Results 71 to 80 of about 6,670 (185)

The Hemagglutinin of Influenza A Virus Induces Ferroptosis to Facilitate Viral Replication

Advanced Science
AbstractFerroptosis is a novel form of cell death caused by the accumulation of lipid peroxides in an iron‐dependent manner. However, the precise mechanism underlying the exploitation of ferroptosis by influenza A viruses (IAV) remains unclear. The results demonstrate that IAV promotes its own replication through ferritinophagy by sensitizing cells to ...
Aotian Ouyang, Tong Chen, Yi Feng, Jiahui Zou, Shaoyu Tu, Meijun Jiang, Huimin Sun, Hongbo Zhou   +7 more
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Lectins and Tetrahymena – A review [PDF]

, 2016
The unicellular ciliate Tetrahymena is a complete organism, one of the most highly developed protozoans, which has specialized organelles performing each of the functions characteristic to the cells of higher ranked animals.
Csaba, György
core   +1 more source

Inhibition of Influenza A Virus (H1N1) Fusion by Benzenesulfonamide Derivatives Targeting Viral Hemagglutinin

PLoS ONE, 2011
Hemagglutinin (HA) of the influenza virus plays a crucial role in the early stage of the viral life cycle by binding to sialic acid on the surface of host epithelial cells and mediating fusion between virus envelope and endosome membrane for the release of viral genomes into the cytoplasm.
Lei Zhu, Yuhuan Li, Shaohua Li, Haodong Li, Zongxing Qiu, Chichang Lee, Henry Lu, Xianfeng Lin, Rong Zhao, Li Chen, Jim Z Wu, Guozhi Tang, Wengang Yang   +12 more
openaire   +4 more sources

Structural Analysis of the Evolutionary Origins of Influenza Virus Hemagglutinin and Other Viral Lectins [PDF]

Journal of Virology, 2013
ABSTRACT Influenza virus and other viruses use host cell surface sugars as receptors. Here we show that the sugar-binding domains in influenza virus hemagglutinin and other viral lectins share the same structural fold as human galectins (host lectins).
Lang, Chen, Fang, Li
openaire   +2 more sources

Glycomics-based analysis of chicken red blood cells provides insight into the selectivity of the viral agglutination assay [PDF]

, 2011
Agglutination of red blood cells (RBCs), including chicken RBCs (cRBCs), has been used extensively to estimate viral titer, to screen glycan-receptor binding preference, and to assess the protective response of vaccines.
Amano, Boon, Chandrasekaran, Connor, Di Patrizi, Di Patrizi, Dorland, Dorland, Duk, Fournet, Gamblin, Green, Guile, Halbeek, Ito, Killian, Koles, Leeflang, Lu, Maines, Mechref, Medeiros, Nobusawa, Rogers, Shriver, Song, Srinivasan, Stevens, Strecker, Tretter, Uchida, Viswanathan, Zaia, Zaikin, Zhang   +34 more
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Antigenic mapping of an H9N2 avian influenza virus reveals two discrete antigenic sites and a novel mechanism of immune escape [PDF]

, 2015
H9N2 avian influenza virus is a major cause of poultry production loss across Asia leading to the wide use of vaccines. Efficacy of vaccines is often compromised due to the rapid emergence of antigenic variants.
Adamiak, B, Barclay, W, Iqbal, M, James, J, Peacock, T, Reddy, K, Shelton, H   +6 more
core   +1 more source

Stalking influenza by vaccination with pre-fusion headless HA mini-stem. [PDF]

, 2016
Inaccuracies in prediction of circulating viral strain genotypes and the possibility of novel reassortants causing a pandemic outbreak necessitate the development of an anti-influenza vaccine with increased breadth of protection and potential for rapid ...
A Schneemann, AH Ellebedy, C Ganesh, CJ Wei, D Corti, D Sharma, DC Ekiert, DC Ekiert, DG Higgins, DJ DiLillo, DT O’Hagan, F Ferrara, F Krammer, F Krammer, G Bommakanti, G Bommakanti, J Stevens, J Sui, JJ Skehel, JJ Skehel, JR Whittle, MB Mazanec, NJ Temperton, PH Goff, RD de Vries, S Guthe, S Jegaskanda, S Khurana, SA Valkenburg, TJ Wohlbold, U Rathore, VV Mallajosyula, VV Mallajosyula, W Gerhard, Y Huang, Y Wu   +35 more
core   +2 more sources

