Results 51 to 60 of about 428,654 (353)

Mortality from different causes associated with meat, heme iron, nitrates, and nitrites in the NIH-AARP Diet and Health Study: population based cohort study

British medical journal, 2017
Objective To determine the association of different types of meat intake and meat associated compounds with overall and cause specific mortality. Design Population based cohort study.
A. Etemadi, R. Sinha, M. Ward, B. Graubard, Maki Inoue-Choi, S. Dawsey, C. Abnet   +6 more
semanticscholar   +1 more source

Import of cytochrome c into mitochondria [PDF]

, 1987
The import of cytochrome c into mitochondria can be resolved into a number of discrete steps. Here we report on the covalent attachment of heme to apocytochrome c by the enzyme cytochrome c heme lyase in mitochondria from Neurospora crassa. A new method
Basile G., Burnette W. N., Chance B., Dumont M. E., Ernst V., Estabrook R. W., Freitag H., Gasser S. M., Hackenbrock C. R., Hay R., Heller J., Hennig B., Hennig B., Hennig B., Kanarek L., Korb H., Laemmli U. K., Lederer F., Matner R. R., Matsuura S., Means G. E., Mihara K., Nicholson D. W., Nozaki M., Pelham H. R. B., Rietveld A., Rietveld A., Rietveld A., Rietveld A., Scarpulla R. C., Schmidt B., Sherman F., Stewart J. W., Taniuchi H., Taniuchi H., Towbin H., Veloso D., Visco C., Yuan P.-M., Zimmermann R., Zimmermann R., Zimmermann R., Zitomer R. S.   +42 more
core   +1 more source

Discovering How Heme Controls Genome Function Through Heme-omics

Cell Reports, 2020
Summary: Protein ensembles control genome function by establishing, maintaining, and deconstructing cell-type-specific chromosomal landscapes. A plethora of small molecules orchestrate cellular functions and therefore may link physiological processes ...
Ruiqi Liao, Ye Zheng, Xin Liu, Yuannyu Zhang, Gretchen Seim, Nobuyuki Tanimura, Gary M. Wilson, Peiman Hematti, Joshua J. Coon, Jing Fan, Jian Xu, Sunduz Keles, Emery H. Bresnick   +12 more
doaj   +1 more source

Endothelial TLR4 Expression Mediates Vaso-Occlusive Crisis in Sickle Cell Disease

Frontiers in Immunology, 2021
Heme, released from red blood cells in sickle cell disease (SCD), interacts with toll-like receptor 4 (TLR4) to activate NF-κB leading to the production of cytokines and adhesion molecules which promote inflammation, pain, and vaso-occlusion.
Joan D. Beckman, Fuad Abdullah, Chunsheng Chen, Rachel Kirchner, Dormarie Rivera-Rodriguez, Zachary M. Kiser, Aithanh Nguyen, Ping Zhang, Julia Nguyen, Robert P. Hebbel, John D. Belcher, Gregory M. Vercellotti   +11 more
doaj   +1 more source

Human Heme Oxygenase Oxidation of 5- and 15-Phenylhemes [PDF]

, 2004
Human heme oxygenase-1 (hHO-1) catalyzes the O2- dependent oxidation of heme to biliverdin, CO, and free iron. Previous work indicated that electrophilic addition of the terminal oxygen of the ferric hydroperoxo complex to the -meso-carbon gives 5 ...
Alvarez, Diego Ezequiel, Buldain, Graciela Yolanda, Huang, Liusheng, Lad, Latesh, Niemevz, Fernando, Ortiz de Montellano, Paul R., Poulos, Thomas L., Wang, Jingling   +7 more
core   +1 more source

Heme Uptake and Utilization by Gram-Negative Bacterial Pathogens

Frontiers in Cellular and Infection Microbiology, 2019
Iron is a transition metal utilized by nearly all forms of life for essential cellular processes, such as DNA synthesis and cellular respiration. During infection by bacterial pathogens, the host utilizes various strategies to sequester iron in a process
Kaylie L. Richard, Brittni R Kelley, Jeremiah G. Johnson   +2 more
semanticscholar   +1 more source

The molecular and cellular action properties of artemisinins: what has yeast told us?

Microbial Cell, 2016
Artemisinin (ART) or Qinghaosu is a natural compound possessing superior anti-malarial activity. Although intensive studies have been done in the medicinal chemistry field to understand the structure-effect relationship, the biological actions of ...
Chen Sun, Bing Zhou
doaj   +1 more source

Biogenesis of mitochondrial c-type cytochromes [PDF]

, 1990
Cytochromesc andc 1 are essential components of the mitochondrial respiratory chain. In both cytochromes the heme group is covalently linked to the polypeptide chain via thioether bridges. The location of the two cytochromes is in the intermembrane space;
Gonzales, Daniel H., Neupert, Walter
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Effects of Bodypump Training on Blood Pressure and Physical Fitness in Sedentary Older Adults with Hypertension: A Randomized Trial

Physiologia
Background/Objectives: Hypertension is a leading cause of cardiovascular morbidity and mortality, particularly in older adults, pharmacological therapy is effective, but side effects and limited adherence highlight the need for non-pharmacological ...
Manuel Jesús Rodríguez Chavarría, Manuel Chavarrías-Olmedo, Jorge Pérez-Gómez   +2 more
doaj   +1 more source