Results 61 to 70 of about 16,332 (165)

Electrochemical Microarray as a Rapid Tool for Identification of Mutations in Influenza Virus Genes

International Journal of Electrochemical Science, 2015
Influenza viruses, as etiological agent of acute respiratory-related diseases, cause seasonal epidemics and/or less frequently pandemics with substantial mortality across the world.
Miguel-Angel Merlos Rodrigo, Ludmila Krejcova, Zbynek Heger, Ondrej Zitka, Vojtech Adam, Rene Kizek   +5 more
doaj   +1 more source

Modulation of B cell receptor activation by antibody competition

Cell Reports
Summary: During repeated virus exposure, pre-existing antibodies can mask viral epitopes by competing with B cell receptors for antigen. Although epitope masking has the potential to steer B cell responses away from conserved epitopes and toward those ...
Yuanyuan He, Zijian Guo, Michael D. Vahey   +2 more
doaj   +1 more source

Characterization of Immune Response towards Generation of Universal Anti-HA-Stalk Antibodies after Immunization of Broiler Hens with Triple H5N1/NA-HA-M1 VLPs

Viruses, 2022
(1) Background: Avian influenza viruses (AIVs) promptly evade preexisting immunity by constantly altering the immunodominant neutralizing antibody epitopes (antigenic drift) or by procuring new envelope serotypes (antigenic shift).
Beata Gromadzka, Milena Chraniuk, Lilit Hovhannisyan, Karolina Uranowska, Bogusław Szewczyk, Magdalena Narajczyk, Mirosława Panasiuk   +6 more
doaj   +1 more source

Applying Baculovirus Surface Display Technology for Influenza Cytokine Profiling, Serological Detection and Antiviral Screening

Microbial Biotechnology, Volume 19, Issue 6, June 2026.
By displaying the hemagglutinin (HA) or neuraminidase (NA) proteins of influenza viruses on the surface of baculoviruses and infected insect cells, a safe and flexible pseudovirus system capable of performing cytokine analysis, serological detection and antiviral drug screening is established.
Li‐Yun Cheng, Zheng Yu Phan, Chi‐Wei Wang, Ching‐Fen Shen, Ping‐Chung Kuo, Hao‐Ze Li, Yu‐Chan Chao, Chih‐Hsuan Tsai   +7 more
wiley   +1 more source

Association of Influenza Virus Proteins with Membrane Rafts

Advances in Virology, 2011
Assembly and budding of influenza virus proceeds in the viral budozone, a domain in the plasma membrane with characteristics of cholesterol/sphingolipid-rich membrane rafts.
Michael Veit, Bastian Thaa
doaj   +1 more source

Streamlined Synthesis and Structure–Activity Relationship Analysis of 2‐Amidothiophene‐3‐Carboxamides Targeting Influenza Polymerase PA‐PB1 Heterodimerization

ChemMedChem, Volume 21, Issue 10, 27 May 2026.
Development of a three‐step synthesis and replacement of the cycloheptyl moiety in cycloheptathiophene‐3‐carboxamide derivatives revealed how thiophene C‐5 substitutions modulate PA–PB1 inhibition, antiviral potency, and water solubility. The phenyl analog 9 delivered sub‐µM potency across multiple IV strains, while the methyl analog 5 achieved the ...
Tommaso Felicetti, Alessia Zago, Andrea Astolfi, Giuseppe Manfroni, Stefano Sabatini, Maria Letizia Barreca, Oriana Tabarrini, Arianna Loregian, Serena Massari   +8 more
wiley   +1 more source

Hijacking the Fusion Complex of Human Parainfluenza Virus as an Antiviral Strategy

mBio, 2020
The receptor binding protein of parainfluenza virus, hemagglutinin-neuraminidase (HN), is responsible for actively triggering the viral fusion protein (F) to undergo a conformational change leading to insertion into the target cell and fusion of the ...
T. C. Marcink, E. Yariv, K. Rybkina, V. Más, F. T. Bovier, A. des Georges, A. L. Greninger, C. A. Alabi, M. Porotto, N. Ben-Tal, A. Moscona   +10 more
doaj   +1 more source

Immunopotentiation by Natural Extracts: Mechanisms and Applications in Influenza Vaccine Adjuvant Development

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Natural Extracts as Candidate Influenza Vaccine Adjuvants. Seasonal influenza vaccines face limitations due to viral mutations and low efficacy in vulnerable populations. Traditional adjuvants often have safety or immune‐activation constraints, leading to increased interest in natural extracts from plants, marine organisms, and fungi.
Thi Len Ho, Eun‐Ju Ko
wiley   +1 more source

The heterologous expression of novel recombinant protein composed of HN and F moieties of Newcastle disease virus and immunogenicity evaluation in mouse model

Iranian Journal of Microbiology
Background and Objectives: The rapid spread of Newcastle disease (ND), driven by extensive commercial exchange in the poultry industry, necessitates urgent preventive measures.
Atena Mozafari, Mehregan Rahmani, Yasaman Yasini Nasab, Shahla Shahsavandi, Mahyat Jafari, Ali Hatef Salmanian   +5 more
doaj   +1 more source

Small Molecule Inhibition of Mononegavirales RNA Polymerases

Journal of Medical Virology, Volume 98, Issue 5, May 2026.
ABSTRACT The order Mononegavirales includes several non‐segmented negative‐sense RNA viruses that are significant human pathogens, whose transcription and replication depend on multifunctional RNA‐dependent RNA polymerase (L protein). Recent discoveries in cryo‐electron microscopy (cryo‐EM) have elucidated the structures of these polymerases and their ...
Claire R. Cao, Meer Mohammed, Ge Yang, Dong Wang   +3 more
wiley   +1 more source