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Application of Umbilical Cord Blood Stem Cells in Regenerative Medicine [PDF]
, 2014 BACKGROUND: Since the first umbilical cord blood (UCB) transplant, performed 25 years ago, UCB banks have been established worldwide for the collection and cryopreservation of UCB for autologous and allogeneic transplants.CONTENT: Much has been learned ...
Meiliana, A. (Anna), Wijaya, A. (Andi)
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Gene correction for SCID-X1 in long-term hematopoietic stem cells
Nature Communications, 2018 Gene correction in human long-term hematopoietic stem cells (LT-HSCs) could be an effective therapy for monogenic diseases of the blood and immune system.
Mara Pavel-Dinu +17 more
semanticscholar +1 more source
Adverse stem cell clones within a single patient’s tumor predict clinical outcome in AML patients
Journal of Hematology & Oncology, 2022 Acute myeloid leukemia (AML) patients suffer dismal prognosis upon treatment resistance. To study functional heterogeneity of resistance, we generated serially transplantable patient-derived xenograft (PDX) models from one patient with AML and twelve ...
Christina Zeller +11 more
doaj +1 more source
MGST1, a GSH transferase/peroxidase essential for development and hematopoietic stem cell differentiation. [PDF]
, 2018 We show for the first time that, in contrast to other glutathione transferases and peroxidases, deletion of microsomal glutathione transferase 1 (MGST1) in mice is embryonic lethal.
Abe, Hiroshi +10 more
core +3 more sources
Hematopoietic stem cell mobilization
Haematologica, 2008 Recruitment of hematopoietic stem/progenitor cells (HSC) from the bone marrow into peripheral blood following treatment with chemotherapy and/or cytokines is termed mobilization. The release of HSC from the bone marrow is a physiological phenomenon for the protection of HSC from toxic injury ...
LEMOLI, ROBERTO MASSIMO, D'Addio A.
openaire +5 more sources
Hematopoietic stem cell metabolism and stemness
Blood Science, 2019 AbstractHematopoietic stem cells (HSCs) are considered to originate from the aorta-gonad-mesonephros, migrate into fetal liver for a rapid expansion, and eventually reside into a unique hypoxic bone marrow niche, where they maintain their homeostasis throughout their life span.
Chiqi Chen +4 more
openaire +4 more sources
Hematopoietic stem cell transplantation
Stem Cells and Cloning: Advances and Applications, 2010 More than 25,000 hematopoietic stem cell transplantations (HSCTs) are performed each year for the treatment of lymphoma, leukemia, immune-deficiency illnesses, congenital metabolic defects, hemoglobinopathies, and myelodysplastic and myeloproliferative syndromes.
Mark Tuthill, Eleftheria Hatzimichael
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On Hematopoietic Stem Cell Fate [PDF]
Immunity, 2007 Multipotential hematopoietic stem cells (HSCs) maintain blood-cell formation throughout life. Here, Metcalf considers the origin and heterogeneity of HSCs, their ability to self-generate, and their commitment to the various hematopoietic lineages.
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Inflamm-Aging of Hematopoiesis, Hematopoietic Stem Cells, and the Bone Marrow Microenvironment
Frontiers in Immunology, 2016 All hematopoietic and immune cells are continuously generated by hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs) through highly organized process of stepwise lineage commitment.
Larisa V. Kovtonyuk +4 more
semanticscholar +1 more source
Hematopoietic stem cells for transplantation [PDF]
Nature Immunology, 2002 Multiple sources of HSCs exist. Here, Verfaillie discusses the long-term engraftment capabilities of each source and the search for ex vivo expansion conditions to allow bulk culture for therapeutic HSC transplantation.
openaire +4 more sources