Results 1 to 10 of about 133,546 (124)
Antioxidants, 2022 The heme oxygenase (HO) enzyme system catabolizes heme to carbon monoxide (CO), ferrous iron, and biliverdin-IXα (BV), which is reduced to bilirubin-IXα (BR) by biliverdin reductase (BVR).
S. Ryter
semanticscholar +1 more source
Heme Oxygenase-1 Signaling and Redox Homeostasis in Physiopathological Conditions
Biomolecules, 2021 Heme-oxygenase is the enzyme responsible for degradation of endogenous iron protoporphyirin heme; it catalyzes the reaction’s rate-limiting step, resulting in the release of carbon monoxide (CO), ferrous ions, and biliverdin (BV), which is successively ...
Valeria Consoli +3 more
semanticscholar +1 more source
Blood, 2021 Sickle cell disease (SCD) is characterized by increased hemolysis which results in plasma heme overload and ultimately cardiovascular complications. Here, we hypothesized that increased heme in SCD causes upregulation of heme oxygenase 1 (Hmox1) which ...
Archita V. Menon +6 more
semanticscholar +1 more source
The Diverse Roles of Heme Oxygenase-1 in Tumor Progression
Frontiers in Immunology, 2021 Heme oxygenase-1 (HO-1) is an inducible intracellular enzyme that is expressed in response to a variety of stimuli to degrade heme, which generates the biologically active catabolites carbon monoxide (CO), biliverdin and ferrous iron (Fe2+).
Kim Ngan Luu Hoang +2 more
semanticscholar +1 more source
On a class of Hessian type equations on Riemannian manifolds [PDF]
Proceedings of the American Mathematical Society, 2021, 2022 In this paper, we consider a class of Hessian type equations which include the $(n-1)$ Monge-Amp\`{e}re equation on Riemannian manifolds. The \emph{a priori} $C^2$ estimates and the existence of solutions are established.
arxiv +1 more source
Antioxidants, 2020 SARS-CoV-2 is causing a pandemic resulting in high morbidity and mortality. COVID-19 patients suffering from acute respiratory distress syndrome (ARDS) are often critically ill and show lung injury and hemolysis.
F. Wagener +4 more
semanticscholar +1 more source
Fabrication of electronically conductive protein-heme nanowires for power harvesting [PDF]
Small, 2024, 2311661, 2023 Electronically conductive protein-based materials could enable the creation of bioelectronic components and devices from sustainable and nontoxic materials, while also being well-suited to interface with biological systems, such as living cells, for biosensor applications.
arxiv +1 more source
A Dual Role of Heme Oxygenase-1 in Cancer Cells
International Journal of Molecular Sciences, 2018 Heme oxygenase (HO)-1 is known to metabolize heme into biliverdin/bilirubin, carbon monoxide, and ferrous iron, and it has been suggested to demonstrate cytoprotective effects against various stress-related conditions.
Shih-Kai Chiang +2 more
semanticscholar +1 more source
Heme oxygenase-1 mitigates ferroptosis in renal proximal tubule cells.
AJP - Renal Physiology, 2018 Ferroptosis is an iron-dependent form of regulated nonapoptotic cell death, which contributes to damage in models of acute kidney injury (AKI). Heme oxygenase-1 (HO-1) is a cytoprotective enzyme induced in response to cellular stress, and is protective ...
Oreoluwa O. Adedoyin +6 more
semanticscholar +1 more source
Role of Heme Oxygenase as a Modulator of Heme-Mediated Pathways
Antioxidants, 2019 The heme oxygenase (HO) system is essential for heme and iron homeostasis and necessary for adaptation to cell stress. HO degrades heme to biliverdin (BV), carbon monoxide (CO) and ferrous iron.
J. Duvigneau +2 more
semanticscholar +1 more source