Results 231 to 240 of about 395,898 (355)

Molecular evidence that in situ-transduced fetal liver hematopoietic stem/progenitor cells give rise to medullary hematopoiesis in adult rats [PDF]

, 1995
D. Wade Clapp, Brian Freie, Lee Wh, YY Zhang   +3 more
openalex   +1 more source

Enhancing Spatial Transcriptomics via Spatially Constrained Matrix Decomposition with EDGES

Advanced Science, EarlyView.
Imaging‐based spatial transcriptomics technologies are currently limited by their restricted gene detection capacity and low measurement accuracy. Moreover, the insufficient integration of spatial context and single‐cell reference data poses a significant challenge for comprehensive data analysis.
Jinyue Zhao, Jiating Yu, Yuqing Cao, Fan Yuan, Ling‐Yun Wu, Duanchen Sun   +5 more
wiley   +1 more source

High doses of purified stem cells cause early hematopoietic recovery in syngeneic and allogeneic hosts. [PDF]

, 1998
Naoshige Uchida, Atsushi Tsukamoto, Daqian He, Annabelle M. Friera, Roland Scollay, Irving L. Weissman   +5 more
openalex   +1 more source

The role of 67 kDa laminin receptor in G-CSF-induced hematopoietic stem cell mobilization [PDF]

, 2007
Visconte, Valeria
core   +1 more source

Insights into the Mechanisms of Immune‐Checkpoint Inhibitors Gained from Spatiotemporal Dynamics of the Tumor Microenvironment

Advanced Science, EarlyView.
This review summarizes recent advances in the spatiotemporal dynamics of the tumor microenvironment (TME). It highlights the roles of diverse immune and stromal cell populations, spatial architecture of the TME, as well as the gut and tumor microbiota in influencing responses to immune checkpoint inhibitors (ICIs), by integrating insights from single ...
Yuanyuan Zhang, Zhihua Liu
wiley   +1 more source

Prenatal Exposure to Chemotherapy Increases the Mutation Burden in Human Neonatal Hematopoietic Stem Cells. [PDF]

Cancer Discov
Struys I, Velázquez C, Ubels J, LeJeune CL, van Roosmalen MJ, Rosendahl Huber AKM, van Leeuwen AJCN, Bossuyt W, Thienpont B, Voet T, Van Calsteren K, Lenaerts L, van Boxtel R, Amant F.   +13 more
europepmc   +1 more source

Functional Characterization of a Novel Hematopoietic Stem Cell and Its Place in the c-Kit Maturation Pathway in Bone Marrow Cell Development [PDF]

, 1999
Mariaestela Ortiz, John W. Wine, N Lohrey, Francis W. Ruscetti, Sally E. Spence, Jonathan R. Keller   +5 more
openalex   +1 more source

Leukemic Cells Hijack Stromal Bioelectricity to Reprogram the Bone Marrow Niche via CaV1.2‐Dependent Mechanisms

Advanced Science, EarlyView.
Leukemic blasts induce membrane depolarization in mesenchymal stromal cells (MSCs), contributing to a dysfunctional niche that favors leukemia progression. Here, it is demonstrated that restoring the expression of CaV1.2 calcium channel in AML‐MSCs repolarizes their membrane potential, reprogramming them toward a healthy phenotype.
Ambra Da Ros, Maddalena Benetton, Giulia Borella, Giorgia Longo, Giulia Borile, Alice Cani, Diego Lopez‐Pigozzi, Mario Bortolozzi, Silvia Bresolin, Claudia Tregnago, Franco Locatelli, Martina Pigazzi   +11 more
wiley   +1 more source

Phase separation participates in the genetic regulation mechanism of hematopoietic stem cells: potential therapeutic methods. [PDF]

Stem Cell Res Ther
Tang X, Wang Y, Xu R.
europepmc   +1 more source

Energy Deficiency‐Induced ATG4B Nuclear Translocation Inhibits PRMT1‐Mediated DNA Repair and Promotes Leukemia Progression

Advanced Science, EarlyView.
This study demonstrated that ATG4B translocates from the cytoplasm to the nucleus during energy deficiency. Nuclear ATG4B inhibits DNA repair by interacting with PRMT1. The nuclear ATG4B‐mediated DNA repair defect is significantly exacerbated within acute myeloid leukemia (AML) cells, promoting leukemia progression in an AML mouse model.
Zhenkun Wang, Xianli Zhang, Yuanyuan Zhou, Shuyi Lin, Yuting Fu, Haiping Liu, Qiongdan Gao, YanHong Xiao, Zhao Yin, Shuang Liu, Kexiu Huang, Suqi Deng, Juan Du, Hui Zeng, Jia Wang, Jinping Zheng, Qinghua Zhou, Tianfeng Chen, Xiaoling Gao, Zhenyu Ju, Bo Liu   +20 more
wiley   +1 more source