Heterologous prime-boost vaccination with H3N2 influenza viruses of swine favors cross-clade antibody responses and protection [PDF]

, 2017
The emergence of multiple novel lineages of H1 and H3 influenza A viruses in swine has confounded control by inactivated vaccines. Because of substantial genetic and geographic heterogeneity among circulating swine influenza viruses, one vaccine strain ...
Claes, Gerwin, Cox, Eric, Krammer, Florian, Mancera Gracia, José Carlos, Qiu, Yu, Sys, Lieve, Trus, Ivan, Van Reeth, Kristien, Versnaeyen, Han   +8 more
core   +2 more sources

Sequential immunization with chimeric hemagglutinin ΔNS1 attenuated influenza vaccines induces broad humoral and cellular immunity

npj Vaccines
Influenza viruses pose a threat to public health as evidenced by severe morbidity and mortality in humans on a yearly basis. Given the constant changes in the viral glycoproteins owing to antigenic drift, seasonal influenza vaccines need to be updated ...
Raveen Rathnasinghe, Lauren A. Chang, Rebecca Pearl, Sonia Jangra, Amy Aspelund, Alaura Hoag, Soner Yildiz, Ignacio Mena, Weina Sun, Madhumathi Loganathan, Nicholas Alexander Crossland, Hans P. Gertje, Anna Elise Tseng, Sadaf Aslam, Randy A. Albrecht, Peter Palese, Florian Krammer, Michael Schotsaert, Thomas Muster, Adolfo García-Sastre   +19 more
doaj   +1 more source

Novel Platforms for the Development of a Universal influenza vaccine [PDF]

, 2018
Despite advancements in immunotherapeutic approaches, influenza continues to cause severe illness, particularly among immunocompromised individuals, young children, and elderly adults.
Ambrose, Ambrose, Antrobus, Atsmon, Babon, Bachmann, Bachmayer, Bahl, Barouch, Barria, Baxter, Belongia, Bessa, Bommakanti, Boon, Borggren, Brady, Brazzoli, Brito, Brown, Brown, Buonaguro, Cardoso, Carroll, Carter, Chen, Chen, Chen, Corti, Corti, Cox, Cross, Das, Deering, DeZure, Dormitzer, Dormitzer, Dormitzer, Draper, Dreyfus, Du, Duvvuri, Ebrahimi, Ermler, Fiers, Foll, Galli, Gamblin, Gao, Geall, Geall, Geiben-Lynn, Giles, Giles, Gorres, Grohskopf, Gross, Gurwith, Hansen, Haynes, Hecker, Hekele, Helenius, Hemann, Hoelscher, Hu, Ionescu, Jang, Jegerlehner, Johansson, Kamlangdee, Kang, Kang, Khurana, Khurana, Kilbourne, Kim, Kim, Kim, Kim, Kon, Krammer, Krammer, Krammer, Kreijtz, Kreijtz, Kreiter, Krystal, Kumar, Kutzler, Lahtinen, Laidlaw, Lambe, Lambert, Laver, Ledgerwood, Lee, Lee, Lee, Lee, Lillie, Lim, Lofano, Low, Magini, Manini, Margine, Matrosovich, Matsuoka, Medina, Medina, Medina, Minor, Mir, Mizuno, Mohn, Molinari, Mooney, Morelli, Moscona, Nachbagauer, Nachbagauer, Neirynck, Okuno, Paliard, Pappas, Park, Pepini, Perche, Perdue, Petsch, Pillet, Ping, Pollard, Price, Price, Quan, Rajão, Ramos, Rao, Rodriguez-Gascon, Roldao, Rollier, Saade, Sahin, Sakabe, Sambhara, Saylor, Scheel, Schild, Schotsaert, Schwartzman, Sekaly, Settembre, Shtyrya, Skountzou, Skowronski, Small, Smith, Sonnberg, Sridhar, Steel, Steinhagen, Stoloff, Sylte, Taubenberger, Thielen, Throsby, Thueng-in, Tisa, Tong, Tree, Uchida, Ulmer, Valero-Pacheco, van der Vries, Van Kampen, Van Lint, Vijaykrishna, Wang, Wang, Wang, Webster, Whittle, Widjaja, Wiersma, Wilks, Wilson, Wohlbold, Wolff, Wollacott, Wong, Yang, Yewdell, Zhao, Zheng, Zhou   +196 more
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