Light-induced depigmentation in planarians models the pathophysiology of acute porphyrias
eLife, 2016 Porphyrias are disorders of heme metabolism frequently characterized by extreme photosensitivity. This symptom results from accumulation of porphyrins, tetrapyrrole intermediates in heme biosynthesis that generate reactive oxygen species when exposed to ...
Bradford M Stubenhaus +8 more
doaj +1 more source
A New Role for Heme, Facilitating Release of Iron from the Bacterioferritin Iron Biomineral [PDF]
, 2010 Samina Yasmin +3 more
openalex +1 more source
Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death
OncoTarget, 2015 The oncogenic RAS-selective lethal small molecule Erastin triggers a unique iron-dependent form of nonapoptotic cell death termed ferroptosis. Ferroptosis is dependent upon the production of intracellular iron-dependent reactive oxygen species (ROS), but
Min‐Young Kwon +3 more
semanticscholar +1 more source
Bioinspired Tissue Transparency: Achieving Sclera‐to‐Cornea Transplantation
Advanced Science, EarlyView.A bioinspired decellularization‐compression‐locking tactic (DCLT) is developed to transform human sclerae into transparent corneal substitutes. These clear, robust, and pro‐regenerative substitutes are capable of repairing complex corneal injuries, including chemical burns, keratoconus, and penetrating wounds, demonstrating their clinical potential to ...
Xiuli Sun +8 more
wiley +1 more source
Quantification of labile heme in live malaria parasites using a genetically encoded biosensor
Proceedings of the National Academy of Sciences of the United States of America, 2017 Significance Malaria parasites degrade substantial quantities of hemoglobin to release heme within a specialized digestive vacuole. Most of this heme is sequestered in an inert crystal.
James R. Abshire +4 more
semanticscholar +1 more source
Advanced Science, EarlyView.Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang +7 more
wiley +1 more source
Characterization of plasma labile heme in hemolytic conditions
The FEBS Journal, 2017 Extracellular hemoglobin, a byproduct of hemolysis, can release its prosthetic heme groups upon oxidation. This produces metabolically active heme that is exchangeable between acceptor proteins, macromolecules and low molecular weight ligands, termed ...
Zelia Gouveia +14 more
semanticscholar +1 more source
Advanced Science, EarlyView.A redox‐active conductive carrier of tannic acid‐modified iron‐biochar with superior wettability is demonstrated to regulate direct electron transfer at the anaerobic biofilm‐carrier interface by enhancing the cytochrome c‐mediated pathway. For the first time, integrated evidence from spectroscopy, electrochemical analyses, and metatranscriptomics ...
Junli Tian +5 more
wiley +1 more source
Vascular Smooth Muscle Cell–Directed Overexpression of Heme Oxygenase-1 Elevates Blood Pressure Through Attenuation of Nitric Oxide–Induced Vasodilation in Mice [PDF]
, 2001 T. Imai +7 more
openalex +1 more source
Heme dynamics and trafficking factors revealed by genetically encoded fluorescent heme sensors
Proceedings of the National Academy of Sciences of the United States of America, 2016 Significance All heme-dependent functions require the mobilization of labile heme (LH), of which there is little understanding of its nature and dynamics.
David A. Hanna +8 more
semanticscholar +1 more source