Results 31 to 40 of about 194,742 (384)
Frontiers in Microbiology, 2018 Chromosomal replication initiation requires dynamic mechanisms in higher-order nucleoprotein complexes that are constructed at the origin of replication.
Yukari Sakiyama +5 more
doaj +1 more source
DNA Helicase–Polymerase Coupling in Bacteriophage DNA Replication
Viruses, 2021 Bacteriophages have long been model systems to study the molecular mechanisms of DNA replication. During DNA replication, a DNA helicase and a DNA polymerase cooperatively unwind the parental DNA.
Chen-Yu Lo, Yang Gao
doaj +1 more source
Molecules, 2020 This short review is focused on enzymatic properties of human ATP-dependent RNA helicase DDX3 and the development of antiviral and anticancer drugs targeting cellular helicases.
M. Kukhanova, I. Karpenko, A. Ivanov
semanticscholar +1 more source
Eukaryotic DNA helicases [PDF]
FEBS Letters, 1990 DNA is very stable in its double‐stranded form. For many processes of DNA metabolism, such as replication, repair, recombination and transcription, the DNA has to be brought transiently into a single‐stranded form. DNA helicases are enzymes capable of melting the hydrogen bonds of base pairs by using the energy of nucleoside‐5'‐triphosphate hydrolysis.
Ulrich Hübscher, Pia Thömmes
openaire +3 more sources
Helicase activity on DNA as a propagating front [PDF]
, 2003 We develop a propagating front analysis, in terms of a local probability of zipping, for the helicase activity of opening up a double stranded DNA (dsDNA).
Alberts B. +5 more
core +2 more sources
WRN Helicase is a Synthetic Lethal Target in Microsatellite Unstable Cancers
Nature, 2019 Synthetic lethality—an interaction between two genetic events through which the co-occurrence of these two genetic events leads to cell death, but each event alone does not—can be exploited for cancer therapeutics1.
Edmond M. Chan +40 more
semanticscholar +1 more source
Nature Structural & Molecular Biology, 2006 Recent additions to the helicase family include motor proteins that do not actually unwind DNA, but rather translocate it. By sensing short polar sequences that orient the bacterial chromosome, the FtsK helicase translocates DNA so as to align the termini of replicated chromosomes with each other, facilitating the late stages of chromosome segregation.
Strick, Terence, Quessada-Vial, Audrey
openaire +3 more sources
Vaccines, 2021 In response to the ongoing COVID-19 pandemic, the global effort to develop high efficacy countermeasures to control the infection are being conducted at full swing.
Irfan A. Rather +6 more
doaj +1 more source
m6A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2
Nature Communications, 2019 Dynamic mRNA modification in the form of N6-methyladenosine (m6A) adds considerable richness and sophistication to gene regulation. The m6A mark is asymmetrically distributed along mature mRNAs, with approximately 35% of m6A residues located within the ...
Yuanhui Mao +6 more
semanticscholar +1 more source
The RNA helicase database [PDF]
Nucleic Acids Research, 2010 RNA helicases are ubiquitous and essential enzymes that function in nearly all aspects of RNA metabolism. The RNA helicase database (www.rnahelicase.org) integrates the wealth of accumulating information on RNA helicases in a readily accessible format.
Anja Jankowsky +2 more
openaire +3 more sources