Results 51 to 60 of about 99,201 (311)

XPO1 blockade with KPT-330 promotes apoptosis in cutaneous T-cell lymphoma by activating the p53–p21 and p27 pathways

Scientific Reports
Dysregulated nuclear-cytoplasmic trafficking has been shown to play a role in oncogenesis in several types of solid tumors and hematological malignancies. Exportin 1 (XPO1) is responsible for the nuclear export of several proteins and RNA species, mainly
Nitin Chakravarti, Amy Boles, Rachel Burzinski, Paola Sindaco, Colleen Isabelle, Kathleen McConnell, Anjali Mishra, Pierluigi Porcu   +7 more
doaj   +1 more source

The Distribution and Phenotypes of Blood Groups in Hematologic Malignancies

, 2023
Objective: Blood groups are associated with duodenal ulcer, diabetes mellitus, and urinary tract infection. In some studies, a relationship was detected between hematologic and solid organ malignancies and blood groups. In this study, we investigated the
Gulden Sincan, SİNCAN, GÜLDEN, ERDEMİR, METE, ERDEM, FUAT, Mete Erdemir, Fuat Erdem   +5 more
core   +1 more source

Validation of the FACT-G7 in patients with hematologic malignancies [PDF]

, 2023
BackgroundIt is essential to evaluate the quality of life in patients with hematologic malignancies to reflect the therapeutic effect and prognosis, but lengthy assessments are often burdensome. The 7-Item Functional Assessment of Cancer Therapy-General (
Ling Mao, Yamei Leng, Xinwen Du, Fengjiao Chen   +3 more
core   +1 more source

Venous Thromboembolism in Pediatric Bone Sarcoma Patients: A 10‐Year, Single‐Institution Experience Encompassing the COVID‐19 Pandemic

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Osteosarcoma (OS) and Ewing sarcoma (EWS) are the most common primary bone cancers in children, but acute thrombosis is poorly characterized in this population. Our study evaluated the rates of venous thromboembolism (VTE) and associated risk factors in pediatric patients with bone sarcomas treated over a 10‐year period encompassing
Sarah Kappa, Shou Xu, Mark Zobeck, Sarah E. Sartain, Nino Rainusso, Lisa Wang, Nicole Montgomery, Paige Wheaton, Sarah Whittle   +8 more
wiley   +1 more source

Utility of neurotoxicity investigations in CD19 and BCMA CART recipients with ICANS

Blood Immunology & Cellular Therapy
: Immune effector cell–associated neurotoxicity syndrome (ICANS) is a potentially life-threatening toxicity of chimeric antigen receptor T-cell (CART) therapy, graded according to American Society for Transplantation and Cellular Therapy (ASTCT ...
Lauren N. Scott, Benjamin Hane, William Wesson, Pilar Thangwaritorn, Raeef Rahman, Marc Hoffmann, Forat Lutfi, Zahra Mahmoudjafari, Sunil Abhyankar, Dinesh Pal Mudaranthakam, Muhammad Umair Mushtaq, Joseph McGuirk, Al-Ola Abdallah, Muhammad Mahdi Nashatizadeh, Nausheen Ahmed   +14 more
doaj   +1 more source

A phase II trial of sequential ribonucleotide reductase inhibition in aggressive myeloproliferative neoplasms

Haematologica, 2014
Myeloproliferative neoplasms are a varied group of disorders that can have prolonged chronic phases, but eventually accelerate and can transform into a secondary acute myeloid leukemia that is ultimately fatal.
Joshua F. Zeidner, Judith E. Karp, Amanda L. Blackford, B. Douglas Smith, Ivana Gojo, Steven D. Gore, Mark J. Levis, Hetty E. Carraway, Jacqueline M. Greer, S. Percy Ivy, Keith W. Pratz, Michael A. McDevitt   +11 more
doaj   +1 more source

Autophagy in Hematological Malignancies

Cancers, 2022
Autophagy is a highly conserved metabolic pathway via which unwanted intracellular materials, such as unfolded proteins or damaged organelles, are digested. It is activated in response to conditions of oxidative stress or starvation, and is essential for the maintenance of cellular homeostasis and other vital functions, such as differentiation, cell ...
Olga García Ruiz, José Manuel Sánchez-Maldonado, Miguel Ángel López-Nevot, Paloma García, Angelica Macauda, Francisca Hernández-Mohedo, Pedro Antonio González-Sierra, Manuel Martínez-Bueno, Eva Pérez, Fernando Jesús Reyes-Zurita, Daniele Campa, Federico Canzian, Manuel Jurado, Juan José Rodríguez-Sevilla, Juan Sainz   +14 more
openaire   +5 more sources

Serological Benefit of SARS‐CoV‐2 Vaccination Relative to Infection in Children With Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with acute lymphoblastic leukemia (ALL) are at risk of severe outcomes from SARS‐CoV‐2 (SCV2). In the post‐pandemic context, where most children have been infected with SCV2, there are limited data on whether vaccination remains beneficial in children with ALL.
Janna R. Shapiro, Freda Qi, Karen Colwill, Alina D. Dorogy, Ying Liu, Michelle Science, Anne‐Claude Gingras, James M. Rini, Sumit Gupta, Sarah Alexander, Shelly Bolotin, Tania H. Watts   +11 more
wiley   +1 more source

Plerixafor (a CXCR4 antagonist) following myeloablative allogeneic hematopoietic stem cell transplantation enhances hematopoietic recovery

Journal of Hematology & Oncology, 2016
Background The binding of CXCR4 with its ligand (stromal-derived factor-1) maintains hematopoietic stem/progenitor cells (HSPCs) in a quiescent state.
Michael M. B. Green, Nelson Chao, Saurabh Chhabra, Kelly Corbet, Cristina Gasparetto, Ari Horwitz, Zhiguo Li, Jagadish Kummetha Venkata, Gwynn Long, Alice Mims, David Rizzieri, Stefanie Sarantopoulos, Robert Stuart, Anthony D. Sung, Keith M. Sullivan, Luciano Costa, Mitchell Horwitz, Yubin Kang   +17 more
doaj   +1 more source

Direct Oral Anticoagulants In Patients With Hematologic Malignancies

, 2020
The anticoagulant treatment for patients with hematologic malignancies is low molecular weight heparin (LMWH), considered the safest in this particular patients setting. Although direct oral anticoagulants (DOACs) have proven their efficacy and safety in
Chistolini, Antonio, Maria L. De Luca, Serrao, Alessandra, Santoro, Cristina, Alessandra Serrao, Luciano Fiori, Antonietta Ferretti, Ferretti, Antonietta, De Luca, Giulia, Cristina Santoro, Antonio Chistolini, Ligia, Silvio, Fiori, Luciano, Massimo Breccia, Mohamed, Sara, Gianfranco Lapietra, Sara Mohamed, Lapietra, Gianfranco, De Luca, Maria Lucia, Breccia, Massimo, Giulia De Luca, Silvio Ligia   +21 more
core   +1 more source