Results 61 to 70 of about 339,218 (339)

Interaction of class III cellobiose dehydrogenase with lytic polysaccharide monooxygenase

FEBS Open Bio, EarlyView.
The activity of lytic polysaccharide monooxygenase (LPMO) is supported by its auxiliary enzyme cellobiose dehydrogenase (CDH). The catalytic activity of both enzymes is coupled by electron transfer and a cyclic cascade generating substrates for both enzymes – hydrogen peroxide for LPMO and oxidized and non‐oxidized cellobiose and cello‐oligosaccharide ...
Angela Giorgianni, Florian Csarman, Peicheng Sun, Mirjam Kabel, Roland Ludwig   +4 more
wiley   +1 more source

Biogenesis of cytochrome c1 [PDF]

, 1989
The biogenesis of cytochrome c1 involves a number of steps including: synthesis as a precursor with a bipartite signal sequence, transfer across the outer and inner mitochondrial membranes, removal of the first part of the presequence in the matrix ...
Neupert, Walter, Nicholson, Donald W., Stuart, Rosemary A.   +2 more
core  

Amino Acid Substitutions in the Non-Ordered Ω-Loop 70–85 Affect Electron Transfer Function and Secondary Structure of Mitochondrial Cytochrome c

Crystals, 2021
The secondary structure of horse cytochrome c with mutations in the P76GTKMIFA83 site of the Ω-loop, exhibiting reduced efficiency of electron transfer, were studied.
Rita V. Chertkova, Tatyana V. Bryantseva, Nadezhda A. Brazhe, Kseniya S. Kudryashova, Victor V. Revin, Alexei N. Nekrasov, Alexander I. Yusipovich, Alexey R. Brazhe, Andrew B. Rubin, Dmitry A. Dolgikh, Mikhail P. Kirpichnikov, Georgy V. Maksimov   +11 more
doaj   +1 more source

Polydatin ameliorates ovalbumin‐induced asthma in a rat model through NCOA4‐mediated ferroautophagy and ferroptosis pathway

FEBS Open Bio, EarlyView.
In this research, a rat model of asthma was created using OVA, and polydatin served as an intervention. By inhibiting ferroautophagy mediated by NCOA4 and averting ferroptosis, polydatin has been demonstrated to reduce asthma. This work presents new ideas for investigating the mechanism of polydatin's ability to alleviate asthma, in addition to ...
Wei Li, Yuwei Tang, Wenkang Liu, Fang Fang, Jiepeng Wang, Chaoyi Fang   +5 more
wiley   +1 more source

A Transcriptomic Approach to the Metabolism of Tetrapyrrolic Photosensitizers in a Marine Annelid

Molecules, 2021
The past decade has seen growing interest in marine natural pigments for biotechnological applications. One of the most abundant classes of biological pigments is the tetrapyrroles, which are prized targets due their photodynamic properties; porphyrins ...
Maria Leonor Santos, Mariaelena D’Ambrosio, Ana P. Rodrigo, A. Jorge Parola, Pedro M. Costa   +4 more
doaj   +1 more source

Hemoglobin and heme scavenging [PDF]

IUBMB Life (International Union of Biochemistry and Molecular Biology: Life), 2005
Release of hemoglobin into plasma is a physiological phenomenon associated with intravascular hemolysis. In plasma, stable haptoglobin-hemoglobin complexes are formed and these are subsequently delivered to the reticulo-endothelial system by CD163 receptor-mediated endocytosis.
ASCENZI P, BOCEDI A, VISCA P, ALTRUDA, Fiorella, TOLOSANO, Emanuela, BERINGHELLI T, FASANO M.   +6 more
openaire   +6 more sources

BCS1L‐Associated Disease: 5′‐UTR Variant Shifts the Phenotype Towards Axonal Neuropathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To investigate the consequences of a pathogenic missense variant (c.838C>T; p.L280F) and a 5′‐UTR regulatory variant (c.‐122G>T) in BCS1L on disease pathogenesis and to understand how regulatory variants influence disease severity and clinical presentation.
Rotem Orbach, Nunziata Maio, Russell J. Butterfield, A. Reghan Foley, Sarah Silverstein, Yan Li, Katherine Chao, Tanya J. Lehky, Abigail Potticary, Tracey A. Rouault, Sandra Donkervoort, Carsten G. Bönnemann   +11 more
wiley   +1 more source

Human Heme Oxygenase Oxidation of 5- and 15-Phenylhemes [PDF]

, 2004
Human heme oxygenase-1 (hHO-1) catalyzes the O2- dependent oxidation of heme to biliverdin, CO, and free iron. Previous work indicated that electrophilic addition of the terminal oxygen of the ferric hydroperoxo complex to the -meso-carbon gives 5 ...
Alvarez, Diego Ezequiel, Buldain, Graciela Yolanda, Huang, Liusheng, Lad, Latesh, Niemevz, Fernando, Ortiz de Montellano, Paul R., Poulos, Thomas L., Wang, Jingling   +7 more
core   +1 more source

Silencing of Iron and Heme-Related Genes Revealed a Paramount Role of Iron in the Physiology of the Hematophagous Vector Rhodnius prolixus

Frontiers in Genetics, 2018
Iron is an essential element for most organisms However, free iron and heme, its complex with protoporphyrin IX, can be extremely cytotoxic, due to the production of reactive oxygen species, eventually leading to oxidative stress.
Ana B. Walter-Nuno, Ana B. Walter-Nuno, Mabel L. Taracena, Mabel L. Taracena, Rafael D. Mesquita, Rafael D. Mesquita, Pedro L. Oliveira, Pedro L. Oliveira, Gabriela O. Paiva-Silva, Gabriela O. Paiva-Silva   +9 more
doaj   +1 more source

The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang, Yuanyuan Xue, Lei Chang, Xuena Zhu, Wenjun Liu, Tingbo Liang   +5 more
wiley   +1 more source