Results 161 to 170 of about 428,654 (353)

Precision‐Engineered Silver Single‐Atom Carbon Dot Nanozymes for Theranostic Management of Acute Kidney Injury

Advanced Science, EarlyView.
Mitochondria‐targeted silver single‐atom carbon dot (T‐AgSA‐CDs) nanozymes enable dual SOD/GPx‐like ROS scavenging, real‐time imaging, and therapeutic effects for acute kidney injury (AKI). Atomically dispersed Ag sites synergize with carbon dots to restore renal redox hemostasis, protect mitochondrial function, mitigate inflammation, facilitate post ...
Tianle Tang, Jun Zhang, Yan Wang, Guoping Chen, Kehui Yuan, Yuan He, Chenchen Li, Sumaira Hanif, Yang Yang, Yanli Wang, Pir Muhammad   +10 more
wiley   +1 more source

Atomistic Simulations of Heme Dissociation Pathways in Human Methemoglobins Reveal Hidden Intermediates

, 2020
Premila P. Samuel, David A. Case
openalex   +2 more sources

Cytochrome C6 of Chlamydomonas Reinhardtii - A Heme Protein with Unusual Properties [PDF]

, 2012
Nicole Lynn Vanderbush, Brian St. Clair, Marilyn Davis, Dan J. Davis   +3 more
openalex   +1 more source

From Solution to Surface: How the Catalytic Environment Modulates Peptide Bond Cleavage by Metal‐Oxo Cluster Nanozymes

Advanced Science, EarlyView.
Comparison of homogeneous Hf12(sol) and heterogeneous Hf12(precip) metal‐oxo clusters enables investigation of how solubility influences nanozymatic reactivity and selectivity toward proteolysis, without introducing confounding factors from differences in cluster identity.
Kilian Declerck, Muhammed Jibin Parammal, Carlotta Seno, Thomas J. N. Hooper, Dimitrios Sakellariou, Jonathan De Roo, Nada D. Savić, Tatjana N. Parac‐Vogt   +7 more
wiley   +1 more source

Charged Amino Acid Substitutions Affect Conformation of Neuroglobin and Cytochrome c Heme Groups

Current Issues in Molecular Biology
Neuroglobin (Ngb) is a cytosolic heme protein that plays an important role in protecting cells from apoptosis through interaction with oxidized cytochrome c (Cyt c) released from mitochondria.
Marina A. Semenova, Zhanna V. Bochkova, Olga M. Smirnova, Georgy V. Maksimov, Mikhail P. Kirpichnikov, Dmitry A. Dolgikh, Nadezda A. Brazhe, Rita V. Chertkova   +7 more
doaj   +1 more source

Crystallization of heme dioxygenases IDO and TDO facilitates structure-based design of cancer immunology therapeutics [PDF]

, 2020
Angela Oh
openalex   +1 more source

Development and atomic structure of a new fluorescence-based sensor to probe heme transfer in bacterial pathogens [PDF]

, 2023
Brendan J. Mahoney, Andrew K. Goring, Yueying Wang, Poojita Dasika, Anqi Zhou, Emmitt Grossbard, Duilio Cascio, Joseph A. Loo, Robert Clubb   +8 more
openalex   +1 more source

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source

Microglial Membranes Wrapped Ultrasmall Medium‐Entropy Ru Single‐Atom Nanozyme: Enhanced Catalysis for Accelerating Inflammation/Redox Microenvironment Regulation in Intracerebral Hemorrhage

Advanced Science, EarlyView.
PtRhIr/Ru SAN@M nanozymes cross the blood–brain barrier and selectively accumulate in hemorrhagic brain regions. By mimicking multiple enzyme activities, they attenuate oxidative stress, modulate microglial polarization toward an anti‐inflammatory phenotype, inhibit ferroptosis, and promote neuronal repair.
Jiebo Li, Penghui Wei, Yuanbo Pan, Hongjia Zheng, Jiajun Hu, Qianxi Chen, Zhongyuan Shen, Yongrui Hu, Jiajun Wu, Fuxin Lin, Fuxiang Chen, Chenyu Ding, Wenhua Fang, Yuanxiang Lin, Dezhi Kang, Yuxiang Gu, Yang Zhu, Dengliang Wang   +17 more
wiley   +1 more source

Regulation of heme biosynthesis via the coproporphyrin dependent pathway in bacteria

Frontiers in Microbiology
Heme biosynthesis in the Gram-positive bacteria occurs mostly via a pathway that is distinct from that of eukaryotes and Gram-negative bacteria in the three terminal heme synthesis steps.
Hadia Aftab, Rebecca K. Donegan
doaj   +1 more source