Results 1 to 10 of about 136,346 (223)

Prediction of Antigenic Distance in Influenza A Using Attribute Network Embedding

Viruses, 2023
Owing to the rapid changes in the antigenicity of influenza viruses, it is difficult for humans to obtain lasting immunity through antiviral therapy. Hence, tracking the dynamic changes in the antigenicity of influenza viruses can provide a basis for ...
Fujun Peng, Yuanling Xia, Weihua Li
doaj   +1 more source

Gene transfer into hepatocytes using asialoglycoprotein receptor mediated endocytosis of DNA complexed with an artificial tetra-antennary galactose ligand [PDF]

, 1992
We have constructed an artificial ligand for the hepatocyte-specific asialoglycoprotein receptor for the purpose of generating a synthetic delivery system for DNA.
Ashwell G., Atherton E., Atherton E., Baenziger J. U., Christian Plank, Connolly D. T., Corley Cain C., Curiel D. T., DeWet J., Ellman G. L., Ernst Wagner, Gotten M., Gotten M., Gotten M., Huckett B., Karl Mechtler, Kempen H. J. M., Knowles B. B., Kurt Zatloukal, Lee Y. C., Matt Cotten, Orrantia E., Patek P.Q., Rosenkranz A. A., Seifter S., Severne Y., Spiess M., Tam J. P., Wagner E., Wagner E., Wagner E., Wagner E., Wharton S. A., Wu C., Wu G. Y., Zatloukal K., Zenke M.   +36 more
core   +1 more source

Mapping person-to-person variation in viral mutations that escape polyclonal serum targeting influenza hemagglutinin

eLife, 2019
A longstanding question is how influenza virus evolves to escape human immunity, which is polyclonal and can target many distinct epitopes. Here, we map how all amino-acid mutations to influenza’s major surface protein affect viral neutralization by ...
Juhye M Lee, Rachel Eguia, Seth J Zost, Saket Choudhary, Patrick C Wilson, Trevor Bedford, Terry Stevens-Ayers, Michael Boeckh, Aeron C Hurt, Seema S Lakdawala, Scott E Hensley, Jesse D Bloom   +11 more
doaj   +1 more source

Characterization of Hemagglutinin Gene Fragment of H9N2 Avian Influenza Virus Isolated from Environmental Live Bird Market in the Greater Jakarta Area

Tropical Animal Science Journal, 2022
Virus H9N2 has become the most common subtype of low pathogenic avian influenza (LPAI) in poultry and shows the ability to infect humans. One of the important factors triggering the virus ​​pandemic is the live bird market (LBM).
N. R. Maharani, H. Susetya, M. H. Wibowo
doaj   +1 more source

Quantitative prediction of multivalent ligand–receptor binding affinities for influenza, cholera, and anthrax inhibition [PDF]

, 2018
Multivalency achieves strong, yet reversible binding by the simultaneous formation of multiple weak bonds. It is a key interaction principle in biology and promising for the synthesis of high-affinity inhibitors of pathogens. We present a molecular model
Liese, Susanne, Netz, Roland R.
core   +2 more sources

Protein Palmitoylation and Its Role in Bacterial and Viral Infections

Frontiers in Immunology, 2018
S-palmitoylation is a reversible, enzymatic posttranslational modification of proteins in which palmitoyl chain is attached to a cysteine residue via a thioester linkage.
Justyna Sobocińska, Paula Roszczenko-Jasińska, Anna Ciesielska, Katarzyna Kwiatkowska   +3 more
doaj   +1 more source

Broccoli Leaves Attenuate Influenza A Virus Infection by Interfering With Hemagglutinin and Inhibiting Viral Attachment

Frontiers in Pharmacology, 2022
Broccoli (Brassica oleracea L. var. Italica) leaves are a byproduct of broccoli and could be used as a food source. The study aimed to evaluate the effect of broccoli leaves on influenza A virus (IAV) infection.
Won-Kyung Cho, Nam-Hui Yim, Myong-Min Lee, Chang-Hoon Han, Jin Yeul Ma   +4 more
doaj   +1 more source

The Porphyromonas gingivalis hemagglutinins HagB and HagC are major mediators of adhesion and biofilm formation [PDF]

, 2016
Porphyromonas gingivalis is a bacterium associated with chronic periodontitis that possesses a family of genes encoding hemagglutinins required for heme acquisition.
Connolly, E., Culshaw, S., Doyle, R., Millhouse, E., Moran, G.P., Ramage, G.   +5 more
core   +1 more source

Hemagglutinin Gene Clade 3C.2a Influenza A(H3N2) Viruses, Alachua County, Florida, USA, 2014–15

Emerging Infectious Diseases, 2016
Influenza A(H3N2) strains isolated during 2014–15 in Alachua County, Florida, USA, belonged to hemagglutinin gene clade 3C.2a. High rates of influenza-like illness and confirmed influenza cases in children were associated with a decrease in estimated ...
John Lednicky, Nicole M. Iovine, Joe Brew, Julia Loeb, Jonathan D. Sugimoto, Kenneth H. Rand, J. Glenn Morris   +6 more
doaj   +1 more source

Dual Detection of Hemagglutinin Proteins of H5N1 and H1N1 Influenza Viruses Based on FRET Combined With DNase I

Frontiers in Microbiology, 2022
Influenza A viruses (IAV) are classified based on their surface proteins hemagglutinin (HA) and neuraminidase (NA). Both pandemic H1N1 (pH1N1) and highly pathogenic avian influenza (HPAI) H5N1 viruses pose a significant threat to public health. Effective
Zhiyun Wang, Qiuzi Zhao, Mengqian Huang, Yuqin Duan, Feifei Li, Tao Wang   +5 more
doaj   +1 more source