Results 41 to 50 of about 3,054 (263)
The emerging roles of phosphatases in Hedgehog pathway
Cell Communication and Signaling, 2017 Hedgehog signaling is evolutionarily conserved and plays a pivotal role in cell fate determination, embryonic development, and tissue renewal. As aberrant Hedgehog signaling is tightly associated with a broad range of human diseases, its activities must ...
Long Zhao +4 more
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Identification of a potent antagonist of smoothened in hedgehog signaling
Cell & Bioscience, 2021 Background Hedgehog signaling is essential to the regulation of embryonic development, tissue homeostasis, and stem cell self-renewal, making it a prime target for developing cancer therapeutics.
Junwan Fan +8 more
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Context-dependent ciliary regulation of hedgehog pathway repression in tissue morphogenesis.
PLoS Genetics, 2023 A fundamental problem in tissue morphogenesis is identifying how subcellular signaling regulates mesoscale organization of tissues. The primary cilium is a paradigmatic organelle for compartmentalized subcellular signaling.
Sun-Hee Hwang +4 more
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Palatogenesis: The role of Sonic hedgehog (Shh) signaling in the secondary palate development
Sakarya Tıp Dergisi, 2022 Palatogenesis is a complicated and precisely balanced process in which malfunctions induce congenital cleft palate, one of the most common embryonic developmental anomaly seen in newborns.
Elvan Şahin, Reem Al-towaitee
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Hedgehog Signaling and Embryonic Craniofacial Disorders
Journal of Developmental Biology, 2019 Since its initial discovery in a Drosophila mutagenesis screen, the Hedgehog pathway has been revealed to be instrumental in the proper development of the vertebrate face. Vertebrates possess three hedgehog paralogs: Sonic hedgehog (Shh), Indian hedgehog
John Abramyan
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Shifted from Wnt to Hedgehog Signaling Pathways [PDF]
Molecular Cell, 2005 Two papers in recent issue of Developmental Cell (Glise et al. 2005; Gorfinkiel et al. 2005) have shown that Shifted, a Drosophila ortholog of Wnt Inhibitory Factor (WIF), modulates the distribution of Hedgehog protein in the wing imaginal disc through a Wnt-independent mechanism.
Xinhua Lin, Chun Han
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Recent Advances in the Clinical Targeting of Hedgehog/GLI Signaling in Cancer
Cells, 2019 The Hedgehog/GLI signaling pathway plays an important role in normal embryonic tissue development and has been implicated in the pathogenesis of various human cancers.
Hao Xie +3 more
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Sonic hedgehog signalling pathway: a complex network [PDF]
Annals of Neurosciences, 2014 Sonic Hedgehog (Shh) signalling cascade is one of the intricate signal transduction mechanisms that govern the precisely regulated developmental processes of multicellular organisms. Along with establishing the patterns of cellular differentiation to direct complex organ formation, it also has an important role in post-embryonic tissue regeneration and
Fozia Zakaria +9 more
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Ethanol Effects on Early Developmental Stages Studied Using the Zebrafish
Biomedicines, 2022 Fetal alcohol spectrum disorder (FASD) results from prenatal ethanol exposure. The zebrafish (Danio rerio) is an outstanding in vivo FASD model. Early development produced the three germ layers and embryonic axes patterning.
Priyadharshini Manikandan +2 more
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Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source