Results 151 to 160 of about 395,898 (355)
Hematopoietic Stem Cells and Hematopoiesis
Cancer Control, 2003 Background The highly orchestrated process of blood cell development and homeostasis is termed “hematopoiesis.” Understanding the biology of hematopoietic stem cells as well as hematopoiesis is important to developing improved treatments for hematologic malignancies, congenital disorders, chemotherapy-related cytopenias, and blood and marrow ...
openaire +2 more sources
Parasubthalamic Glutamatergic Neurons Coordinate Cardiovascular Homeostasis and Locomotion in Mice
Advanced Science, EarlyView.PSTNVglut2 neurons function as a new central baroreflex hub via projections to the NTS, modulating parasympathetic cardiac output to maintain cardiovascular homeostasis while synchronously regulating locomotion. Blood pressure fluctuations negatively correlate with locomotor performance.
Ming‐Xuan Lu +8 more
wiley +1 more source
Proliferation and differentiation of hematopoietic stem cells in long-term cultures of adult hamster spleen. [PDF]
, 1982 Eugene A. Arnold +2 more
openalex +1 more source
Lifespan‐Regulated CAR‐Macrophages from Myeloid Progenitors for Enhanced Colorectal Cancer Therapy
Advanced Science, EarlyView.Using a tamoxifen‐inducible Hoxb8 system, proliferative bone marrow progenitors can be generated, which are subsequently engineered with an anti‐CEA CAR construct containing a suicide gene (iCas9) and differentiated into CAR‐macrophages. This method facilitates scale up the production of CAR‐macrophages.
Chuancheng Gao +8 more
wiley +1 more source
Altered stem cell (CFU-S) function following infection of hematopoietic cells with a virus carrying V-src [PDF]
, 1986 David Boettiger, TM Dexter
openalex +1 more source
Advanced Science, EarlyView.Short‐term intravenous treatments with iPSC‐derived mononuclear phagocytes (iMPs) improve cognitive decline and neural health in two mouse models of aging and in the 5xFAD mouse model of Alzheimer's disease. iMPs reduce levels of serum amyloid proteins that increase in aging and improve the health of hippocampal microglia and mossy cells.
V. Alexandra Moser +11 more
wiley +1 more source
Advanced Science, EarlyView.Nrf2 isn't just a protector—it's a driver of cancer stemness. The study uncovers how arsenic‐activated Nrf2 directly upregulates KLF4, a key pluripotency factor, fueling oncogenic reprogramming. Through enhancer activation and self‐reinforcing loop, Nrf2 and KLF4 co‐opt gene networks linked to epithelial‐to‐mesenchymal transition and tumor growth ...
Ziwei Wang +9 more
wiley +1 more source
Advanced Science, EarlyView.PAD1 is upregulated within the CD133+ subset or cisplatin‐resistant ovarian cancer cells, which is positively associated with the upregulation of stemness‐related markers and maintenance of stemness in OCSLCs. Mechanistically, PAD1‐catalyzed AKT2 citrullination at R202 facilitates AKT2 phosphorylation, promoting CEBPβ expression and its binding to the ...
Teng Xue +10 more
wiley +1 more source
Canine pluripotent hematopoietic stem cells and CFU-GM express Ia-like antigens as recognized by two different class II-specific monoclonal antibodies [PDF]
, 1987 F Schuening +6 more
openalex +1 more source