Results 61 to 70 of about 414,309 (352)
The macrophage heme-heme oxygenase-1 system and its role in inflammation.
Biochemical Pharmacology, 2018 Heme oxygenase (HO)-1, the inducible isoform of the heme-degrading enzyme HO, plays a critical role in inflammation and iron homeostasis. Regulatory functions of HO-1 are mediated via the catalytic breakdown of heme, which is an iron-containing ...
Vijith Vijayan +2 more
semanticscholar +1 more source
Maturation of Plastid c-type Cytochromes
Frontiers in Plant Science, 2017 Cytochromes c are hemoproteins, with the prosthetic group covalently linked to the apoprotein, which function as electron carriers. A class of cytochromes c is defined by a CXXCH heme-binding motif where the cysteines form thioether bonds with the vinyl ...
Stéphane T. Gabilly +3 more
doaj +1 more source
Endothelial TLR4 Expression Mediates Vaso-Occlusive Crisis in Sickle Cell Disease
Frontiers in Immunology, 2021 Heme, released from red blood cells in sickle cell disease (SCD), interacts with toll-like receptor 4 (TLR4) to activate NF-κB leading to the production of cytokines and adhesion molecules which promote inflammation, pain, and vaso-occlusion.
Joan D. Beckman +11 more
doaj +1 more source
Human Heme Oxygenase Oxidation of 5- and 15-Phenylhemes [PDF]
, 2004 Human heme oxygenase-1 (hHO-1) catalyzes the O2- dependent oxidation of heme to biliverdin, CO, and free iron. Previous work indicated that electrophilic addition of the terminal oxygen of the ferric hydroperoxo complex to the -meso-carbon gives 5 ...
Alvarez, Diego Ezequiel +7 more
core +1 more source
Handling heme: The mechanisms underlying the movement of heme within and between cells
Free Radical Biology & Medicine, 2019 Heme is an essential cofactor and signaling molecule required for virtually all aerobic life. However, excess heme is cytotoxic. Therefore, heme must be safely transported and trafficked from the site of synthesis in the mitochondria or uptake at the ...
Rebecca K. Donegan +3 more
semanticscholar +1 more source
Frontiers in Cellular and Infection Microbiology, 2018 Malaria is a serious disease and was responsible for 429,000 deaths in 2015. Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is one of the main clinical complications of severe malaria; it is characterized by a high mortality rate and ...
Marcelo L. M. Pereira +2 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Heme Uptake and Utilization by Gram-Negative Bacterial Pathogens
Frontiers in Cellular and Infection Microbiology, 2019 Iron is a transition metal utilized by nearly all forms of life for essential cellular processes, such as DNA synthesis and cellular respiration. During infection by bacterial pathogens, the host utilizes various strategies to sequester iron in a process
Kaylie L. Richard +2 more
semanticscholar +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source