Results 11 to 20 of about 39,970 (276)

An Update of Lectins from Marine Organisms: Characterization, Extraction Methodology, and Potential Biofunctional Applications

Marine Drugs, 2022
Lectins are a unique group of nonimmune carbohydrate-binding proteins or glycoproteins that exhibit specific and reversible carbohydrate-binding activity in a non-catalytic manner.
Mirja Kaizer Ahmmed, Shuva Bhowmik, Stephen G. Giteru, Md. Nazmul Hasan Zilani, Parise Adadi, Shikder Saiful Islam, Osman N. Kanwugu, Monjurul Haq, Fatema Ahmmed, Charlene Cheuk Wing Ng, Yau Sang Chan, Md. Asadujjaman, Gabriel Hoi Huen Chan, Ryno Naude, Alaa El-Din Ahmed Bekhit, Tzi Bun Ng, Jack Ho Wong   +16 more
doaj   +1 more source

Conformational Variability Prediction of H5N1 Avian Influenza A Virus Hemagglutinins with Amino Acid Mutations Using SSSCPreds [PDF]

ACS Omega
Hiroshi Izumi, Laurence A. Nafie, Rina K. Dukor   +2 more
doaj   +2 more sources

Hemagglutinin Structure and Activities [PDF]

Cold Spring Harbor Perspectives in Medicine, 2020
Hemagglutinins (HAs) are the receptor-binding and membrane fusion glycoproteins of influenza viruses. They recognize sialic acid-containing, cell-surface glycoconjugates as receptors but have limited affinity for them, and, as a consequence, virus attachment to cells requires their interaction with several virus HAs. Receptor-bound virus is transferred
Steven J, Gamblin, Sébastien G, Vachieri, Xiaoli, Xiong, Jie, Zhang, Stephen R, Martin, John J, Skehel   +5 more
openaire   +2 more sources

Polymer-Stabilized Sialylated Nanoparticles: Synthesis, Optimization, and Differential Binding to Influenza Hemagglutinins

Biomacromolecules, 2020
During influenza infection, hemagglutinins (HAs) on the viral surface bind to sialic acids on the host cell’s surface. While all HAs bind sialic acids, human influenza targets terminal α2,6 sialic acids and avian influenza targets α2,3 sialic acids.
Sarah-Jane Richards, Alexander N. Baker, M. Walker, M. Gibson   +3 more
semanticscholar   +1 more source

Cloning, Expression, and Purification of the Recombinant Hemagglutinin of Human Influenza Virus H1N1 in the Eukaryotic Insect Cells Using Baculovirus Vector

مجله دانشکده پزشکی اصفهان, 2020
Background: The H1N1 influenza virus is a highly pathogenic virus that threatens human life. Vaccination is an effective way of preventing and controlling influenza.
Niloufar Rashedi, Morteza Taghizadeh, Parisa Mohamadynejad, Mehdi Mahdavi, Reza Jalalirad   +4 more
doaj   +1 more source

Influenza Virus Infection Induces a Narrow Antibody Response in Children but a Broad Recall Response in Adults

mBio, 2020
In contrast to influenza virus vaccination, natural infection induces long-lived and relatively broad immune responses. However, many aspects of the antibody response to natural infection are not well understood.
Philip Meade, Guillermina Kuan, Shirin Strohmeier, Hannah E. Maier, Fatima Amanat, Angel Balmaseda, Kimihito Ito, Ericka Kirkpatrick, Andres Javier, Lionel Gresh, Raffael Nachbagauer, Aubree Gordon, Florian Krammer   +12 more
doaj   +1 more source

Evolutionarily conserved amino acids in MHC-II mediate bat influenza A virus entry into human cells.

PLoS Biology, 2023
The viral hemagglutinins of conventional influenza A viruses (IAVs) bind to sialylated glycans on host cell surfaces for attachment and subsequent infection. In contrast, hemagglutinins of bat-derived IAVs target major histocompatibility complex class II
Okikiola M Olajide, Maria Kaukab Osman, Jonathan Robert, Susanne Kessler, Lina Kathrin Toews, Thiprampai Thamamongood, Jacques Neefjes, Antoni G Wrobel, Martin Schwemmle, Kevin Ciminski, Peter Reuther   +10 more
doaj   +1 more source

Detection of H1 Swine Influenza A Virus Antibodies in Human Serum Samples by Age Group

Emerging Infectious Diseases, 2020
Most H1 influenza A viruses (IAVs) of swine are derived from past human viruses. As human population immunity against these IAVs gradually decreases, the risk of reintroduction to humans increases. We examined 549 serum samples from persons 0–97 years of
Elien Vandoorn, Isabel Leroux-Roels, Geert Leroux-Roels, Anna Parys, Amy Vincent, Kristien Van Reeth   +5 more
doaj   +1 more source

Influenza hemagglutinin membrane anchor [PDF]

Proceedings of the National Academy of Sciences, 2018
Viruses with membranes fuse them with cellular membranes, to transfer their genomes into cells at the beginning of infection. For Influenza virus, the membrane glycoprotein involved in fusion is the hemagglutinin (HA), the 3D structure of which is known from X-ray crystallographic studies.
Donald J. Benton, Andrea Nans, Lesley J. Calder, Jack Turner, Ursula Neu, Yi Pu Lin, Esther Ketelaars, Nicole L. Kallewaard, Davide Corti, Antonio Lanzavecchia, Steven J. Gamblin, Peter B. Rosenthal, John J. Skehel   +12 more
openaire   +3 more sources

Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses

Nature Immunology, 2018
The present vaccine against influenza virus has the inevitable risk of antigenic discordance between the vaccine and the circulating strains, which diminishes vaccine efficacy.
M. Kanekiyo, M. Joyce, Rebecca A. Gillespie, J. Gallagher, Sarah F. Andrews, Hadi M. Yassine, A. Wheatley, Brian E. Fisher, D. Ambrozak, A. Creanga, K. Leung, E. Yang, Seyhan Boyoglu-Barnum, I. Georgiev, Y. Tsybovsky, Madhu Prabhakaran, H. Andersen, W. Kong, U. Baxa, Kathryn L. Zephir, J. Ledgerwood, R. Koup, P. Kwong, Audray K. Harris, A. McDermott, J. Mascola, B. Graham   +26 more
semanticscholar   +1 more source