Results 71 to 80 of about 99,201 (311)

PHF6 Mutations in Hematologic Malignancies [PDF]

, 2021
Next generation sequencing has uncovered several genes with associated mutations in hematologic malignancies that can serve as potential biomarkers of disease. Keeping abreast of these genes is therefore of paramount importance in the field of hematology.
Olga K. Weinberg, Weinberg, Olga K., Kurzer, Jason H., Jason H. Kurzer   +3 more
core   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Evolution to complex karyotype disease in mono-allelic TP53-mutated myelodysplastic syndrome/acute myeloid leukemia: a cohort study

Haematologica
Not available.
Priyanka Fernandes, Sergiu Pasca, Tania Jain, Mark J. Levis, Alexander J. Ambinder, Laura Walsh, Ivana Gojo, Douglas B. Smith, Jonathan Webster, Gabriel Ghiaur, W. Brian Dalton, Gabrielle Prince, Richard J. Jones, Amy E. DeZern, Lukasz P. Gondek, Theodoros Karantanos   +15 more
doaj   +1 more source

Venous thromboembolism is associated with graft-versus-host disease and increased non-relapse mortality after allogeneic hematopoietic stem cell transplantation

Haematologica, 2017
Although venous thromboembolism rates and risk factors are well described in patients with cancer, there are limited data on the incidence, risk factors and outcomes of thrombosis after allogeneic stem cell transplantation, a curative therapy for ...
Natasha Kekre, Haesook T. Kim, Vincent T. Ho, Corey Cutler, Philippe Armand, Sarah Nikiforow, Edwin P. Alyea, Robert J. Soiffer, Joseph H. Antin, Jean M. Connors, John Koreth   +10 more
doaj   +1 more source

Outcomes with mismatched unrelated donor allogeneic hematopoietic stem cell transplantation in adults: A systematic review and meta-analysis

Frontiers in Oncology, 2022
BackgroundAllogeneic hematopoietic stem cell transplantation (HSCT) is a potentially curative therapy for various hematologic disorders. Alternative donor strategies such as mismatched unrelated donors (MMUD) offer the option of HSCT to patients lacking ...
Muhammad Umair Mushtaq, Moazzam Shahzad, Moazzam Shahzad, Ezza Tariq, Ezza Tariq, Qamar Iqbal, Sibgha Gull Chaudhary, Muhammad U. Zafar, Iqra Anwar, Nausheen Ahmed, Rajat Bansal, Anurag K. Singh, Sunil H. Abhyankar, Natalie S. Callander, Peiman Hematti, Joseph P. McGuirk   +15 more
doaj   +1 more source

Increased Risk of Sarcomas in Children With Congenital Anomalies: Findings From the Genetic Overlap Between Anomalies and Cancer in Kids (GOBACK) Registry Linkage Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric sarcomas are a heterogeneous group of tumors that contribute disproportionately to cancer mortality in children. Although congenital anomalies are among the strongest known risk factors for childhood cancer, the risk of specific sarcoma subtypes among affected individuals has not yet been thoroughly evaluated. Procedure We
Russ Wolters, Ji Yun Tark, Tiffany M. Chambers, Tania A. Desrosiers, Michael E. Scheurer, Charles Shumate, Wendy N. Nembhard, Mahsa M. Yazdy, Eirini Nestoridi, Amanda E. Janitz, Jean Paul Tanner, Russell S. Kirby, Jason L. Salemi, Yao Yu, Chad D. Huff, Sharon E. Plon, Philip J. Lupo, Jeremy M. Schraw   +17 more
wiley   +1 more source

Treatment of Relapsed/Refractory t(11;14) Multiple Myeloma and High-Risk Myelodysplastic Syndrome With Venetoclax

Case Reports in Hematology
Patients with multiple myeloma (MM) have an inherent risk for secondary myeloid malignancies. Innovative approaches to treatment are needed when these hematologic malignancies co-occur.
Allison O. Taylor, Stephanie Clune, JoAnn Liu, Cristina Gasparetto, Thomas W. LeBlanc   +4 more
doaj   +1 more source

Immunotherapy for hematological malignancies

JoLS, Journal of Life Sciences, 2019
Tumor immune tolerance remains a major barrier for effective anti-cancer therapy. A growing number of pathways whereby solid tumors escape immune surveillance have been characterized (1). This progress led us to revisit the "hallmarks of cancer" and brought forward many promising immunotherapies.
Shuai, Dong, Irene M, Ghobrial
openaire   +2 more sources

S100A8 and S100A9 in Hematologic Malignancies: From Development to Therapy

, 2023
S100A8 and S100A9 are multifunctional proteins that can initiate various signaling pathways and modulate cell function both inside and outside immune cells, depending on their receptors, mediators, and molecular environment.
Jaebok Choi, Abdul-Jalil Dania, Dania, Abdul-Jalil, Sena Kim, Razmkhah, Farnaz, Kim, Sena, Choi, Jaebok, Farnaz Razmkhah, Lim, Sora, Sora Lim   +9 more
core   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source