Results 171 to 180 of about 1,175,170 (409)

Safety and Efficacy of Adoptive Transfer of Stem Cell Memory Enriched Virus Specific T Cells against CMV and EBV

Advanced Science, EarlyView.
This study finds that CD8⁺ TSCM cells exhibit superior self‐renewal, differentiation, and antiviral activity. Transcriptome and epigenome analyses highlight MAPK cascade regulation in TSCM cells. In vivo, virus‐specific TSCM cells show enhanced persistence and tumor protection.
Xun‐Hong Cao, Xu‐Ying Pei, Yuan‐Yuan Zhang, Juan Xie, Jing‐Wei Tu, Zhuo‐Jun Liu, Yi‐Yang Ding, Chen‐Hua Yan, Yu‐Hong Chen, Yu Wang, Lan‐Ping Xu, Xiao‐Hui Zhang, Xiao‐Jun Huang, Xiang‐Yu Zhao   +13 more
wiley   +1 more source

Autologous, Gene-Modified Hematopoietic Stem and Progenitor Cells Repopulate the Central Nervous System with Distinct Clonal Variants [PDF]

, 2019
Christopher W. Peterson, Jennifer E. Adair, Martin E. Wohlfahrt, Claire Deléage, Stefan Radtke, Blake J. Rust, Krystin K. Norman, Zachary K. Norgaard, Lauren E. Schefter, Gabriella Sghia-Hughes, Andrea C. Repetto, Audrey Baldessari, Robert D. Murnane, Jacob D. Estes, Hans‐Peter Kiem   +14 more
openalex   +1 more source

Site‐Specific Mitochondrial RNA N1‐Methyladenosine Demethylation via an Engineered MTS‐PUF‐ALKBH3 Fusion Protein

Advanced Science, EarlyView.
A CRISPR‐free mitochondrial RNA m1A demethylation (MRD) editor combining MTS, PUF proteins, and ALKBH3 enables precise m1A removal from mitochondrial mRNA and tRNA, which influences mitochondrial protein levels, cellular proliferation, ATP production, and mitochondrial respiration. Subsequently, in vivo demethylation of the m1A modification is achieved
Xiangrui Li, Deqiang Kong, Hongmei Liu, Jie Yang, Jiale Zhou, Yuqiang Qian, Ding Zhao, Jinze Li, Xinyu Wu, Tao Zhang, Xiaodi Sun, Yang Han, Liangxue Lai, Zhanjun Li   +13 more
wiley   +1 more source

Fine-tuning Hematopoiesis: Microenvironmental factors regulating self-renewal and differentiation of hematopoietic stem cells [PDF]

, 2010
__Abstract__ Hematopoietic stem cells (HSCs) have the ability to self renew and generate all lineages of blood cells. Although it is currently well established that hematopoietic stem cells (HSCs) regenerate the blood compartment, it was only in the
Luis, T.C. (Tiago)
core  

Single‐Cell Insights Into Macrophage Subtypes in Pulmonary Infections

Advanced Science, EarlyView.
This review highlights the dynamic plasticity of macrophages during pulmonary infections and proposes an integrative framework defining six functional subtypes: Inflam‐Ms, Hub‐Ms, Reg‐Ms, Prolif‐Ms, Memory‐Ms, and Senesc‐Ms. Single‐cell omics delineate their distinct roles in homeostasis and infection, refining our understanding of macrophage ...
Zhaoheng Lin, Yuxiao Zheng, Yu Zhong, Hongyan Wang   +3 more
wiley   +1 more source

P093 | ASSESSING HEREDITARY MYELOID NEOPLASMS THROUGH TARGETED NEXT GENERATION SEQUENCING PANEL DESIGN AND DEFINITION OF CLINICAL CRITERIA: A PILOT STUDY

Haematologica
Hereditary myeloid neoplasms with germline predisposition represent an emerging category within the spectrum of myelodysplastic and myeloproliferative syndromes.
E. Ronda, E. Borotti, N. Codeluppi, E. Follini, L. Pochintesta, A. Rossi, D. Vallisa   +6 more
doaj  

Evidence for adequate thymic function but impaired naive T-cell survival following allogeneic hematopoietic stem cell transplantation in the absence of chronic graft-versus-host disease [PDF]

, 2003
Jean‐François Poulin
openalex   +1 more source

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

Science, 2012
Christian Schulz, Elisa Gomez Perdiguero, Laurent Chorro, H. Szabo-Rogers, N. Cagnard, Katrin Kierdorf, M. Prinz, Bishan Wu, S. Jacobsen, J. Pollard, J. Frampton, Karen J. Liu, F. Geissmann   +12 more
semanticscholar   +1 more source

FXYD3 Promotes Tumor Progression by Binding With IRF7 to Regulate JAK2/STAT5 Signaling in Intrahepatic Cholangiocarcinoma

Advanced Science, EarlyView.
FXYD3 binds IRF7 via its 60–87aa domain, triggering a cGAS/STING‐mediated positive feedback loop amplified by type I interferon. This sustains JAK2/STAT5 activation, accelerating ICC progression. Targeting FXYD3 with siFXYD3@PEP suppresses tumors and enhances chemotherapy sensitivity. Abstract Intrahepatic cholangiocarcinoma (ICC) has a poor prognosis,
Yan Zhou, Xiaofeng Shen, Shuo Zhang, XiaoHong Pu, Zipeng Xu, Xiang Zhao, Wei Feng, Yuan Liang, Xingtao He, Aihua Yang, Yudong Qiu, Yihang Yuan, Chaobo Chen, Jun Chen   +13 more
wiley   +1 more source

Single Cell Phenotyping Reveals Heterogeneity Among Hematopoietic Stem Cells Following Infection [PDF]

, 2017
Adam L. MacLean, Maia A. Smith, Juliane Liepe, Aaron Sim, Reema Khorshed, Narges Rashidi, Nico Scherf, Axel Krinner, Ingo Roeder, Cristina Lo Celso, Michael P. H. Stumpf   +10 more
openalex   +1 more source