Results 81 to 90 of about 120,483,411 (287)

Heme oxygenase-1-derived carbon monoxide stimulates adenosine triphosphate generation in human hepatocyte

, 2005
Heme oxygenases cleave the pro-oxidant heme molecule into carbon monoxide, ferrous iron, and biliverdin, which is subsequently converted to bilirubin.
Schlitt, Hans J., Tsui, Tung-Yu, Fan, ST, Siu, Yeung-Tung, Siu, YT, Fan, Sheung-Tat, Schlitt, HJ, Tsui, TY   +7 more
core   +1 more source

Direct Observation of a Hydrogen‐Bonding Assisted Quasi‐Reversible Superoxo/Peroxo Interconversion in a Heme Model

Chemistry – A European Journal, EarlyView.
First direct observation of a quasi‐reversible superoxo (FeIII─O2˙ˉ)/peroxo (FeIII─O22ˉ) redox couple in a heme model complex, featuring a biologically relevant low‐spin ferric end‐on peroxo species stabilized by second‐sphere hydrogen bonding. These findings highlight the key role of second‐sphere interactions in modulating O2 activation pathways ...
Adelais Trapali, Régis Guillot, Christian Herrero, Sylvain Bertaina, Athanassios Coutsolelos, Maylis Orio, Zakaria Halime   +6 more
wiley   +1 more source

Research Progress in Understanding the Relationship Between Heme Oxygenase-1 and Intracerebral Hemorrhage

Frontiers in Neurology, 2018
Intracerebral hemorrhage (ICH) is a fatal acute cerebrovascular disease, with a high morbidity and mortality. Following ICH, erythrocytes release heme and several of its metabolites, thereby contributing to brain edema and secondary brain damage.
Qian-Qian Li, Lan-Jun Li, Xin-Yu Wang, Yu-Ying Sun, Jun Wu   +4 more
doaj   +1 more source

Heme Oxygenase-1 in Kidney Health and Disease [PDF]

Antioxidants & Redox Signaling, 2016
Significance: Acute kidney injury (AKI) and chronic kidney disease (CKD) represent a considerable burden in healthcare. The heme oxygenase (HO) system plays an important role in regulating oxidative stress and is protective in a variety of human and animal models of ...
Jeremie M, Lever, Ravindra, Boddu, James F, George, Anupam, Agarwal   +3 more
openaire   +2 more sources

Transforming Growth Factor‐β (TGF‐β)–Dependent Iron Homeostasis and Altered TGF‐β Responsiveness in FLVCR1‐Deficient CD4 T Cells

Barrier Immunity, EarlyView.
Negative feedback resulting from continuous TGFβRI expression in FLVCR1‐deficient CD4 T cells. Unlike in normal CD4 T cells, TGF‐βRI is not degraded upon activation in FLVCR1‐deficient CD4 T cells. Sustained receptor expression results in increased TGF‐β, leading to dysregulated iron homeostasis, impaired cell proliferation, and enhanced cell death ...
Amber L. Siglin, Zelong Han, Afia Nkansah, Cheong‐Hee Chang   +3 more
wiley   +1 more source

Mechanism of induction of heme oxygenase by metalloporphyrins in primary chick embryo liver cells: evidence against a stress-mediated response

, 2008
Heme oxygenase catalyzes the first and rate-controlling step in heme catabolism. One of the two forms of heme oxygenase (heme oxygenase-1) has been shown to be increased by heme, metals, and in some systems, by certain environmental stresses. However, it
Pepe, Joyce A., Lambrecht, Richard W., Cable, Edward Earl, Bonkovsky, Herbert L., Gildemeister, Otto S.   +4 more
core   +1 more source

Immune Regulation of Heme Oxygenase-1 in Allergic Airway Inflammation

, 2022
Heme oxygenase-1 (HO-1) is not only a rate-limiting enzyme in heme metabolism but is also regarded as a protective protein with an immunoregulation role in asthmatic airway inflammation. HO-1 exerts an anti-inflammation role in different stages of airway
Zhenwei Xia, Wenwei Zhong
core   +1 more source

Heme Oxygenase Protects against Placental Vascular Inflammation and Abortion by the Alarmin Heme in Mice. [PDF]

, 2020
Both infectious as non-infectious inflammation can cause placental dysfunction and pregnancy complications. During the first trimester of human gestation, when palatogenesis takes place, intrauterine hematoma and hemorrhage are common phenomena, causing ...
Christiaan M. Suttorp, Suttorp, Christiaan M, van Rheden, Rene E. M., Suttorp, Christiaan M., Kuijpers-Jagtman, Anne Marie; id_orcid, Helmich, M.P.A.C., van Dijk, Natasja W. M., René E. M. van Rheden, Helmich, Maria P. A. C., Wagener, F.A.D.T.G., Rheden, R.E.M. van, Dijk, N.W.M. van, Wagener, Frank A D T G, Anne Marie Kuijpers-Jagtman, Frank A. D. T. G. Wagener, Wagener, Frank A. D. T. G., Helmich, Maria P A C, Kuijpers-Jagtman, Anne Marie, Maria P. A. C. Helmich, van Rheden, René E M, van Dijk, Natasja W M, Suttorp, C.M., Kuijpers-Jagtman, A.M., Natasja W. M. van Dijk   +23 more
core   +2 more sources

Dapagliflozin alleviates high‐fat‐induced obesity cardiomyopathy by inhibiting ferroptosis

ESC Heart Failure, Volume 12, Issue 2, Page 1358-1373, April 2025.
Abstract Aim: Dapagliflozin (Dapa) is a novel hypoglycaemic agent with multiple cardiovascular protective effects, and it is widely used in treatment of heart failure patients, but whether it can improve obese phenotype of heart failure and its mechanism is still unclear.
Di Chen, Jiahao Shi, Yue Wu, Lizhu Miao, Zilin Wang, Yixuan Wang, Siwei Xu, Yu Lou   +7 more
wiley   +1 more source

Heme oxygenase substrates acutely lower blood pressure in hypertensive rats

, 1996
Heme oxygenase catalyzes the metabolism of heme to biliverdine, free iron, and carbon monoxide. The current study was designed to determine if treatment with the heme oxygenase substrates heme-L-arginate or heme-L-lysinate, to stimulate formation of ...
M. Lavesa, M. J. Scholer, R. A. Johnson, K. DeSeyn, A. Nasjletti   +4 more
core   +1 more source