Results 21 to 30 of about 13,620 (172)

Legume Lectins with Different Specificities as Potential Glycan Probes for Pathogenic Enveloped Viruses

Cells, 2022
Pathogenic enveloped viruses are covered with a glycan shield that provides a dual function: the glycan structures contribute to virus protection as well as host cell recognition.
Annick Barre, Els J. M. Van Damme, Bernard Klonjkowski, Mathias Simplicien, Jan Sudor, Hervé Benoist, Pierre Rougé   +6 more
doaj   +1 more source

A Live-Attenuated Prime, Inactivated Boost Vaccination Strategy with Chimeric Hemagglutinin-Based Universal Influenza Virus Vaccines Provides Protection in Ferrets: A Confirmatory Study

Vaccines, 2018
Influenza viruses cause severe diseases and mortality in humans on an annual basis. The current influenza virus vaccines can confer protection when they are well-matched with the circulating strains.
Raffael Nachbagauer, Florian Krammer, Randy A. Albrecht   +2 more
doaj   +1 more source

Generation of an Attenuated Chimeric Bat Influenza A Virus Live-Vaccine Prototype

Microbiology Spectrum, 2022
Recurring epizootic influenza A virus (IAV) infections in domestic livestock such as swine and poultry are associated with a substantial economic burden and pose a constant threat to human health.
Wei Ran, Jacob Schön, Kevin Ciminski, Julian Kraft, Susanne Kessler, Sophie Euchner, Donata Hoffmann, Anne Pohlmann, Martin Beer, Martin Schwemmle, Sebastian Giese   +10 more
doaj   +1 more source

Properties of an Antigenic Glycoprotein Isolated from Influenza Virus Hemagglutinin [PDF]

Journal of Virology, 1973
A purified antigen, HABA protein, has been derived from influenza virus concentrates by extraction with denaturing solvents. The protein lacks hemagglutinating activity but binds completely strain-specific, hemagglutination-inhibiting antibodies and induces neutralizing antibodies in experimental animals.
openaire   +2 more sources

A Viable Recombinant Rhabdovirus Lacking Its Glycoprotein Gene and Expressing Influenza Virus Hemagglutinin and Neuraminidase Is a Potent Influenza Vaccine [PDF]

Journal of Virology, 2015
ABSTRACT The emergence of novel influenza viruses that cause devastating human disease is an ongoing threat and serves as an impetus for the continued development of novel approaches to influenza vaccines. Influenza vaccine development has traditionally focused on producing humoral and/or cell-mediated immunity, often against the
Alex B, Ryder, Linda, Buonocore, Leatrice, Vogel, Raffael, Nachbagauer, Florian, Krammer, John K, Rose   +5 more
openaire   +2 more sources

Mechanisms of the action of povidone-iodine against human and avian influenza A viruses: its effects on hemagglutination and sialidase activities

Virology Journal, 2009
Background Influenza virus infection causes significant morbidity and mortality and has marked social and economic impacts throughout the world. The influenza surface glycoproteins, hemagglutinin (HA) and neuraminidase (NA), act cooperatively to support ...
Suzuki Takashi, Takahashi Tadanobu, Hiramatsu Hiroaki, Wilairat Prapon, Sriwilaijaroen Nongluk, Ito Morihiro, Ito Yasuhiko, Tashiro Masato, Suzuki Yasuo   +8 more
doaj   +1 more source

Possible repurposing of seasonal influenza vaccine for prevention of Zika virus infection [version 2; referees: 2 approved]

F1000Research, 2016
The in silico analysis shows that the envelope glycoproteins E of Zika viruses (ZIKV) isolated in Asia, Africa and South and Central America encode highly conserved information determining their interacting profile and immunological properties ...
Veljko Veljkovic, Slobodan Paessler
doaj   +1 more source

Rescue of a H3N2 influenza virus containing a deficient neuraminidase protein by a hemagglutinin with a low receptor-binding affinity.

PLoS ONE, 2012
Influenza viruses possess at their surface two glycoproteins, the hemagglutinin and the neuraminidase, of which the antagonistic functions have to be well balanced for the virus to grow efficiently. Ferraris et al.
Mathilde Richard, Alexandra Erny, Bertrand Caré, Aurélien Traversier, Mendy Barthélémy, Alan Hay, Yi Pu Lin, Olivier Ferraris, Bruno Lina   +8 more
doaj   +1 more source

Next-Generation Influenza HA Immunogens and Adjuvants in Pursuit of a Broadly Protective Vaccine

Viruses, 2021
Influenza virus, a highly mutable respiratory pathogen, causes significant disease nearly every year. Current vaccines are designed to protect against circulating influenza strains of a given season.
Kaito A. Nagashima, Jarrod J. Mousa
doaj   +1 more source

Single-dose mucosal immunization with a candidate universal influenza vaccine provides rapid protection from virulent H5N1, H3N2 and H1N1 viruses. [PDF]

PLoS ONE, 2010
The sudden emergence of novel influenza viruses is a global public health concern. Conventional influenza vaccines targeting the highly variable surface glycoproteins hemagglutinin and neuraminidase must antigenically match the emerging strain to be ...
Graeme E Price, Mark R Soboleski, Chia-Yun Lo, Julia A Misplon, Mary R Quirion, Katherine V Houser, Melissa B Pearce, Claudia Pappas, Terrence M Tumpey, Suzanne L Epstein   +9 more
doaj   +1 more source