Results 1 to 10 of about 215,192 (350)
Biochemical Characterization of Middle East Respiratory Syndrome Coronavirus Helicase
mSphere, 2016 Middle East respiratory syndrome coronavirus (MERS-CoV) helicase is a superfamily 1 helicase containing seven conserved motifs. We have cloned, expressed, and purified a Strep-fused recombinant MERS-CoV nonstructural protein 13 (M-nsp13) helicase ...
Adeyemi O. Adedeji, Hilary Lazarus
doaj +2 more sources
Structural elucidation of Langat virus helicase unveils dual-target inhibition for broad-spectrum anti-flaviviruses strategy [PDF]
Frontiers in Cellular and Infection MicrobiologyIntroductionFlaviviruses, such as dengue, Zika, and Langat virus (LGTV), pose significant global health threats, highlighting the urgent need for broad-spectrum antiviral therapies.
Ruixue Li +4 more
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Structural basis of Zika virus helicase in recognizing its substrates
Protein & Cell, 2016 The recent explosive outbreak of Zika virus (ZIKV) infection has been reported in South and Central America and the Caribbean. Neonatal microcephaly associated with ZIKV infection has already caused a public health emergency of international concern.
Hongliang Tian +14 more
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The Impact of Next Generation Sequencing in Diagnosis and Management of Rare Diseases: Bloom Syndrome [PDF]
Modern Medicine, 2022 Bloom syndrome is an exceptionally rare autosomal recessive disorder characterized by a considerable genomic instability due to the defective DNA damage repair machine.
Ina-Ofelia FOCSA +6 more
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RAD51 bypasses the CMG helicase to promote replication fork reversal
Science, 2023 Replication fork reversal safeguards genome integrity as a replication stress response. DNA translocases and the RAD51 recombinase catalyze reversal. However, it remains unknown why RAD51 is required and what happens to the replication machinery during ...
Wenpeng Liu +6 more
semanticscholar +1 more source
Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase
Nature Communications, 2021 There is currently a lack of effective drugs to treat people infected with SARS-CoV-2, the cause of the global COVID-19 pandemic. The SARS-CoV-2 Non-structural protein 13 (NSP13) has been identified as a target for anti-virals due to its high sequence ...
J. Newman +12 more
semanticscholar +1 more source
BIO-PROTOCOL, 2014 Helicases are a class of enzymes which are motor proteins using energy derived from ATP hydrolysis to move directionally along a nucliec acid phosphodiester backbone (such as DNA, RNA and DNA-RNA hybrids) and separate two annealed nucleic acid strands. Many cellular processes, such as transcription, DNA replication, recombination and DNA repair involve
Xin Wang +3 more
openaire +3 more sources
eLife, 2021 The PcrA/UvrD helicase binds directly to RNA polymerase (RNAP) but the structural basis for this interaction and its functional significance have remained unclear.
Inigo Urrutia-Irazabal +4 more
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UPF1—From mRNA Degradation to Human Disorders
Cells, 2023 Up-frameshift protein 1 (UPF1) plays the role of a vital controller for transcripts, ready to react in the event of an incorrect translation mechanism.
Jacek Staszewski +4 more
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Frontiers in Immunology, 2022 We present evidence suggesting that the severe acute respiratory syndrome (SARS) coronavirus non-structural protein 13 (Nsp13) modulates the Z-RNA dependent regulated cell death pathways .
Alan Herbert +2 more
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