury.
Nathan Moreau +7 more
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Hedgehog signaling contributes to bone cancer pain by regulating sensory neuron excitability in rats
Molecular Pain, 2018 Treating bone cancer pain continues to be a clinical challenge and underlying mechanisms of bone cancer pain remain elusive. Here, we reported that sonic hedgehog signaling plays a critical role in the development of bone cancer pain.
Su Liu +7 more
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Hedgehog: A Key Signaling in the Development of the Oligodendrocyte Lineage
Journal of Developmental Biology, 2016 The Hedgehog morphogen aroused an enormous interest since it was characterized as an essential signal for ventral patterning of the spinal cord two decades ago.
Elisabeth Traiffort +3 more
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A Hedgehog–Foxf axis coordinates dental follicle-derived alveolar bone formation
Nature CommunicationsThe alveolar bone is a specialized mineralized structure supporting the lifelong functionality of the tooth in mastication. The alveolar bone develops from the dental follicle (DF) during tooth root formation due to deliberate epithelial–mesenchymal ...
Mizuki Nagata +14 more
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Brain morphological analysis in mice with hyperactivation of the hedgehog signaling pathway
Frontiers in NeuroscienceHedgehog signaling is a highly conserved pathway that plays pivotal roles in morphogenesis, tumorigenesis, osteogenesis, and wound healing. Previous investigations in patients with Gorlin syndrome found low harm avoidance traits, and increased volumes in
Tadashi Shiohama +18 more
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