Osteoblast Derived Exosomes Alleviate Radiation- Induced Hematopoietic Injury
Frontiers in Bioengineering and Biotechnology, 2022 As hematopoietic stem cells can differentiate into all hematopoietic lineages, mitigating the damage to hematopoietic stem cells is important for recovery from overdose radiation injury.
Jianqi Xue +25 more
doaj +1 more source
Application of Umbilical Cord Blood Stem Cells in Regenerative Medicine [PDF]
, 2014 BACKGROUND: Since the first umbilical cord blood (UCB) transplant, performed 25 years ago, UCB banks have been established worldwide for the collection and cryopreservation of UCB for autologous and allogeneic transplants.CONTENT: Much has been learned ...
Meiliana, A. (Anna), Wijaya, A. (Andi)
core +3 more sources
Hematopoietic stem cell mobilization
Haematologica, 2008 Recruitment of hematopoietic stem/progenitor cells (HSC) from the bone marrow into peripheral blood following treatment with chemotherapy and/or cytokines is termed mobilization. The release of HSC from the bone marrow is a physiological phenomenon for the protection of HSC from toxic injury ...
LEMOLI, ROBERTO MASSIMO, D'Addio A.
openaire +5 more sources
Clonal Dominance and Transplantation Dynamics in Hematopoietic Stem Cell Compartments [PDF]
PLoS Comput Biol 13(10): e1005803 (2017), 2017 Hematopoietic stem cells in mammals are known to reside mostly in the bone marrow, but also transitively passage in small numbers in the blood. Experimental findings have suggested that they exist in a dynamic equilibrium, continuously migrating between these two compartments.
arxiv +1 more source
Transient PP2A inhibition alleviates normal tissue stem cell susceptibility to cell death during radiotherapy [PDF]
, 2018 Unintended outcomes of cancer therapy include ionizing radiation (IR)-induced stem cell depletion, diminished regenerative capacity, and accelerated aging.
Fabbrizi, Maria Rita +6 more
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Hematopoietic stem cell transplantation
Stem Cells and Cloning: Advances and Applications, 2010 More than 25,000 hematopoietic stem cell transplantations (HSCTs) are performed each year for the treatment of lymphoma, leukemia, immune-deficiency illnesses, congenital metabolic defects, hemoglobinopathies, and myelodysplastic and myeloproliferative syndromes.
Mark Tuthill, Eleftheria Hatzimichael
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Dynamics of a Mathematical Hematopoietic Stem-Cell Population Model [PDF]
Journal on Applied Dynamical Systems, 18 (2019), 808-852, 2017 We explore the bifurcations and dynamics of a scalar differential equation with a single constant delay which models the population of human hematopoietic stem cells in the bone marrow. One parameter continuation reveals that with a delay of just a few days, stable periodic dynamics can be generated of all periods from about one week up to one decade ...
arxiv +1 more source
MGST1, a GSH transferase/peroxidase essential for development and hematopoietic stem cell differentiation. [PDF]
, 2018 We show for the first time that, in contrast to other glutathione transferases and peroxidases, deletion of microsomal glutathione transferase 1 (MGST1) in mice is embryonic lethal.
Abe, Hiroshi +10 more
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Hematopoietic stem cell metabolism and stemness
Blood Science, 2019 AbstractHematopoietic stem cells (HSCs) are considered to originate from the aorta-gonad-mesonephros, migrate into fetal liver for a rapid expansion, and eventually reside into a unique hypoxic bone marrow niche, where they maintain their homeostasis throughout their life span.
Chiqi Chen +4 more
openaire +4 more sources
Comparison of capacities to maintain hematopoietic stem cells among different types of stem cells derived from the placenta and umbilical cord [PDF]
, 2016 IntroductionCord blood is utilized as a useful source of cells for hematopoietic stem cell transplantation, but this can be problematic because there is a high rate of graft failure compared to when other graft sources are used.
Isige, Mika +5 more
core +1 more source