Results 41 to 50 of about 6,670 (185)

Cross-protection between antigenically distinct H1N1 swine influenza viruses from Europe and North America [PDF]

, 2011
Background An avian-like H1N1 swine influenza virus (SIV) is enzootic in swine populations of Western Europe. The virus is antigenically distinct from H1N1 SIVs in North America that have a classical swine virus-lineage H1 hemagglutinin, as does the ...
Brookes, Brown, Brown, Brown, Brownlee, Dürrwald, Garten, Grebe, Guan, Hinshaw, Hofshagen, Itoh, Kingsford, Kyriakis, Lange, Maurer-Stroh, Miller, Olsen, Olsen, Pensaert, Reed, Sandbulte, Scholtissek, Smith, Takemae, Van Reeth, Van Reeth, Van Reeth, Van Reeth, Van Reeth, Weingartl   +30 more
core   +1 more source

Cytotoxic polyfunctionality maturation of cytomegalovirus-pp65-specific CD4 + and CD8 + T-cell responses in older adults positively correlates with response size [PDF]

, 2016
Cytomegalovirus (CMV) infection is one of the most common persistent viral infections in humans worldwide and is epidemiologically associated with many adverse health consequences during aging.
A Harari, A Lelic, AM Simanek, AR Hersperger, AW Sylwester, C Courivaud, C Riou, E Derhovanessian, E Gimenez, E Sinclair, EJ Wherry, ET Roberts, F Bihl, F Kern, F Sallusto, G Makedonas, G Makedonas, G Pawelec, G Pawelec, GC Wang, GC Wang, IG Rodrigue-Gervais, J Cheng, J van Zanten, JM Fletcher, L Cicin-Sain, L Cicin-Sain, L Krol, ML Pita-Lopez, MR Betts, MR Wills, N Khan, P Trzonkowski, PA Darrah, Q Ouyang, R Lachmann, R Solana, R Vescovini, RA Seder, RA van Lier, S Cantisan, SA Migueles, SH Park, SR Hadrup, T Crough, V Appay, YL Chiu, YN Ji   +47 more
core   +1 more source

Non-Steroidal Estrogens Inhibit Influenza Virus by Interacting with Hemagglutinin and Preventing Viral Fusion

International Journal of Molecular Sciences, 2023
Influenza virus is one of the main causes of respiratory infections worldwide. Despite the availability of seasonal vaccines and antivirals, influenza virus infections cause an important health and economic burden. Therefore, the need to identify alternative antiviral strategies persists.
Franzi, Elisa, Mathez, Gregory, Dinant, Soraya, Deloizy, Charlotte, Kaiser, Laurent, Tapparel, Caroline, Le Goffic, Ronan, Cagno, Valeria   +7 more
openaire   +3 more sources

Genome-wide analyses reveal a highly conserved Dengue virus envelope peptide which is critical for virus viability and antigenic in humans. [PDF]

, 2016
Targeting regions of proteins that show a high degree of structural conservation has been proposed as a method of developing immunotherapies and vaccines that may bypass the wide genetic variability of RNA viruses.
Bordignon, Juliano, Dos Santos, Paula F, Ferguson, Brian J, Fleith, Renata C, Lo Sarzi, Maria, Lobo, Francisco P, Mansur, Daniel S, Patricio, Daniel O, Pavanelli, Wander R, Rocha, Mariana M, Santos, Claudia ND, Strottmann, Daisy M   +11 more
core   +1 more source

Reconstruction of the 1918 Influenza Virus: Unexpected Rewards from the Past [PDF]

, 2012
The influenza pandemic of 1918–1919 killed approximately 50 million people. The unusually severe morbidity and mortality associated with the pandemic spurred physicians and scientists to isolate the etiologic agent, but the virus was not isolated in 1918.
Ballinger, Centers for Disease Control and Prevention, Dunham, Easterbrook, Ekiert, Fleishman, Francis, Garten, Herfst, Imai, Jagger, Jain, Johnson, Kash, Kobasa, Kobasa, Kuiken, Mehle, Mehle, Memoli, Morens, Morens, Morens, Nabel, Nakamura, Obenauer, Pappas, Pearce, Qi, Qi, Rabadan, Rambaut, Reid, Russell, Sheng, Smith, Stevens, Stevens, Stevens, Tan, Taubenberger, Taubenberger, Taubenberger, Taubenberger, Taubenberger, Tumpey, Tumpey, Van Hoeven, Watanabe, Xu, Yu   +50 more
core   +3 more sources

The use of equine influenza pseudotypes for serological screening [PDF]

, 2012
Standard assays used for influenza serology present certain practical issues, such as inter-laboratory variability, complex protocols and the necessity for handling certain virus strains in high biological containment facilities.
Böttcher-Friebertshäuser, Eva, Daly, Janet, Ferrara, Francesca, Molesti, Eleonora, Scott, Simon, Temperton, Nigel   +5 more
core   +4 more sources

A Homogenous Fluorescence Quenching Based Assay for Specific and Sensitive Detection of Influenza Virus A Hemagglutinin Antigen

Sensors, 2015
Influenza pandemics cause millions of deaths worldwide. Effective surveillance is required to prevent their spread and facilitate the development of appropriate vaccines.
Longyan Chen, Suresh Neethirajan
doaj   +1 more source

Genetic characterization of influenza A(H3N2) viruses circulating in coastal Kenya, 2009-2017 [PDF]

, 2020
Background Influenza viruses evolve rapidly and undergo immune driven selection, especially in the hemagglutinin (HA) protein. We report amino acid changes affecting antigenic epitopes and receptor‐binding sites of A(H3N2) viruses circulating in Kilifi,
Agoti, Charles N., Chaves, Sandra S., Ngoi, Joyce M., Nokes, D. James, Nyasimi, Festus M., Nyiro, Joyce U., Otieno, Grieven P., Otieno, James R., Owuor, D. Collins   +8 more
core   +1 more source

Hemagglutinin Spatial Distribution Shifts in Response to Cholesterol in the Influenza Viral Envelope [PDF]

Biophysical Journal, 2015
Influenza virus delivers its genome to the host cytoplasm via a process of membrane fusion mediated by the viral hemagglutinin protein. Optimal fusion likely requires multiple hemagglutinin trimers, so the spatial distribution of hemagglutinin on the viral envelope may influence fusion mechanism.
Domanska, Marta K., Dunning, Rebecca A., Dryden, Kelly A., Zawada, Katarzyna E., Yeager, Mark, Kasson, Peter M.   +5 more
openaire   +2 more sources

A Live-Attenuated Prime, Inactivated Boost Vaccination Strategy with Chimeric Hemagglutinin-Based Universal Influenza Virus Vaccines Provides Protection in Ferrets: A Confirmatory Study

Vaccines, 2018
Influenza viruses cause severe diseases and mortality in humans on an annual basis. The current influenza virus vaccines can confer protection when they are well-matched with the circulating strains.
Raffael Nachbagauer, Florian Krammer, Randy A. Albrecht   +2 more
doaj   +1 more source