Results 21 to 30 of about 147,872 (284)

The Role of Pili Protein 38,6 kDa Klebsiella pneumoniae as a Hemagglutinin and Adhesin Protein which Serves as a Virulence Factor

Journal of Agromedicine and Medical Sciences (AMS), 2019
Klebsiella pneumoniae is an infectious bacteria in various parts of the body. The presence of proteins in pili that will bind to cell surface receptors (adhesin proteins) and cell membrane sugar molecules (hemagglutinin proteins) is a very influential ...
Regina Finka, Dini Agustina, Dwita Aryadina Rachmawati, Enny Suswati, Diana Chusna Mufida, Ali Shodikin   +5 more
doaj   +1 more source

Novel β-Cyclodextrin-Based Heptavalent Glycyrrhetinic Acid Conjugates: Synthesis, Characterization, and Anti-Influenza Activity

Frontiers in Chemistry, 2022
In our continuing efforts toward the design of novel pentacyclic triterpene derivatives as potential anti-influenza virus entry inhibitors, a series of homogeneous heptavalent glycyrrhetinic acid derivatives based on β-cyclodextrin scaffold were designed
Shuobin Liang, Xinyuan Ma, Man Li, Yanliang Yi, Qianqian Gao, Yongmin Zhang, Lihe Zhang, Demin Zhou, Demin Zhou, Demin Zhou, Sulong Xiao   +10 more
doaj   +1 more source

Inferring stabilizing mutations from protein phylogenies : application to influenza hemagglutinin [PDF]

, 2009
One selection pressure shaping sequence evolution is the requirement that a protein fold with sufficient stability to perform its biological functions.
A Akasako, A Akasako, A Cao, A Martin, A Mitraki, A Rambaut, AA Pakula, AR Dinner, AR Fersht, AR Fersht, AS Yang, AS Yang, AV Gribenko, B Steipe, B Steipe, BM Broome, C Pal, C Park, CB Anfinsen, CB Do, CM Dobson, CT Saunders, D Gilis, D Perl, D Shortle, DA Cowan, DA Drummond, DA Drummond, DD Loeb, DM Taverna, DM Taverna, E Capriotti, E Hoffmann, E van Nimwegen, EPC Rocha, Eugene I. Shakhnovich, F Chiti, F Ronquist, G Parisi, GG Brownlee, H Akashi, H Li, H Schindelin, H Zhao, H Zhou, HW Hellinga, I Keller, IE Sanchez, IMP del Pino, J Felsenstein, J Felsenstein, J Felsenstein, J Felsenstein, J Kyte, JA Wells, JB Garrett, JD Bloom, JD Bloom, JD Bloom, JD Bloom, Jesse D. Bloom, JL Thorne, JM Koshi, JP Huelsenbeck, JP Huelsenbeck, JR Cochran, JR Lepock, JV Chamary, K Ishikawa, K Ishikawa, K Katayanagi, KA Bava, KA Gray, KB Zeldovich, KJ Szretter, KL Maxwell, L Giver, L Serrano, M Dai, M Haruki, M Jacob, M Lehmann, M Matrosovich, M Ueda, M Wunderlich, Matthew J. Glassman, MD Kumar, MF Sippl, MM Garcia-Mira, MM Gromiha, MP Canadillas, MS Fornasari, MW Pantoliano, N Amin, N Goldman, N Goldman, N Lartillot, N Tong, R Godoy-Ruiz, R Godoy-Ruiz, R Godoy-Ruiz, R Guerois, R Rabadan, R Sakaue, RC Edgar, RJ Ellis, S Govindarajan, S Kimura, S Kimura, S Nakajima, S Sato, SC Choi, SH White, SJ Gamblin, SS Jaswal, U Bastolla, V Parthiban, VG Dugan, VN Uversky, W Besenmatter, WS Sandberg, WSW Wong, XJ Zhang, Y Bao, YY Tseng, Z Chen   +125 more
core   +3 more sources

Gluing up hemagglutinin [PDF]

Science, 2017
Influenza The morbidity and economic tolls of influenza virus are huge, regardless of its capacity to kill. Vaccines and therapies to control this persistent threat are limited. In structural studies, Kadam and Wilson show how the broad-spectrum antiviral arbidol inactivates viral hemagglutinin (HA).
openaire   +2 more sources

Novel Platforms for the Development of a Universal Influenza Vaccine

Frontiers in Immunology, 2018
Despite advancements in immunotherapeutic approaches, influenza continues to cause severe illness, particularly among immunocompromised individuals, young children, and elderly adults.
Arun Kumar, Arun Kumar, Trine Sundebo Meldgaard, Trine Sundebo Meldgaard, Sylvie Bertholet, Sylvie Bertholet   +5 more
doaj   +1 more source

Five Unique Amino Acid Residues of Hemagglutinin (HA) Proteins of Swine Influenza A (H1N1) Detected in 2009 in Jakarta, Indonesia

Microbiology Indonesia, 2012
Nine HA genes of influenza A (H1N1) viruses originating from swine which were detected in 2009 in Jakarta, Indonesia, were characterized in this study. Nasopharyngeal and/or pharyngeal samples were extracted to obtain viral RNA genomes.
ANDI YASMON, YULIANTY MUHAYAR, VIVI SETIAWATY, BETI ERNAWATI DEWI, BUDIMAN BELA, FERA IBRAHIM   +5 more
doaj   +1 more source

Neutralizing Antibodies Targeting the Conserved Stem Region of Influenza Hemagglutinin

Vaccines, 2020
Influenza continues to be a public health threat despite the availability of annual vaccines. While vaccines are generally effective at inducing strain-specific immunity, they are sub-optimal or ineffective when drifted or novel pandemic strains arise ...
Sabari Nath Neerukonda, Russell Vassell, Carol D. Weiss   +2 more
doaj   +1 more source

Marked Rise in Replikin Counts in H5N1 Influenza Virus Localized to Lethality Gene p B1. [PDF]

, 2011
: Virus outbreaks have been found to be related to the concentration of a new class of genomic peptides, Replikins^1^. The eight genes of H5N1 influenza virus were analyzed for the distribution of Replikin Counts (number Replikins /100 amino acids) in 2 ...
Elenore S. Bogoch, Samuel Bogoch
core   +2 more sources

Characterization of H5N1 influenza A virus that caused the first highly pathogenic avian influenza outbreak in Saudi Arabia

Journal of Infection in Developing Countries, 2015
Introduction: Saudi Arabia (SA) experienced a highly pathogenic avian influenza (HPAI) H5N1 outbreak in domesticated birds in 2007. Methodology: Forty-three hemagglutinin (HA) and 41 neuraminidase (NA) genes of HPAI H5N1 viruses were sequenced and ...
Ahmed Ali Al-Qahtani, Muhammad Mubin, Fahad N. Almajhdi, Saud Alarifi, Damian M. dela Cruz, Muhammad Shah Nawaz ul Rehman, Mahmoud Moussa Ismail, Nisar Ahmed, Mohamed H. Al-Blowi, Hanif Khalak, Mohammed N. Al-Ahdal   +10 more
doaj   +1 more source

Quantitative prediction of multivalent ligand–receptor binding affinities for influenza, cholera, and anthrax inhibition [PDF]

, 2018
Multivalency achieves strong, yet reversible binding by the simultaneous formation of multiple weak bonds. It is a key interaction principle in biology and promising for the synthesis of high-affinity inhibitors of pathogens. We present a molecular model
Liese, Susanne, Netz, Roland R.
core   +2 more sources