Results 121 to 130 of about 428,654 (353)
Targeting heme in sickle cell disease: new perspectives on priapism treatment
Frontiers in PhysiologyMen with sickle cell disease (SCD) frequently experience priapism, defined as prolonged, painful erections occurring without sexual arousal or desire. This urological emergency can lead to penile fibrosis and permanent erectile dysfunction if not treated
Tammyris Helena Rebecchi Silveira +4 more
doaj +1 more source
Improvement of experimental testing and network training conditions with genome-wide microarrays for more accurate predictions of drug gene targets [PDF]
, 2014 BACKGROUND: Genome-wide microarrays have been useful for predicting chemical-genetic interactions at the gene level. However, interpreting genome-wide microarray results can be overwhelming due to the vast output of gene expression data combined with off-
Christadore, Lisa M. +3 more
core +1 more source
Heme as a Target for Therapeutic Interventions
Frontiers in Pharmacology, 2017 Heme is a complex of iron and the tetrapyrrole protoporphyrin IX with essential functions in aerobic organisms. Heme is the prosthetic group of hemoproteins such as hemoglobin and myoglobin, which are crucial for reversible oxygen binding and transport ...
S. Immenschuh +3 more
semanticscholar +1 more source
Advanced Science, EarlyView.This study develops gallium‐doped V2C MXene nanozymes (Ga‐V2C) to treat acetaminophen‐induced liver injury through multi‐death pathway blockade and hepatocyte regeneration. Unlike conventional single‐target therapies like N‐acetylcysteine, Ga‐V2C nanozymes enable oxidative stress suppression, apoptosis, and ferroptosis inhibition, and enhanced ...
Xiaopeng Cai +13 more
wiley +1 more source
Enhanced production of thermostable catalase for efficient gluconic acid biocatalysis
Frontiers in Sustainable Food SystemsIntroductionThe demand for gluconic acid (GA) has risen recently, driven by its extensive applications in the food, healthcare, and construction industries.
Jiang Huang +15 more
doaj +1 more source
Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth
Advanced Science, EarlyView.Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang +12 more
wiley +1 more source
A pH Dependant Switch in DHP Oxidation Mechanism [PDF]
, 2017 Dehaloperoxidase (DHP) is a multifunctional enzyme found in Amphitrite ornata, a sediment-dwelling marine worm. This enzyme possess the structure of a traditional hemoglobin enzyme and serves as the primary oxygen carrier in A.
Fehr, Travis
core +1 more source
, 2011 Nitrogen-doped carbon nanotubes can provide reactive sites on the porphyrin-like defects. It's well known that many porphyrins have transition metal atoms, and we have explored transition metal atoms bonded to those porphyrin-like defects in N-doped ...
da Silva, A. J. R. +3 more
core +1 more source
Oxidative stress is tightly regulated by cytochrome c phosphorylation and respirasome factors in mitochondria [PDF]
, 2018 Respiratory cytochrome c has been found to be phosphorylated at tyrosine 97 in the postischemic brain upon neuroprotective insulin treatment, but how such posttranslational modification affects mitochondrial metabolism is unclear.
Díaz Moreno, Irene +7 more
core +1 more source
PPE Surface Proteins Are Required for Heme Utilization by Mycobacterium tuberculosis
mBio, 2017 Iron is essential for replication of Mycobacterium tuberculosis, but iron is efficiently sequestered in the human host during infection. Heme constitutes the largest iron reservoir in the human body and is utilized by many bacterial pathogens as an iron ...
Avishek Mitra +4 more
semanticscholar +1 more source