Results 41 to 50 of about 51,121 (302)
Activation of the hedgehog pathway in advanced prostate cancer
Molecular Cancer, 2004 Background The hedgehog pathway plays a critical role in the development of prostate. However, the role of the hedgehog pathway in prostate cancer is not clear. Prostate cancer is the second most prevalent cause of cancer death in American men. Therefore,
McCormick Frank +8 more
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Maintenance of Taste Organs Is Strictly Dependent on Epithelial Hedgehog/GLI Signaling. [PDF]
PLoS Genetics, 2016 For homeostasis, lingual taste papilla organs require regulation of epithelial cell survival and renewal, with sustained innervation and stromal interactions.
Alexandre N Ermilov +7 more
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Identification of a potent antagonist of smoothened in hedgehog signaling
Cell & Bioscience, 2021 Background Hedgehog signaling is essential to the regulation of embryonic development, tissue homeostasis, and stem cell self-renewal, making it a prime target for developing cancer therapeutics.
Junwan Fan +8 more
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Lipid metabolism fattens up hedgehog signaling
BMC Biology, 2017 Signaling pathways direct organogenesis, often through concentration-dependent effects on cells. The hedgehog pathway enables cells to sense and respond to hedgehog ligands, of which the best studied is sonic hedgehog. Hedgehog signaling is essential for
Robert Blassberg, John Jacob
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Meningioma cells express primary cilia but do not transduce ciliary Hedgehog signals
Acta Neuropathologica Communications, 2020 Meningiomas are the most common primary intracranial tumors, but treatment options for meningioma patients are limited due to incomplete understanding of tumor biology.
Sarah Findakly +5 more
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Hedgehog Signaling Pathway and Autophagy in Cancer [PDF]
International Journal of Molecular Sciences, 2018 Hedgehog (Hh) pathway controls complex developmental processes in vertebrates. Abnormal activation of Hh pathway is responsible for tumorigenesis and maintenance of multiple cancers, and thus addressing this represents promising therapeutic opportunities. In recent years, two Hh inhibitors have been approved for basal cell carcinoma (BCC) treatment and
Zeng, X., Ju, D.
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The emerging roles of phosphatases in Hedgehog pathway
Cell Communication and Signaling, 2017 Hedgehog signaling is evolutionarily conserved and plays a pivotal role in cell fate determination, embryonic development, and tissue renewal. As aberrant Hedgehog signaling is tightly associated with a broad range of human diseases, its activities must ...
Long Zhao +4 more
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Hedgehog Signaling as a Therapeutic Target for Airway Remodeling and Inflammation in Allergic Asthma
Cells, 2022 Genome-wide association studies (GWAS) have shown that variants of patched homolog 1 (PTCH1) are associated with lung function abnormalities in the general population.
Anthony Tam +13 more
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Context-dependent ciliary regulation of hedgehog pathway repression in tissue morphogenesis.
PLoS Genetics, 2023 A fundamental problem in tissue morphogenesis is identifying how subcellular signaling regulates mesoscale organization of tissues. The primary cilium is a paradigmatic organelle for compartmentalized subcellular signaling.
Sun-Hee Hwang +4 more
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Drugging Hedgehog: signaling the pathway to translation [PDF]
BMC Biology, 2013 First discovered in Drosophila, the Hedgehog signaling pathway controls a wide range of developmental processes and is implicated in a variety of cancers. The success of a screen for chemical modulators of this pathway, published in 2002, opened a new chapter in the quest to translate the results of basic developmental biology research into therapeutic
Carney, Tom J, Ingham, Philip W
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