Results 1 to 10 of about 452,289 (289)
Conformation of the Helix—Coil—Helix Polypeptide [PDF]
Polymer Journal, 1975 Semi-empirical energy calculations were performed to determine the conformation of the α-helix—random coil—α-helix polypeptide. The random-coil region includes only one amino acid residue in these calculations. The results are illustrated by conformational energy maps.
Nakata, Yoshiro, Suzuki, Keizo
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Helix-Helix Interactions: Is the Medium the Message? [PDF]
Structure, 2015 In this issue of Structure, Zhang and colleagues compare the helix-helix interaction spaces of an extensive database of soluble and membrane proteins. Intriguingly, the resultant clusters show similar helix interaction geometries between the protein classes, differing in detail only by patterns of local interactions and inter-helical distances.
Deber, Charles M., Ng, Derek P.
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Spare parts for helix–helix interaction [PDF]
Protein Engineering, Design and Selection, 1999 About 6000 contact regions (patches) of helix-to-helix packing from 300 well-resolved non-homologous protein structures were considered. The patches were defined by the spatial helical neighbors and were estimated in atomic detail using a variable distance criterion. The following questions are addressed.
R, Preissner, A, Goede, C, Frömmel
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Genome-wide rare variant analysis for thousands of phenotypes in over 70,000 exomes from two cohorts
Nature Communications, 2020 Population-based association analyses of rare genetic variants with complex traits are limited by the availability of data from sufficiently large cohorts. Here, Cirulli et al.
Elizabeth T. Cirulli +12 more
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Vaccines, 2022 At this present stage of COVID-19 re-emergence, designing an effective candidate vaccine for different variants of SARS-CoV-2 is a study worthy of consideration.
Elijah Kolawole Oladipo +14 more
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Helix is a helix is a helix? [PDF]
Proceedings of the National Academy of Sciences, 1997 The experimental approach has been to perform “host–guest” experiments in which the effect of individually substituting each “guest” amino acid on the stability of a “host” protein or peptide is measured. As a result of such studies, a quantitative ranking of the propensity of each amino acid to adopt a α-helical or β-sheet conformation is obtained (3,
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Protein Science, 1998 Abstract Helix‐capping motifs are specific patterns of hydrogen bonding and hydrophobic interactions found at or near the ends of helices in both proteins and peptides. In an α‐helix, the first four >N‐H groups and last four >C=O groups necessarily lack intrahelical hydrogen bonds.
R, Aurora, G D, Rose
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Frontiers in Immunology, 2017 Angiogenesis is the process of new blood vessel formation and is essential for a tumor to grow beyond a certain size. Tumors secrete the pro-angiogenic factor vascular endothelial growth factor, which acts upon local endothelial cells by binding to ...
Baomin Tian +4 more
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Development of a Highly Differentiated Human Primary Proximal Tubule MPS Model (aProximate MPS Flow)
Bioengineering, 2023 The kidney proximal tubule (PT) mediates renal drug elimination in vivo and is a major site of drug-induced toxicity. To reliably assess drug efficacy, it is crucial to construct a model in which PT functions are replicated.
Francesca Pisapia +4 more
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Helix-helix interactions in lipid bilayers
Biophysical Journal, 1996 Using a continuum model, we calculated the electrostatic interaction free energy between two alpha-helices in three environments: the aqueous phase, a low dielectric alkane phase, and a simple representation of a lipid bilayer. As was found in previous work, helix-helix interactions in the aqueous phase are quite weak, because of solvent screening, and
Ben-Tal, N., Honig, B.
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