Results 121 to 130 of about 339,218 (339)

Pseudomonas Cytochrome c551 at 2.0 angstrom Resolution: Enlargement of the Cytochrome c Family [PDF]

, 1978
The structure of respiratory cytochrome c551 of Pseudomonas aeruginosa, with 82 amino acids, has been solved by x-ray analysis and refined to a crystallographic R factor of 16.2%.
Almassy, Robert J., Dickerson, Richard E.   +1 more
core  

Electrochemical titrations and reaction time courses monitored in situ by magnetic circular dichroism spectroscopy [PDF]

, 2011
Magnetic circular dichroism (MCD) spectra, at ultraviolet–visible or near-infrared wavelengths (185–2000 nm), contain the same transitions observed in conventional absorbance spectroscopy, but their bisignate nature and more stringent selection rules ...
Abramson, Allen, Armstrong, Cheesman, Cheesman, Cheesman, Cheesman, Craft, Dooley, Duin, Farrar, Field, Fulop, Gadsby, Gamelin, Gates, George, Hadler, Horio, Hänzelmann, Johnson, Johnson, Johnson, Jones, Julea N. Butt, Justin M. Bradley, Kemp, Kobayashi, Koppenhofer, Larrabee, Male, Marritt, Marritt, Mitić, Mitou, Moir, Myles R. Cheesman, Paes de Sousa, Pauleta, Quintanar, Rasmussen, Richter, Rupnik, Simon, Solomon, Solomon, Solomon, Suharti, Thomson, Thomson, van Gelder, Vickery, Walters   +52 more
core   +1 more source

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

Engineering tyrosine-based electron flow pathways in proteins: The case of aplysia myoglobin [PDF]

, 2012
Tyrosine residues can act as redox cofactors that provide an electron transfer ("hole-hopping") route that enhances the rate of ferryl heme iron reduction by externally added reductants, for example, ascorbate.
Alayash A. I., Alayash A. I., Aubert C., Bolognesi M., Brandon J. Reeder, Chris E. Cooper, Dimitri A. Svistunenko, Egmond M. R., Ekberg M., Ekberg M., Gray H. B., Holt S., Lardinois O. M., McLeod L. L., Michael T. Wilson, Moore K. P., Natanson C., Nilges M. J., Peisach J., Reece S. Y., Reeder B. J., Reeder B. J., Reeder B. J., Reeder B. J., Reeder B. J., Reeder B. J., Reeder B. J., Rogers M. S., Rova U., Rova U., Seyedsayamdost M. R., Shih C., Silaghi-Dumitrescu R., Stubbe J., Svistunenko D. A., Svistunenko D. A., Svistunenko D. A., Thompson M. K., Wilbur D. J., Yee C. S.   +39 more
core   +1 more source

Elevated Histone Lactylation Mediates Ferroptosis Resistance in Endometriosis Through the METTL3‐Regulated HIF1A/HMOX1 Signaling Pathway

Advanced Science, EarlyView.
This study reveals that histone lactylation, a modification derived from lactate, plays a crucial role in ferroptosis resistance in ectopic endometrial stromal cells. This resistance is mediated via the HIF1A/HMOX1 pathway regulated by METTL3. In vivo, a combination of 2‐DG and erastin shows promise as an effective treatment for endometriosis ...
Zongwen Liang, Jinming Liu, Yanling Gou, Honglin Wang, Zhi Li, Yingying Cao, Huiyan Zhang, Ruru Bai, Zongfeng Zhang   +8 more
wiley   +1 more source

An investigation into the feasibility of myoglobin-based single-electron transistors

, 2012
Myoglobin single-electron transistors were investigated using nanometer- gap platinum electrodes fabricated by electromigration at cryogenic temperatures. Apomyoglobin (myoglobin without heme group) was used as a reference.
Bendall D S, David Lederman, Debin Li, Dong J, Garrett R H, Hayashi T, Li D, Park J, Peter M Gannett, Spiro T G   +9 more
core   +1 more source

Probing a Complex of Cytochromecand Cardiolipin by Magnetic Circular Dichroism Spectroscopy: Implications for the Initial Events in Apoptosis [PDF]

, 2011
Oxidation of cardiolipin (CL) by its complex with cytochrome c (cyt c) plays a crucial role in triggering apoptosis. Through a combination of magnetic circular dichroism spectroscopy and potentiometric titrations, we show that both the ferric and ferrous
Armstrong F. A., Barker P. D., Basova L. V., Battistuzzi G., Battistuzzi G., Belikova N. A., Belikova N. A., Bradley J. M., Bushnell G. W., Cheesman M. R., Cheesman M. R., Ferrer J. C., Foote N., Gadsby P. M. A., Gadsby P. M. A., Gary Silkstone, Hendriks J. H. M., Jing W. G., Julea N. Butt, Justin M. Bradley, Kagan V. E., Kagan V. E., Kalanxhi E., Kapetanaki S. M., Kapralov A. A., Marritt S. J., Michael T. Wilson, Millis K. K., Myles R. Cheesman, Nantes I. L., Oganesyan V. S., Petrovic J., Pettigrew G. W., Pond A. E., Rawlings J., Rigby S. E. J., Rytomaa M., Salamon Z., Sinibaldi F., Sutherland J., Tezcan F. A., Wackerbarth H., Zucchi M. R.   +42 more
core   +1 more source

Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy

Advanced Science, EarlyView.
In ARHL, the stria vascularis, acting as a cochlear battery, gradually loses its ability to maintain the endocochlear potential, leading to impaired hair cell function and progressive hearing loss. Single‐cell sequencing reveals age‐related cellular changes in the cochlea, providing insights into the underlying mechanisms of aging and potential ...
Xiaoxu Zhao, Tian Shen, Shengda Cao, Ziyi Liu, Wendu Pang, Meixuan Li, Jingjing Liu, Wen Li, Yunhao Wu, Chengcheng Liu, Ming Xia, Xiaolong Fu, Cheng Cheng   +12 more
wiley   +1 more source

Recent insights into the biological functions of liver fatty acid binding protein 1

Journal of Lipid Research, 2015
Over four decades have passed since liver fatty acid binding protein (FABP)1 was first isolated. There are few protein families for which most of the complete tertiary structures, binding properties, and tissue occurrences are described in such detail ...
GuQi Wang, Herbert L. Bonkovsky, Andrew de Lemos, Frank J. Burczynski   +3 more
doaj  

Vitamin Interrelationships in Heme Synthesis [PDF]

, 1959
Dan A. Richert, Martin P. Schulman
openalex   +1 more source