Results 31 to 40 of about 99,201 (311)

RXR Agonists Enhance Lenalidomide Anti-Myeloma Activity and T Cell Functions while Retaining Glucose-Lowering Effect

Cells, 2023
Retinoid X receptor (RXR) heterodimerizes with the PPAR nuclear hormone receptor and regulates its downstream events. We investigated the effects of RXR agonists (LG100754, bexarotene, AGN194204, and LG101506) on lenalidomide’s anti-myeloma activity, T ...
Jian Wu, Xiaobei Wang, Min Zhang, Parker Mathews, Yubin Kang   +4 more
doaj   +1 more source

1q triplication in hematologic malignancies [PDF]

, 2010
Review on 1q triplication in hematologic malignancies, with data on clinics, and the genes ...
Park, TS, Choi, JR, JR Choi, TS Park
core   +1 more source

Efficacy of immune suppression tapering in treating relapse after reduced intensity allogeneic stem cell transplantation

Haematologica, 2015
For patients who relapse after allogeneic hematopoietic stem cell transplantation while still on immune suppression, there is anecdotal evidence that tapering the immune suppression may result in graft-versus-tumor activity.
Natasha Kekre, Haesook T. Kim, Gita Thanarajasingam, Philippe Armand, Joseph H. Antin, Corey Cutler, Sarah Nikiforow, Vincent T. Ho, John Koreth, Edwin P. Alyea, Robert J. Soiffer   +10 more
doaj   +1 more source

Imaging Musculoskeletal Manifestations of Pediatric Hematologic Malignancies

, 2021
OBJECTIVE. The purpose of this article is to describe imaging findings of common and uncommon musculoskeletal manifestations, posttreatment changes, and complications of pediatric hematologic malignancies. CONCLUSION.
Cohen, Sara, Golja, Anna M., Schwartz, Daniel M., Noda, Sakura, Tannenbaum, Melissa F., Rissmiller, Julia G.   +5 more
core   +1 more source

Targeting the integrated stress response in hematologic malignancies [PDF]

, 2022
While numerous targeted therapies have been recently adopted to improve the treatment of hematologic malignancies, acquired or intrinsic resistance poses a significant obstacle to their efficacy.
Nwosu, Gus O., Pitson, S.M., Nwosu, G.O., Powell, J.A., Pitson, Stuart M., Powell, Jason A.   +5 more
core   +1 more source

Enhanced CAR-T activity against established tumors by polarizing human T cells to secrete interleukin-9

Nature Communications, 2020
Antigen-specific IL9-secreting CD4 Th9 and CD8 Tc9 cells have been previously characterized for their anti-tumour properties. Here, the authors show that ex vivo polarized Th9/Tc9 human CAR-T cells display increased anti-tumor activity in pre-clinical ...
Lintao Liu, Enguang Bi, Xingzhe Ma, Wei Xiong, Jianfei Qian, Lingqun Ye, Pan Su, Qiang Wang, Liuling Xiao, Maojie Yang, Yong Lu, Qing Yi   +11 more
doaj   +1 more source

Whole tumor cell vaccines engineered to secrete GM‐CSF (GVAX)

ImmunoMedicine, 2021
Generation of immunity against cancer through vaccination has long been an elusive goal for tumor immunologists. Putative candidates for vaccination targets include oncofetal antigens, viral antigens, neoantigens, and differentiation antigens.
Robert J. Soiffer, Kameron A. Kooshesh, Vincent Ho   +2 more
doaj   +1 more source

Top 100 Cited Articles on Clinical Hematopoietic Stem Cell Transplantation: A Bibliometric Analysis

Frontiers in Medicine, 2022
We conducted a bibliometric analysis to identify scholarly impact and factors associated with the top 100 cited articles on clinical hematopoietic stem cell transplantation (HSCT). In January 2021, a title-specific search was conducted.
Moazzam Shahzad, Moazzam Shahzad, Sibgha Gull Chaudhary, Iqra Anwar, Muhammad Arslan, Zehra Naseem, Naira T. Fatima, Sakina Abbas, Tayyaba Ali, Raheel S. Siddiqui, Peiman Hematti, Sunil H. Abhyankar, Joseph P. McGuirk, Muhammad Umair Mushtaq   +13 more
doaj   +1 more source

Stimulation of Potent Humoral and Cellular Immunity via Synthetic Dual-Antigen MVA-Based COVID-19 Vaccine COH04S1 in Cancer Patients Post Hematopoietic Cell Transplantation and Cellular Therapy

Vaccines, 2023
Hematopoietic cell transplantation (HCT) and chimeric antigen receptor (CAR)-T cell patients are immunocompromised, remain at high risk following SARS-CoV-2 infection, and are less likely than immunocompetent individuals to respond to vaccination.
Flavia Chiuppesi, Sandra Ortega-Francisco, Miguel-Angel Gutierrez, Jing Li, Minh Ly, Katelyn Faircloth, Jada Mack-Onyeike, Corinna La Rosa, Sandra Thomas, Qiao Zhou, Jennifer Drake, Cynthia Slape, Paolo Fernando, Wasima Rida, Teodora Kaltcheva, Alba Grifoni, Alessandro Sette, Angela Patterson, Shannon Dempsey, Brian Ball, Haris Ali, Amandeep Salhotra, Anthony Stein, Nitya Nathwani, Michael Rosenzweig, Liana Nikolaenko, Monzr M. Al Malki, Jana Dickter, Deepa D. Nanayakkara, Alfredo Puing, Stephen J. Forman, Randy A. Taplitz, John A. Zaia, Ryotaro Nakamura, Felix Wussow, Don J. Diamond, Sanjeet S. Dadwal   +36 more
doaj   +1 more source

Familial Risk and Heritability of Hematologic Malignancies in the Nordic Twin Study of Cancer [PDF]

, 2021
We aimed to explore the genetic and environmental contributions to variation in the risk of hematologic malignancies and characterize familial dependence within and across hematologic malignancies.
Jonas Mengel-From, Harris, Jennifer R., Bonat, Wagner H, Hjelmborg, J. v. B., Clemmensen, Signe B., Clemmensen, Signe B.; id_orcid, Henrik Frederiksen, Jaakko Kaprio, Frederiksen, Henrik, Hjelmborg, Jacob v. B., Mengel-From, Jonas, Harris, Jennifer Ruth, Jennifer R. Harris, Wagner H. Bonat, Jacob v. B. Hjelmborg, Kaprio, Jaakko, Signe B. Clemmensen, Frederiksen, Henrik; id_orcid, Bonat, Wagner H., Hjelmborg, Jacob V.B.; id_orcid   +19 more
core   +1 more source