Results 41 to 50 of about 1,175,170 (409)

CREB is a critical regulator of normal hematopoiesis and leukemogenesis [PDF]

, 2008
The cAMP-responsive element binding protein (CREB) is a 43-kDa nuclear transcription factor that regulates cell growth, memory, and glucose homeostasis. We showed previously that CREB is amplified in myeloid leukemia blasts and expressed at higher levels
Akashi, Akashi, Bai, Bottazzi, Bruserud, Cheng, Christensen, Conkright, Crans-Vargas, Deepa B. Shankar, Dejah R. Judelson, Desdouets, Deshpande, Elliot M. Landaw, Fried, Fu, Hestdal, Impey, Ingrid Schmid, Jamieson, Jenny Chang, Jerry C. Cheng, Kathleen M. Sakamoto, Kentaro Kinjo, Kim, Kinjo, Kohn, Kondo, Koschmieder, Koya, Krishan, Kwon, Lee, Mayr, Mendoza, Miyoshi, Montminy, Ninomiya, Noriyuki Kasahara, Passegué, Ravi Bhatia, Rehemtulla, Renata Stripecke, Scherr, Shah, Shankar, Shankar, Shaywitz, Stripecke, Traver, Tuschl, Van Etten, Ventura, Winston S. Wu, Wong, Yuan   +55 more
core   +3 more sources

Hematopoietic Stem Cells and Their Roles in Tissue Regeneration

International Journal of Stem Cells, 2019
Hematopoietic stem cells (HSCs) are regarded as one of essential cell sources for treating regenerative diseases. Among many stem cells, the feasibility of using adult-derived hematopoietic stem cells in therapeutic approaches is very diverse, and is ...
Ji Yoon Lee, Seok-Ho Hong
semanticscholar   +1 more source

Zebrafish Caudal Haematopoietic Embryonic Stromal Tissue (CHEST) Cells Support Haematopoiesis. [PDF]

, 2017
Haematopoiesis is an essential process in early vertebrate development that occurs in different distinct spatial locations in the embryo that shift over time.
Aggio, Julian, Campbell, Clyde, Marquez, Gabriel, Stachura, David L, Traver, David, Wolf, Anja, Wright, Francis   +6 more
core   +1 more source

Regulation of stress-induced hematopoiesis [PDF]

, 2015
Purpose of review: Hematopoietic stem cells can self-renew and also give rise to the entire repertoire of hematopoietic cells. During acute infectious and inflammatory stresses, the hematopoietic system can quickly adapt to demand by increasing output of
Baltimore, David, Zhao, Jimmy L.
core   +1 more source

Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells

Genome Research, 2015
Both intrinsic cell state changes and variations in the composition of stem cell populations have been implicated as contributors to aging. We used single-cell RNA-seq to dissect variability in hematopoietic stem cell (HSC) and hematopoietic progenitor ...
Monika S. Kowalczyk, I. Tirosh, D. Heckl, T. N. Rao, Atray C Dixit, B. Haas, R. Schneider, A. Wagers, B. Ebert, A. Regev   +9 more
semanticscholar   +1 more source

Tianshengyuan-1 (TSY-1) regulates cellular Telomerase activity by methylation of TERT promoter. [PDF]

, 2016
Telomere and Telomerase have recently been explored as anti-aging and anti-cancer drug targets with only limited success. Previously we showed that the Chinese herbal medicine Tianshengyuan-1 (TSY-1), an agent used to treat bone marrow deficiency, has a ...
Chow, Michelle, Jin, Yusheng, Li, Yawei, Qin, Xiaotian, Rao, Jianyu, Santiskulvong, Chintda, Vu, Victor, Yu, Weibo, Zeng, Gang, Zhang, Zuofeng   +9 more
core   +2 more sources

Osteoblast Derived Exosomes Alleviate Radiation- Induced Hematopoietic Injury

Frontiers in Bioengineering and Biotechnology, 2022
As hematopoietic stem cells can differentiate into all hematopoietic lineages, mitigating the damage to hematopoietic stem cells is important for recovery from overdose radiation injury.
Jianqi Xue, Jianqi Xue, Ruikai Du, Shukuan Ling, Jinping Song, Xinxin Yuan, Caizhi Liu, Weijia Sun, Yuheng Li, Guohui Zhong, Yinbo Wang, Guodong Yuan, Xiaoyan Jin, Zizhong Liu, Dingsheng Zhao, Youyou Li, Wenjuan Xing, Yuanyuan Fan, Zifan Liu, Junjie Pan, Zhen Zhen, Yunzhang Zhao, Qinna Yang, Jianwei Li, Yan-Zhong Chang, Yingxian Li   +25 more
doaj   +1 more source

Mitochondrial Role in Stemness and Differentiation of Hematopoietic Stem Cells

Stem Cells International, 2019
Quiescent and self-renewing hematopoietic stem cells (HSCs) rely on glycolysis rather than on mitochondrial oxidative phosphorylation (OxPHOS) for energy production. HSC reliance on glycolysis is considered an adaptation to the hypoxic environment of the
Luena Papa, Mansour Djedaini, R. Hoffman
semanticscholar   +1 more source

The hematopoietic stem cell diet [PDF]

International Journal of Hematology, 2018
Hematopoietic stem cells (HSCs) are responsible for sustaining life-long blood formation or hematopoiesis and are also used clinically in a form of bone marrow transplantation, a curative cellular therapy for a range of hematological diseases. HSCs are maintained throughout adult life by a complex biological niche or microenvironment, which is thought ...
Adam C, Wilkinson, Satoshi, Yamazaki
openaire   +2 more sources

Inflamm-Aging of Hematopoiesis, Hematopoietic Stem Cells, and the Bone Marrow Microenvironment

Frontiers in Immunology, 2016
All hematopoietic and immune cells are continuously generated by hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs) through highly organized process of stepwise lineage commitment.
Larisa V. Kovtonyuk, K. Fritsch, Xiaomin Feng, M. Manz, Hitoshi Takizawa   +4 more
semanticscholar   +1 more source