Results 1 to 10 of about 161,635 (252)

Heme oxygenase-1 deficiency alters erythroblastic island formation, steady-state erythropoiesis and red blood cell lifespan in mice

Haematologica, 2015
Heme oxygenase-1 is critical for iron recycling during red blood cell turnover, whereas its impact on steady-state erythropoiesis and red blood cell lifespan is not known. We show here that in 8- to 14-week old mice, heme oxygenase-1 deficiency adversely
Stuart T. Fraser, Robyn G. Midwinter, Lucy A. Coupland, Stephanie Kong, Birgit S. Berger, Jia Hao Yeo, Osvaldo Cooley Andrade, Deborah Cromer, Cacang Suarna, Magda Lam, Ghassan J. Maghzal, Beng H. Chong, Christopher R. Parish, Roland Stocker   +13 more
doaj   +2 more sources

Editorial: The heme oxygenase system in immunity [PDF]

Frontiers in Immunology
Diego L. Costa, Emanuela M. Bruscia, Dean Willis   +2 more
doaj   +2 more sources

Heme Oxygenase-1: An Anti-Inflammatory Effector in Cardiovascular, Lung, and Related Metabolic Disorders

Antioxidants, 2022
The heme oxygenase (HO) enzyme system catabolizes heme to carbon monoxide (CO), ferrous iron, and biliverdin-IXα (BV), which is reduced to bilirubin-IXα (BR) by biliverdin reductase (BVR).
S. Ryter
semanticscholar   +1 more source

Heme Oxygenase-1 Signaling and Redox Homeostasis in Physiopathological Conditions

Biomolecules, 2021
Heme-oxygenase is the enzyme responsible for degradation of endogenous iron protoporphyirin heme; it catalyzes the reaction’s rate-limiting step, resulting in the release of carbon monoxide (CO), ferrous ions, and biliverdin (BV), which is successively ...
Valeria Consoli, V. Sorrenti, Salvo Grosso, L. Vanella   +3 more
semanticscholar   +1 more source

Excess heme upregulates heme oxygenase 1 and promotes cardiac ferroptosis in mice with sickle cell disease.

Blood, 2021
Sickle cell disease (SCD) is characterized by increased hemolysis which results in plasma heme overload and ultimately cardiovascular complications. Here, we hypothesized that increased heme in SCD causes upregulation of heme oxygenase 1 (Hmox1) which ...
Archita V. Menon, Jing Liu, H. Tsai, Lin Zeng, Seungjeong Yang, A. Asnani, Jonghan Kim   +6 more
semanticscholar   +1 more source

Roles of Heme Oxygenase-1 in Neuroinflammation and Brain Disorders

Antioxidants, 2022
The heme oxygenase (HO) system is believed to be a crucial mechanism for the nervous system under stress conditions. HO degrades heme to carbon monoxide, iron, and biliverdin.
Yi‐Hsuan Wu, H. Hsieh
semanticscholar   +1 more source

The Diverse Roles of Heme Oxygenase-1 in Tumor Progression

Frontiers in Immunology, 2021
Heme oxygenase-1 (HO-1) is an inducible intracellular enzyme that is expressed in response to a variety of stimuli to degrade heme, which generates the biologically active catabolites carbon monoxide (CO), biliverdin and ferrous iron (Fe2+).
K. N. Luu Hoang, Joanne E. Anstee, J. N. Arnold   +2 more
semanticscholar   +1 more source

Alternative 5' untranslated regions are involved in expression regulation of human heme oxygenase-1. [PDF]

PLoS ONE, 2013
The single nucleotide polymorphism rs2071746 and a (GT)n microsatellite within the human gene encoding heme oxygenase-1 (HMOX1) are associated with incidence or outcome in a variety of diseases.
Marcel Kramer, Christoph Sponholz, Monique Slaba, Bianka Wissuwa, Ralf A Claus, Uwe Menzel, Klaus Huse, Matthias Platzer, Michael Bauer   +8 more
doaj   +1 more source

Targeting the Heme-Heme Oxygenase System to Prevent Severe Complications Following COVID-19 Infections

Antioxidants, 2020
SARS-CoV-2 is causing a pandemic resulting in high morbidity and mortality. COVID-19 patients suffering from acute respiratory distress syndrome (ARDS) are often critically ill and show lung injury and hemolysis.
F. Wagener, P. Pickkers, S. Peterson, S. Immenschuh, N. Abraham   +4 more
semanticscholar   +1 more source

Endoplasmic reticulum anchored heme-oxygenase 1 faces the cytosol

Haematologica, 2012
Heme-oxygenase 1 is an endoplasmic reticulum-anchored enzyme that breaks down heme into iron, carbon monoxide and biliverdin. Heme is a hydrophobic co-factor in many proteins, including hemoglobin.
Yehonatan Gottlieb, Marianna Truman, Lyora A. Cohen, Yael Leichtmann-Bardoogo, Esther G. Meyron-Holtz   +4 more
doaj   +1 more source