Results 21 to 30 of about 215,192 (350)

Duplex DNA from Sites of Helicase-Polymerase Uncoupling Links Non-B DNA Structure Formation to Replicative Stress [PDF]

, 2020
BACKGROUND: Replication impediments can produce helicase-polymerase uncoupling allowing lagging strand synthesis to continue for as much as 6 kb from the site of the impediment.
Abdelhamid, Mahmoud A S, Amparo, Camille, Bedell, Victoria, Clark, Jarrod, Martella, Marianna, Murata-Collins, Joyce L, Pichiorri, Flavia, Smith, Steven S, Waller, Zoë A E, Warner, Emily F   +9 more
core   +2 more sources

A conserved Mcm4 motif is required for Mcm2-7 double-hexamer formation and origin DNA unwinding

eLife, 2019
Licensing of eukaryotic origins of replication requires DNA loading of two copies of the Mcm2-7 replicative helicase to form a head-to-head double-hexamer, ensuring activated helicases depart the origin bidirectionally.
Kanokwan Champasa, Caitlin Blank, Larry J Friedman, Jeff Gelles, Stephen P Bell   +4 more
doaj   +1 more source

Identification of Five Putative Yeast RNA Helicase Genes [PDF]

, 1990
The RNA helicase gene family encodes a group of eight homologous proteins that share regions of sequence similarity. This group of evolutionarily conserved proteins presumably all utilize ATP (or some other nucleoside triphosphate) as an energy source ...
Abelson, John, Arenas, Jaime, Chang, Tien-Hsien   +2 more
core   +1 more source

Viral hijacking of a replicative helicase loader and its implications for helicase loading control and phage replication

eLife, 2016
Replisome assembly requires the loading of replicative hexameric helicases onto origins by AAA+ ATPases. How loader activity is appropriately controlled remains unclear.
Iris V Hood, James M Berger
doaj   +1 more source

Structural basis for DEAH-helicase activation by G-patch proteins

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance RNA helicases exert mechanical force that changes RNA configurations in many essential cellular pathways, e.g., during mRNA maturation or assembly of ribosomes.
M. Studer, L. Ivanović, Marco E. Weber, Sabrina Marti, S. Jonas   +4 more
semanticscholar   +1 more source

Helicase activity on DNA as a propagating front [PDF]

, 2003
We develop a propagating front analysis, in terms of a local probability of zipping, for the helicase activity of opening up a double stranded DNA (dsDNA).
Alberts B., Betterton M. D., Bhattacharjee S. M., Bhattacharjee S. M., Bhattacharjee S. M., Lohman T. M.   +5 more
core   +2 more sources

WRN Helicase is a Synthetic Lethal Target in Microsatellite Unstable Cancers

Nature, 2019
Synthetic lethality—an interaction between two genetic events through which the co-occurrence of these two genetic events leads to cell death, but each event alone does not—can be exploited for cancer therapeutics1.
Edmond M. Chan, T. Shibue, James M. McFarland, Benjamin Gaeta, M. Ghandi, N. Dumont, Alfredo Gonzalez, J. McPartlan, Tianxia Li, Yanxi Zhang, J. Liu, J. Lazaro, Peili Gu, C. Piett, Annie Apffel, Syed O Ali, Rebecca Deasy, P. Keskula, R. Ng, E. Roberts, E. Reznichenko, Lisa Leung, M. Alimova, M. Schenone, Mirazul Islam, Y. Maruvka, Yang Liu, Jatin Roper, Srivatsan Raghavan, M. Giannakis, Yuen-Yi Tseng, Z. Nagel, A. D’Andrea, D. Root, J. Boehm, G. Getz, Sandy Chang, T. Golub, Aviad Tsherniak, F. Vazquez, A. Bass   +40 more
semanticscholar   +1 more source

State-of-the-art tools unveil potent drug targets amongst clinically approved drugs to inhibit helicase in SARS-CoV-2

Archives of medical science : AMS, 2020
Introduction The extreme health and economic problems in the world due to the SARS-CoV-2 infection have led to an urgent need to identify potential drug targets for treating coronavirus disease 2019 (COVID-19).
J. Borgio, H. S. Alsuwat, Waad Mohammed Al Otaibi, Abdallah M. Ibrahim, N. Almandil, L. A. Al Asoom, M. Salahuddin, Balu Kamaraj, S. Abdulazeez   +8 more
semanticscholar   +1 more source

DNA Helicases

Cold Spring Harbor Symposia on Quantitative Biology, 1979
In summary, we postulate that DNA unwinding and ATP dephosphorylation are coupled in different ways, depending on whether the fibrous ATPase or one of the globular ATPases provides the catalytic agent. Unanswered is the question of whether there is stoichiometry of ATP utilization during the unwinding of a duplex, and unsolved is the role of the ...
Kuhn, B., Abdel-Monem, M., Hoffmann-Berling, H.   +2 more
openaire   +3 more sources

Structures of RecBCD in complex with phage-encoded inhibitor proteins reveal distinctive strategies for evasion of a bacterial immunity hub

eLife, 2022
Following infection of bacterial cells, bacteriophage modulate double-stranded DNA break repair pathways to protect themselves from host immunity systems and prioritise their own recombinases.
Martin Wilkinson, Oliver J Wilkinson, Connie Feyerherm, Emma E Fletcher, Dale B Wigley, Mark S Dillingham   +5 more
doaj   +1 more source