Mucosal vaccination with recombinant adenovirus encoding nucleoprotein provides potent protection against influenza virus infection. [PDF]
PLoS ONE, 2013 Influenza vaccines that target the highly variable surface glycoproteins hemagglutinin and neuraminidase cause inconvenience of having vaccination every year.
So-Hee Kim +5 more
doaj +1 more source
SERINC5 restricts influenza virus infectivity.
PLoS Pathogens, 2022 SERINC5 is a multi-span transmembrane protein that is incorporated into HIV-1 particles in producing cells and inhibits HIV-1 entry. Multiple retroviruses like HIV-1, equine infectious anemia virus and murine leukemia virus are subject to SERINC5 ...
Fei Zhao +14 more
doaj +1 more source
Characterization of potent fusion inhibitors of influenza virus. [PDF]
PLoS ONE, 2015 New inhibitors of influenza viruses are needed to combat the potential emergence of novel human influenza viruses. We have identified a class of small molecules that inhibit replication of influenza virus at picomolar concentrations in plaque reduction ...
Michael Rowse +8 more
doaj +1 more source
Cleavage of hemagglutinin-bearing lentiviral pseudotypes and their use in the study of influenza virus persistence. [PDF]
PLoS ONE, 2014 Influenza A viruses (IAVs) are a major cause of infectious respiratory human diseases and their transmission is dependent upon the environment. However, the role of environmental factors on IAV survival outside the host still raises many questions.
Olivier Sawoo +5 more
doaj +1 more source
Cells, 2022 Pathogenic enveloped viruses are covered with a glycan shield that provides a dual function: the glycan structures contribute to virus protection as well as host cell recognition.
Annick Barre +6 more
doaj +1 more source
Alterations of membrane curvature during influenza virus budding [PDF]
, 2014 Influenza A virus belongs to the Orthomyxoviridae family. It is an enveloped virus that contains a segmented and negative-sense RNA genome. Influenza A viruses cause annual epidemics and occasional major pandemics, are a major cause of morbidity and ...
Agnieszka Martyna +29 more
core +1 more source
The Hemagglutinin-Esterase Fusion Glycoprotein Is a Primary Determinant of the Exceptional Thermal and Acid Stability of Influenza D Virus [PDF]
mSphere, 2017 Influenza D virus (IDV) utilizes cattle as a primary reservoir. Increased outbreaks in pigs and serological evidence of human infection have raised a concern about the potential of IDV adapting to humans. Here, we directly compared IDV’s stability to that of other influenza types (A, B, and C) following prolonged incubation at high temperatures or in a
Jieshi Yu +6 more
openaire +4 more sources
Generation of an Attenuated Chimeric Bat Influenza A Virus Live-Vaccine Prototype
Microbiology Spectrum, 2022 Recurring epizootic influenza A virus (IAV) infections in domestic livestock such as swine and poultry are associated with a substantial economic burden and pose a constant threat to human health.
Wei Ran +10 more
doaj +1 more source
Influenza Virus Hemagglutinin Glycoproteins with Different N-Glycan Patterns Activate Dendritic Cells In Vitro [PDF]
Journal of Virology, 2016 ABSTRACT Influenza virus hemagglutinin (HA) N-glycans play important regulatory roles in the control of virus virulence, antigenicity, receptor-binding specificity, and viral escape from the immune response. Considered essential for controlling innate and adaptive immune responses against influenza virus infections, dendritic ...
Michael Butler +5 more
openaire +3 more sources
Vaccines, 2018 Influenza viruses cause severe diseases and mortality in humans on an annual basis. The current influenza virus vaccines can confer protection when they are well-matched with the circulating strains.
Raffael Nachbagauer +2 more
doaj +1 more source