Results 281 to 290 of about 395,898 (355)

From Genome to Geroscience: How DNA Damage Shapes Systemic Decline

BioEssays, EarlyView.
Persistent DNA damage triggers systemic secretory responses including damage‐associated molecular patterns (DAMPs), the senescence‐associated secretory phenotype (SASP), and extracellular vesicles (EVs). This non‐cell‐autonomous signaling disrupts intercellular communication, driving organism‐wide dysfunction and aging, and offering new therapeutic ...
Athanasios Siametis, George A. Garinis
wiley   +1 more source

Super-resolution imaging informed scRNA sequencing analysis reveals the critical role of GDF15 in rejuvenating aged hematopoietic stem cells. [PDF]

Blood Sci
Shi Z, Zhang X, Yang H, Zheng X, Niu M, Zhang Y, Yuan P, Wei W, Huang G, Fang R, Chen L.   +10 more
europepmc   +1 more source

Taking Down the Primary Cilium: Pathways for Disassembly in Differentiating Cells

BioEssays, EarlyView.
Primary cilia are developmentally essential subcellular signaling compartments. However, many differentiated cells lack primary cilia, and cilia disassembly in these tissue contexts has been largely overlooked. We highlight several pathways for primary cilia loss and examine how changes in ciliation states could contribute to diverse pathologies ...
Carolyn M. Ott, Saikat Mukhopadhyay
wiley   +1 more source

Predictive factors for engraftment kinetics of autologous hematopoietic stem cells in children. [PDF]

Hematol Transfus Cell Ther
Andrić B, Vujić D, Šerbić O, Radonjić Z, Simić M, Kuzmanović M.   +5 more
europepmc   +1 more source

Scalable, High‐Density Expansion of Human Mesenchymal Stem Cells on Microcarriers Using the Bach Impeller in Stirred‐Tank Reactors

Biotechnology and Bioengineering, EarlyView.
ABSTRACT This paper describes the results of process developmental experiments to achieve higher cell densities in the manufacturing of hMSCs using the novel Bach impeller in a stirred‐tank bioreactor. Engineering experiments have previously shown that the Bach impeller represents an efficient mixing device that suspends particles in fluids at low ...
Tom A. Wyrobnik, Laia Miranda, Alan Lam, Steve Oh, Andrea Ducci, Martina Micheletti   +5 more
wiley   +1 more source

A new double reporter strategy reveals a subset of non-migratory hematopoietic stem cells localized in a dynamic bone marrow niche

Secchi MA, Liu Q, Antón SG, Mai C, Jibril A, Xu J, O’Carroll D, Wilson NK, Kranc KR, Göttgens B, Celso CL, Luis TC.   +11 more
europepmc   +1 more source

Impact of PFOS Exposure on Murine Fetal Hematopoietic Stem Cells, Associated with Intrauterine Metabolic Perturbation. [PDF]

Environ Sci Technol
Lee WK, Wan HT, Cheng Z, Chan WY, Lam TKY, Lai KP, Wang J, Cai Z, Wong CKC.   +8 more
europepmc   +1 more source

Engineering antibodies with cancer‐associated binding sites

BMEMat, EarlyView.
This review describes antibodies that perform direct/indirect roles in cancer treatment by binding to effective targets and discusses how antibodies kill tumors and modulate tumor microenvironment through these targets. The classification of expression systems for antibody production is summarized to guide appropriate selection based on different ...
Yinqi Tian, Yumeng Pan, Yingchun Zhang, Fangling Wang, Zejun Wang   +4 more
wiley   +1 more source

Correction: Targeting stem cell niche can protect hematopoietic stem cells from chemotherapy and G-CSF treatment. [PDF]

Stem Cell Res Ther
Li S, Zou D, Li C, Meng H, Sui W, Feng S, Cheng T, Zhai Q, Qiu L.   +8 more
europepmc   +1 more source